Register for CD4+ T cells mediate syngeneic graft-versus-host disease-associated colitis
Graft versus Host Disease,March 3, 2004
CD4+ T cells mediate murine syngeneic graft-versus-host disease-associated colitis.
According to a study from the United States, "Syngeneic graft-vs-host disease (SGVHD) develops following lethal irradiation, reconstitution with syngeneic bone marrow, and treatment with a 21-day course of the immunosuppressive agent cyclosporin A (CsA). Following cessation of CsA, this inducible disease is characterized by weight loss, diarrhea, and development of inflammation in the colon and liver. Although nonspecific effector cells and Th1 cytokines have been shown to participate in disease induction, the role of T cells has not been fully elucidated."
"Initial studies demonstrated significant increases in CD4+ T cells, but not other T cell populations in the colons of diseased animals relative to transplant control animals," said J. Scott Bryson and colleagues at the University of Kentucky. "To demonstrate a functional linkage between increases in colonic CD4+ T cells and disease induction, in vivo T cell depletion studies were performed. Beginning on the day of bone marrow transplantation, groups of control and CsA-treated animals were treated with mAb against either CD4 or CD8 for 21 days."
"Treatment with anti-CD4, but not anti-CD8, eliminated clinical symptoms and colon pathology," reported Bryson and his collaborators. "Interestingly, neither anti-CD4 nor anti-CD8 therapy affected the development of liver pathology associated with SGVHD. These findings demonstrated that CD4+ T cells initiate development of the intestinal inflammation associated with murine syngeneic graft-vs-host disease."
Bryson and his coauthors published their study in the Journal of Immunology (CD4+ T cells mediate murine syngeneic graft-versus-host disease-associated colitis. J Immunol, 2004;172(1):679-687).
For more information, contact J. Scott Bryson, Department of Internal Medicine, Markey Cancer Center, Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA. E-mail: jsbrys@uky.edu.
Publisher contact information for the Journal of Immunology is: American Association of Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA.
The information in this article comes under the major subject areas of Graft-Versus-Host Disease, Colitis, Gastroenterology, Hepatology, Immunology and Proteomics. This article was prepared by Health & Medicine Week editors from staff and other reports.
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