Register for Psoralea corylifolia L. and its derivatives stimulate new bone cell growth
OsteoporosisFebruary 5, 2004
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Psoralea corylifolia L. and its derivatives stimulate new bone cell growth.
According to published research from India, "a cell differentiation bioassay measuring alkaline phosphatase activity was developed using osteoblast-like UMR 106 cell line as a model. The effect of fractions and compounds of Psoralea corylifolia L. extract on osteoblastic differentiation was investigated."
"The fractions or compounds were cocultured with cells for 48 hours (h); the cellular alkaline phosphatase (ALP) activity was then measured. The crude ethanol extract of Psoralea corylifolia L. increased ALP activity by 39.5% at a concentration of 0.1 mg/ml, and the activity was concentrated in the ethyl acetate fraction, which produced a maximum ALP activity increase of 38.2%," reported Z. Xiong and colleagues, Shenyang Pharmaceutical University, School of Pharmacy.
"A significant activity was observed for a flavonoid, corylin, providing 30.0% increment in ALP. These effects suggest that Psoralea corylifolia L. extract, its ethyl acetate fraction and corylin would stimulate bone formation," scientists said.
Xiong and colleagues published their findings in Pharmazie (Osteoblastic differentiation bloassay and its application to investigating the activity of fractions and compounds from Psoralea corylifolia L. Pharmazie, 2003;58(12):925-928).
Additional information can be obtained by contacting F. Li, Shenyang Pharmaceutical University, School Pharmacy, POB 44, 103 Wenhua Rd., New Delhi 110016, India.
The publisher of the journal Pharmazie can be contacted at: Govi-Verlag GmbH, Pharmazeutischer Verlag Ginnheimer Strasse 26, D-65760 Eschborn, Germany.
The information in this article comes under the major subject areas of Osteoporosis, Pharmacology, Complementary and Alternative Medicine, Phytotherapy, and Orthopedics. This article was prepared by Women's Health Weekly editors from staff and other reports. Copyright 2004, Women's Health Weekly via NewsRx.com & NewsRx.net.
©Copyright 2004, Women's Health Weekly via NewsRx.com & NewsRx.net
