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Editorial Advisor - Michael Kleerekoper, M.B., B.S., F.A.C.P., F.A.C.E. - USA

OBGYN.net Editorial Advisor
Osteoporosis

Michael Kleerekoper, M.B., B.S., F.A.C.P., F.A.C.E. - USA

Michael Kleerekoper, M.B., B.S., F.A.C.P., F.A.C.E. - USA
Articles and Interviews on OBGYN.net by Dr. Kleerekoper



Office Address:
Department of Internal Medicine
Wayne State University School of Medicine
Division of Endocrinology
4201 St. Antoine, UHC-4H
Detroit, MI 48201

Telephone: (313) 745-3320
Fax: (313) 993 0903

Personal Data:

Place of Birth: Leeds, England
Date of Birth: August 18, 1944
Citizenship: United States
Married with 4 children

Education:
The University of Sydney, Australia (1967) - B.Sc. (Med) - Honors II
The University of Sydney, Australia (1970) - M.B., B.S.

Training:

Postgraduate:
Resident Medical Officer, The Royal North Shore Hospital, Sydney, Australia (1970)
Postgraduate Research Scholar (National Health and Medical Research Council), Department of Medicine, The University of Sydney, Australia (1971-1974)
Fellow in Endocrinology and Metabolism, Washington University School of Medicine and The Jewish Hospital of St. Louis, Missouri (1974-1976)

Faculty Appointments:
Professor, Department of Internal Medicine, Obstetrics and Gynecology, and Pathology (with tenure), Wayne State University School of Medicine. (1997-present)
Professor of Medicine and Obstetrics & Gynecology (with tenure), Wayne State University School of Medicine (1993-present)
Professor of Medicine (with tenure), Case Western Reserve University School of Medicine (1992-1993)
Clinical Associate Professor I, Internal Medicine, Medical School, The University of Michigan, Ann Arbor, Michigan (1983-1993)
Clinical Assistant Professor, Department of Medicine, The University of Michigan, Ann Arbor, MI (1977-1983)

Professional Appointments:
1994- 1996 Associate Chairman, Department of Internal Medicine, Wayne State University, Detroit, MI
1994- 1996 Deputy Specialist-in-Chief, Internal Medicine, Detroit Medical Center, Detroit, MI
1993- Director, Bone and Mineral Metabolism and Gerontology Research, Department of Internal Medicine, Division of Endocrinology and Metabolism, Wayne State University
1985-1993 Division Head, Bone and Mineral Division, Henry Ford Hospital, Detroit, MI
1976-1993 Deputy Director, Bone and Mineral Research Lab, Henry Ford Hospital, Detroit, MI
1990-1993 Director, Center for Osteoporosis Research (Henry Ford Hospital, Southfield, MI
1987-1989 Director of Research, General Internal Medicine
1976-1985 Staff Physician, Bone and Mineral Division, Henry Ford Hospital, Detroit, MI
1979-1982 Director, Clinical Research Unit, Henry Ford Hospital, Detroit, MI

Major Professional Societies:
American Association of Clinical Chemistry1,2
American Association for Clinical Endocrinology1
American Federation for Clinical Research
American Medical Association
American Society for Bone & Mineral Research1,2
Central Society for Clinical Research
International Bone and Mineral Society2
Michigan State Medical Society1
New York Academy of Science
The Endocrine Society2
The Society for Clinical Trials
The American Geriatrics Society
Wayne County Medical Society1

1 Committee member
2 Editorial board, Society Journal

Honors & Awards:
Fellow, American College of Physicians (1980)
Member, Central Society for Clinical Research (1990)
Fellow, American College of Endocrinology (1995)
Member (by election), American Clinical and Climatologic Association (1997)

Service:

1. Patient Care
1976 - 1993 Senior Staff Physician, Henry Ford Medical Group and Henry Ford Hospital
1993 - Physician, Division of Endocrinology and Metabolism, Detroit Medical Center
1994 - 1996 Deputy Physician-in-Chief, Detroit Medical Center

