Register for Factor V-Leiden and prothrombin G20210A gene mutations heighten miscarriage risk
ThrombosisJanuary 30, 2003
2003 JAN 30 - (NewsRx.com & NewsRx.net) -- According to recent research from Bahrain, "Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis."
R.R. Finan and colleagues, Arabian Gulf University, College of Medicine and Medical Science, wrote: "Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies disputed such a link. The aim of this study was to determine the prevalence of prothrombin G20210A and factor V G1691 A (R506Q, FV-Leiden) mutations in women with recurrent idiopathic abortions and to recommend management for high-risk mutation carriers."
"One hundred ten women with two or more consecutive unexplained first-trimester miscarriages (mean age ± SD, 32.3 ± 5.3) were compared to 67 parous women with uncomplicated pregnancies (mean age ± SD, 33.9 ± 7.3) (p=0.134) from the same ethnic background. The presence or absence of the prothrombin G20210A and FV-Leiden mutations was assessed by PCR and RFLP analysis, using HindIII and MnII digestion, respectively. In women with primary habitual abortion, 45 (40.91%) carried the FV-Leiden mutation, of whom 7 were in the homozygote and 38 were in the heterozygote states, and 15 (13.64%) carried the prothrombin G20210A mutation all as heterozygotes, compared to 16.42% and 2.99% carrier rates among controls, respectively, all of whom were heterozygote carriers. Of the other risk factors analyzed, smoking (OR 1.76; 95% CI = 0.79-3.94) was more prevalent in habitual aborters compared to controls," the authors reported.
The researchers concluded: "Both FV-Leiden and factor II G20210A mutations are major inherited risk factor associated with primary recurrent miscarriages. Women with a family or personal history of thrombosis should be screened before or early in the pregnancy for FV-Leiden and factor II G20210A mutations."
Finan and coauthors published their study in the American Journal of Hematology (Prevalence of factor V G1691A (Factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population. Am J Hematol, 2002;71(4):300-305).
For additional information, contact W.Y. Almawi, Arabian Gulf University, College of Medicine and Medical Science, Department of Biochemistry Medicine, P.O. Box 22979, Manama, Bahrain.
To subscribe to the American Journal of Hematology, contact the publisher: Wiley-Liss, Division John Wiley & Sons Inc., 605 Third Avenue, New York, NY 10158-0012, USA.
The information in this article comes under the major subject areas of Hematology, Mutagenesis, Obstetrics, Thrombosis, and Women's Health. This article was prepared by Women's Health Weekly editors from staff and other reports.
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