Hormone Replacement Therapy: In most European countries, the actual Guideline on the Evaluation of New Medicinal Products in the Treatment of Primary Osteoporosis is incomplete in that, unlike the previous Note for Guidance on Postmenopausal Osteoporosis in Women (EMEA 2001 Guidance), it fails to address the prevention of osteoporosis indication.
GnRH-agonists as analogues of the natural GnRH have gained great importance in gynaecological endocrinology and have proven to be particular useful in clinic and practice being applied to treat a large range of clinical conditions. However, the clinical use is negatively influenced by GnRH-agonist induced side effects due to hypoestrogenism, which is the main type of action to be used for treatment and prevention.
To report rates of amenorrhea and treatment failure after global endometrial ablation and to estimate the association between patient factors and these outcomes by developing and validating prediction models.
Of the 600,000 hysterectomies performed yearly in the U.S., approximately 300,000 are accompanied by prophylactic bilateral oophorectomy, traditionally suggested as the best strategy to decrease the rate of ovarian cancer.
Chronic pelvic pain affects a large number of women, and is not often optimally treated within a single specialty. It is responsible for approximately 40% of laparoscopies and 10-15% of hysterectomies in this country. In one survey of 5300 women, more than 16% noted chronic pelvic pain.
Myomectomy is becoming a much more frequently performed procedure certainly it is one that is sought out much more frequently by our patients. Probably the most intimidating form of fibroids is that which occurs in the broad ligament, and particularly one which occurs in the cervical region.
Recently a letter was sent to the Women's Health Forum by a patient who had undergone numerous surgeries in an effort to alleviate her pain due to surgical adhesions. Additionally, I recently had a patient whose case demonstrates a rather typical story for post-surgical adhesions, and her management. These two patient cases I hope you will find informative and "food for thought".
The female reproductive function depends on the healthy ovaries (primary reproductive organ) and genital tract organs. Infertility is one of the main gynecological problems which affect between 10-15% of females in the reproductive age.
Steroid hormones have a typical chemical structure. Their mechanism of action is through binding to a specific receptor which in the nucleus of the cell will induce effects at the genomic level.
Both types of surgery are complimentary. Each has specific advantages and indications. It is an advantage to have and to be able to use both.