2. Professional Consultation
a. Public Presentations:
1987 Presentation to NIH consensus development conference on osteoporosis
1994 Presentation to NIH consensus development conference on optimal calcium intake
1987, 1989, 1991 Presentation to FDA metabolic diseases advisory panel
1997, Presentation to National Academy of medicine conference on stress fractures in the military

b. Testimony before public bodies
Florida Board of Medicine, July 1996 re bone mass measurement

c. Consulting to public agencies, foundations, professional associations
Chairman, Clinical Skeletal Focus Group, NIDR (1997)
Consultant, WHO-ILAR conference on Minimal Standards for Osteoporosis, Santiago, Chile (1996)
Ad Hoc Reviewer - NIH (1984-1996)
Ad Hoc NIH Study Section - Small Grants in Aging (1985)
Ad Hoc Reviewer - VA (1987,1989)
Medical Research Council Canada (1987)
Medical Research Council New Zealand (1992)
Ad Hoc Reviewer, Department of Defense Osteoporosis Research Grants (Panel Chair) (1997)

d. Consulting to private enterprises
Ad Hoc Consultant to Alza, Merck, Organon, Rhone Poulenc Rorer, Sanofi, Wyeth Ayerst pharmaceutical companies (1989-)
Ad Hoc Consultant to Hologic, CompuMed, Metra Biosystems, Hybritech, Bioquant, Osteodyne Technical Companies (1989-)
Scientific Advisory Board, CompuMed, Manhattan Beach, CA (1992-)
Chairman, Clinical Advisory Committee, Metra Biosystems, Mountain View, CA (1995-)
Scientific Advisory Board, Bone Measurement Institute, Merck & Co., West Point, PA (1995-)
Scientific Advisory Board, Merck-Medco (1996- 1998)
Scientific Advisory Board, Pacific Biometrics (1996-)
Chairman, Scientific Advisory Board, Norland Medical Systems (1997-)

3. Journal/Editorial Activity

a. Reviewer for Medical Journals
American Journal of Medicine
Annals of Internal Medicine
Journal of Clinical Endocrinology Metabolism
Mineral and Electrolyte Metabolism
Radiology
Bone and Mineral
Bone
American Journal of Physiology
American Journal of Medical Sciences
Endocrine Reviews
Journal of American Medical Association
New England Journal of Medicine
Journal of Clinical Investigation
Journal of Dental Research
Calcified Tissue International
Journal of Bone and Mineral Research
Journal of Clinical Densitometry

b. Editorial board memberships
Calcified Tissue International (1988-1993)
Bone (1989-)
Journal of Bone & Mineral Research (1990-1996)
Osteoporosis International (1990-)
Clinical Chemistry (1994-)
Journal of Clinical Endocrinology and Metabolism (1996-)
Osteoporosis: Index & Review (1996-)

4. Other professionally related service
Member, Scientific Review Committee, Michigan Chapter, National Kidney Foundation (1983)
American College of Physicians: Michigan Regional Chapter: Annual Meeting Program Committee (1982-1987)
USPHS Panel on Non-Dental Toxicity of Fluoride (1983)
Member, Steering Committee for the International Symposium on Clinical Disorders of Bone & Mineral Metabolism (May, 1983)
Chairman, International Symposium on Clinical Disorders of Bone and Mineral Metabolism (May, 1988 and May, 1993)
Detroit Medical Club, Secretary (1995)
President-elect (1996)
President (1997)

5. National and international boards and committees

a. Positions held in professional associations
Clinical Chemistry: Educational Committee (Endocrine Subcommittee 1987-1988), Arnold O Beckman Conference Committee (1996-)
American Society for Bone & Mineral Research: Education Committee (1984-); Program Committee (1989 -), nominating committee (1996)
National Osteoporosis Foundation: Member, Scientific Advisory Board (1991-)
Member, Board of Trustees (1996-)
American Association of Clinical Endocrinologists: Clinical Practice, Standards, Guidelines and Therapeutics Committee (1996 -)
Michigan Consortium For Osteoporosis (Founder and Member Steering Committee)

b. Memberships/offices held in public agencies related to discipline
Henry Ford Hospital:
Main Campus Advisory Board of Trustees (1984-1992)
Medical Board: Delegate (1978-1982),
Chairman-elect (1982-1984)
Chairman (1984)
Graduate Medical Education Committee (1982-1992)
Continuing Medical Education Committee (1989-1990)
Bone & Joint Specialty Center Executive Committee (1987-1993)
Editorial Board, Henry Ford Hospital Medical Journal (1982-1992)
Advisory Committee on Physician Compensation & Benefits (1983-1986)

