Register for Risk factors identified for different histological types of ovarian cancer
Ovarian CancerAugust 10, 2004
2004 AUG 10 - (NewsRx.com & NewsRx.net) -- Different histological types of ovarian cancer may have different etiologic factors, prompting researchers in Italy to try to identify risk factors associated with four histologic categories the disease.
F. Parazzini and colleagues analyzed data "separated by histological subtypes collected in the framework of a large case-control study on ovarian cancer conducted in Italy.
"The cases were women below the age of 75 years, admitted to a network of hospitals in Milan. Cases were grouped into four categories by histological type: mucinous tumor (n=52), serous tumor (n=680), endometrioid tumor (n=41), and other histologies including clear-cell and undifferentiated epithelial tumors (n=50)," the researchers said.
"Controls were 2,758 patients admitted to the same network of hospitals for a wide spectrum of acute, nongynecological, non-hormone-related, non-neoplastic conditions."
According to the researchers' analysis, parous women tended to have lower risk of serous, endometrioid, and other histologies of ovarian cancer compared with women who had not had children. But "the odds ratios (OR) were above unity for mucinous ovarian cancer," Parazzini and colleagues noted.
They found that "[o]ral contraceptive use was associated with OR lower than unity for serous (OR=0.7) and endometrioid (OR=0.8) ovarian cancers but not for mucinous (OR=1.4) and other histologies (OR=1.6)."
"Finally," they said, "our results on dietary fat intake did not show substantial differences in all histological types of ovarian cancer."
Parazzini and coauthors published their study in the International Journal of Gynecological Cancer (Risk factors for different histological types of ovarian cancer. Int J Gynecol Cancer, 2004;14(3):431-436).
Additional information can be obtained by contacting F. Parazzini, Ist Ric Farmacol Mario Negri, Via Eritrea 62, I-20157 Milan, Italy.
The publisher of the International Journal of Gynecological Cancer can be contacted at: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148 USA.
The information in this article comes under the major subject areas of Ovarian Cancer, Risk Factors, Histology, Gynecology, Oncology, and Women's Health. This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2004, Cancer Weekly via NewsRx.com & NewsRx.net.
©Copyright 2004, Cancer Weekly via NewsRx.com & NewsRx.net