Case Western Reserve University:
Committee on Appointments, Promotions and Tenure, Henry Ford Hospital Campus, Chairman (1992-1993)
Committee on Appointments, Promotions and Tenure (1992-1993)

Wayne State University
Institute of Gerontology, Advisory Board (1994-)
Department of Medicine, Research Committee, (1994-)
Dean’s GME Committee (1995-1996)

Harper Hospital
QE/CRM Committee (1994-1997)

Detroit VAMC
Dean’s Committee (1994-1996)

DMC Care
PSO Operating Board (1995-)

6. State and local boards and committees:
Michigan State Medical Society Committee on Aging (1995-)
Wayne County Medical Society
Education Committee (1983-94), Chairman 1993-1999
Ethics Committee (1993-1996)
Medical-Legal Committee (1992-1997)
WCMS Executive Council (1998-1999)
Membership Committee (1995-1996)

Teaching

1. Years at Wayne State: Four

2. Years at other colleges/universities:
University of Michigan (1983-1993)

3. Courses taught at Wayne State in last five years:
a. Undergraduate: None.
b. Graduate: None.
c. Graduate Professional:
03/27/91 Current Concepts in Post-Menopausal Hormone Replacement Therapy The Dearborn Inn, Dearborn, MI
04/08/92 Current Concepts in Post-Menopausal Hormone Replacement Therapy, Eberhard Conference Center, Grand Rapids, MI
10/21/92 Current Concepts in Prevention and Management of Post-Menopausal Osteoporosis, The Dearborn Inn, Dearborn, MI
11/04/92 Endocrinology Review Course, The Fairlane Club, Dearborn, MI
11/06/94 Endocrinology Review Course, The Fairlane Club, Dearborn, MI

d. Medical Students: 2nd Year Pathophysiology, 1994 -
2nd Year Physical Diagnosis, 1994 -
3rd Year Internal Medicine, Endocrinology, 1994 -

e. Residents/Fellows: Elective Rotation for Endocrine Fellows (1992-1993) General Internal Medicine Rounds(1994-) Endocrine Rounds(1995-)
Professor’s Rounds (coordinator)(1994 -)

4. Essays/Theses/Dissertations directed: None.

Course or curriculum development: "Critical thinking in clinical science". A bi-monthly course for Internal Medicine residents, scheduled to begin in September 1995. The course is designed to teach participants how to properly integrate the skills needed for all aspects of patient care with those needed for patient oriented research.

Biomedical Engineering, (BME # 525): Developed a one semester curriculum on Osteoporosis and Fractures in conjunction with Dorothy Nelson, Ph. D.

Publications:

1. Original observations in refereed journals

    1. Kleerekoper M, Horne M, Cornish CJ, Posen S: Human alkaline phosphatase after fat ingestion: An immunological study. Clin Sci 38:339-345, 1970.

    2. Kleerekoper M, Donald RA, Posen S: Corticotrophin in cerebrospinal fluid of patients with Nelson's syndrome. Lancet 1:74-76, 1972.

    3. Kleerekoper M, Ingham JP, McCarthy SW, Posen S: Parathyroid hormone assay in primary hyperparathyroidism: Experiences with a radioimmunoassay based on commercially available reagents. Clin Chem 20:369-375, 1974.

    4. Ingham JP, Kleerekoper M, Steward JH, Posen S: Symptomatic skeletal disease in non-terminal renal failure. Med J Aust 1:873-876, 1974.

    5. Sebel EF, Hull RD, Kleerekoper M. Stokes GS: Responses to glucagon in hypertensive patients with and without pheochromocytoma. Am J Med Sci 267:337-343, 1974.

    6. Kleerekoper M, Basten A. Penny R, Posen S: The syndrome of idiopathic hypoparathyroidism with primary ovarian failure. Report of a case with detailed immunological studies. Arch Int Med 134:944-947, 1974.

    7. Weber WA, Kleerekoper M. Thornell IR, Stokes GS: Effects of sodium depletion on plasma renin activity and on the urinary excretion of cyclic AMP and aldosterone in hypoparathyroid patients. J Clin Endocrinol Metab 40:982-987, 1975.

    8. Kleerekoper M, Ibels LS, Ingham JP, McCarthy SW, Mahoney JF, Stewart JH, Posen S: Hyperparathyroidism after renal transplantation. Br Med J 3:680-692, 1975.

    9. Posen S, Kleerekoper M, Ingham JP, Hirshorn JE: Parathyroid hormone assay in clinical decision making. Br Med J 1:16-19, 1976.

    10. Kleerekoper M, Coffey R, Greco T, Nicholls S, Murphy W, Avioli LV: Hypercalcemic hyperparathyroidism in hypophosphatemic rickets. J Clin Endocrinol Metab 45:86-94, 1977.

    11. Whyte MP, Murphy WA, Kleerekoper M, Teitelbaum SL, Avioli LV: Idiopathic multicentric osteolysis: Report of an affected father and son. Arthritis Rheum 21:367-376, 1978.

    12. Kleerekoper M, Rao DS, Frame B: Hypercalcemia, hyperparathyroidism and hypertension. Cardiovasc Med 1283-1295, 1978.

    13. Block MA, Frame B, Kleerekoper M, Rao DS: Surgical management of persistence or recurrence after subtotal parathyroidectomy for primary hyperparathyroidism. Am J Surg 138:561-566, 1979.

    14. Russell JE, Kleerekoper M, Slatopolsky E, Lewis J, Lee SW, Avioli LV: Dissociation of renal cyclic AMP and phosphate responses to parathyroid hormone in uremia. Calcif Tissue Int 29:147-154, 1979.

    15. Rao DS, Frame B, Miller MJ, Kleerekoper M, Block MA, Parfitt AM: Hyperparathyroidism following head and neck irradiation. Arch Int Med 140:205-207, 1980.

    16. Kleerekoper M, Rao DS, Frame B, LaRocque Rd, Feigelman T, Matkovic V, Avioli LV: Occult Cushing's syndrome presenting with osteoporosis. Henry Ford Hosp Med J 28:132-137, 1980.

    17. Frame B, Jackson GM, Kleerekoper M, Rao DS, DeLorenzo AJD, Garcia M: Acute severe hypercalcemia ala Munchausen. Am J Med 70:316-319, 1981.

    18. Kleerekoper M, Tolia K, Parfitt AM: Nutritional, endocrine and demographic aspects of osteoporosis. Orthop Clin North Am 12:547-558, 1981.

    19. Bernstein JM, Kleerekoper M: Familial hypokalemic periodic paralysis in blacks. Henry Ford Hosp Med J 30:55-58, 1982.

    20. Kleerekoper M: Fads in medicine: In the clinical laboratory. (Editorial) Henry Ford Hosp Med J 30:104, 1982.

    21. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS: Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis: Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72:1369-1409, 1983.

    22. Rao DS, Parfitt AM, Kleerekoper M, Pumo BS, Frame B: Dissociation between the effects of endogenous parathyroid hormone on cAMP generation and on phosphate reabsorption in hypocalcemia due to vitamin D depletion: An acquired disorder resembling pseudohypoparathyroidism type II. J Clin Endocrinol Metab 61:285-290, 1985.

    23. Kleerekoper M, Villanueva AR, Stanciu J, Rao DS, Parfitt AM: The role of three dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif Tissue Int 37:594-597, 1985.

    24. Parfitt AM, Rao DS, Stanciu J, Villanueva AR, Kleerekoper M, Frame B: Irreversible bone loss in osteomalacia: Comparison of radial photon absorptiometry with iliac bone histomorphometry during treatment. J Clin Invest 76:240-2412, 1985.

    25. VanSlyck EJ, Kleerekoper M, Abraham JP, Deegan MJ: Case report: Non-secretory multiple myeloma with osteoporosis. Immunocytologic and bone resorptive studies. Am J Med Sci 29:347-351, 1986.

    26. Maynard JC, Kleerekoper M, Cruz C, Levin NW: Blood pressure response to changes in serum ionized calcium during hemodialysis. Ann Intern Med 104:358-361, 1986.

    27. Jackson JA, Kleerekoper M, Parfitt AM: Symptomatic osteoporosis in a man with hyperprolactinemic hypogonadism. Ann Intern Med 105:543-545, 1986.

    28. Shier CK, Ellis BI, Tennyson G, Kleerekoper M: Nineteen-year radiographic follow-up of untreated Paget's disease of bone. Henry Ford Hosp Med J 34:127-129, 1986.

    29. Parfitt AM, Kleerekoper M, Cruz C: Reduced phosphate reabsorption unrelated to parathyroid hormone after renal transplantation: Implications for the pathogenesis of hyperparathyroidism in chronic renal failure. Mineral Electrolyte Metab 12:356-362, 1986.

    30. Kruger DM, Lee J, Raines A, Lyne ED, Kleerekoper M: Vitamin D metabolism and skeletal disease in pediatric populations. J Clin Immunoassay 9:200-202, 1986.

    31. Rao DS, Parfitt AM, Villanueva AR, Dorman PJ, Kleerekoper M: Hypophosphatemic osteomalacia and adult Fanconi syndrome due to light-chain nephropathy: Another form of oncogenous osteomalacia. Am J Med 82:333-338, 1987.

    32. Shier CK, Ellis BI, Kleerekoper M, Jurisson ML: Disseminated migratory osteoporosis: An unusual pattern of osteoporosis. J Can Assoc Radiol 38(1):56-59, 1987.

    33. McKenna MJ, Kleerekoper M, Ellis BI, Rao Ds, Parfitt AM, Frame B: Atypical insufficiency fractures confuse with Looser zones os osteomalacia. Bone 8:71-78, 1987.

    34. Kruger DM, Lyne ED, Kleerekoper M: Vitamin D deficiency rickets: Three cases. Clin Orthop 224:277-283, 1987.

    35. Kleerekoper M, McKenna MJ: Osteoporosis and the clinical chemist. Am Assoc Clin Chem. In-Service Training Program, 1987.

    36. Riggs BL, Baylink DJ, Kleerekoper M, Lane JM, Melton LJ III, Meunier JP: Incidence of hip fractures in osteoporotic women treated with sodium fluoride. J Bone Min Res 2:123-126, 1987.

    37. Jackson JA, Kleerekoper M, Parfitt AM, Rao DS, Villanueva AR, Frame B: Bone histomorphometry in hypogonadal and eugonadal men with spinal osteoporosis. J Clin Endocrinol Metab 65:53-58, 1987.

    38. Brown GG, Preisman RC, Kleerekoper M: Neurobehavioral symptoms in mild primary hyperparathyroidism: Related to hypercalcemia but not improved by parathyroidectomy. Henry Ford Hosp Med J 35:211-215, 1987.

    39. Kleerekoper M. Mellinger RC: Aspects of endocrinology (editorial). Henry Ford Hosp Med J 35:180, 1987.

    40. Wilson RJ, Rao DS, Ellis BI, Kleerekoper M, Parfitt AM: Mild asymptomatic primary hyperparathyroidism is not a risk factor for vertebral fractures. Ann Int Med 109:959-962, 1988.

    41. Rao DS, Wilson RJ, Kleerekoper M, Parfitt AM: Lack of biochemical progression or continuation of accelerated bone loss in mild asymptomatic primary hyperparathyroidism: Evidence for biphasic disease course. J Clin Endocrinol Metab 67:1294-1298, 1988.

    42. Parfitt AM, Villanueva AR, Stanciu J, Kleerekoper M: The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Clin Res Int 36:498, 1988.

    43. Kleerekoper M, Nelson D: Osteoporosis as a community health problem. Lessons learned from studying hypertension. Henry Ford Hosp Med J 36:113-116, 1988.

    44. Nelson DA, Kleerekoper M, Parfitt AM: Bone mass, skin color and body size among black and white women. Bone and Mineral 4:257-260, 1988.

    45. Lee JJK, Lyne ED, Kleerekoper M, Logan MS, Belfi RA: Disorders of bone metabolism in severely handicapped children and young adults. Clin Orthopaedics 245:297-302, 1989.

    46. Feldkamp LA, Goldstein SA, Parfitt AM, Jesion G, Kleerekoper M: The direct examination of the three dimensional bone architecture in vitro by computed tomography. J Bone Min Res 4:3-11, 1989.

    47. Kleerekoper M: Experimental therapeutic strategies to increase bone mass. Postgraduate Medicine Spec No:26-28, 1989.

    48. Kleerekoper M, Peterson E, Nelson D, Tilley B, Phillips E, Schork AM, Kuder J: Identification of women at risk for developing postmenopausal osteoporosis with vertebral compression fractures: Role of history and single photon absorptiometry. Bone and Mineral 7:171-186, 1989.

    49. Nelson D, Peterson E, Tilley B, O'Fallon W, Chao E, Riggs BL, Kleerekoper M: Measurement of vertebral area on spine x-rays in osteoporosis: Reliability of Digitizing techniques. Bone Min Res 5:707-716, 1990.

    50. Jackson JA, Kleerekoper M: Osteoporosis in men: Diagnosis, pathophysiology and prevention. Medicine, 69:137-149, 1990.

    51. Wilson PS, Kleerekoper M, Bone H, Parfitt AM: Measurement of urinary total hydroxyproline by HPLC: Comparison of spot and timed urine collections. Clin Chem 36:388-389, 1990.

    52. Tilley BC, Kleerekoper M, Peterson EL, Phillips E, Nelson DA, Scork MA: Designing clinical trials of treatment for osteoporosis: Recruitment and follow-up. Calcif Tissue Int 47:327-331, 1990.

    53. Kleerekoper M, Balena R: Flourides and osteoporosis. Annual Review Nutrition 11:309- 324, 1991.

    54. Foldes J, Balena R, HO A, Parfitt AM, Kleerekoper M: Hypophosphatemic rickets with hypercalciuria following long-term treatment with Aluminum-containing antacid. Bone 12:67-71, 1991.

    55. Kleerekoper M: For steroid-induced osteoporosis therapy, assess bone mass, chemistry. Musculoskeletal Med 8:10-11, 1991.

    56. Kleerekoper M, Brienza R, Schultz L, Johnson C: Oral contraceptive use may protect against low bone mass. Arch Int Med 151:1971-1976, 1991.

    57. Mendlovic D, Kleerekoper M: A meta-analysis of estrogen replacement and breast cancer. JAMA 266:1358, 1991.

    58. Parfitt AM, Rao DS, Kleerekoper M: Asymptomatic primary hyperparathyroidism discovered by multichannel biochemical screening: Clinical course and considerations bearing on the need for surgical intervention. J Bone Miner Res, 6(Suppl 2):S97-S101, 1991.

    59. Kleerekoper M, Peterson E, Phillips E, Nelson D, Schork MA, Parfitt AM, Tilley B: A randomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis. Osteopor Int 1:155-161, 1991.

    60. Foldes J, Parfitt AM, Shih M-S, Rao DS, Kleerekoper M: Structural and geometric changes in iliac bone: Relationship to normal aging and osteoporosis. J Bone Miner Res 6:759-766, 1991.

    61. Kleerekoper M, Nelson DA, Peterson EL, Tilley BC: Outcome variables in osteoporosis trials. Bone 13:529-34, 1992.

    62. Krakauer JC, Kleerekoper M: Borderline low serum TSH is correlated with increased fasting urinary hydroxyproline excretion. Arch Int Med 152:360-364, 1992.

    63. Kleerekoper M, Nelson DA: Vertebral fracture or vertebral deformity? Editorial Calcif Tissue Int 50:5-6, 1992.

    64. Edelson GW, Kleerekoper M, Talpos G, Zarbo R, Saeed-uz-Zafar M: Mucin-Producing parathyroid carcinoma. Bone 13:7-10, 1992.

    65. Nelson D, Feingold M, Mascha E, Kleerekoper M: Comparison of single photon and dual energy x-ray absorptiometry of the radius. Bone and Min 18(1):77-83, 1992.

    66. Kleerekoper M, Balena R: Flourides and Osteoporosis. Southern Medical Journal 85(8):2S34-42, 1992.

    67. Kleerekoper, M: "Please Pass the Roach Poison Again." Editorial JAMA 268:781-782, 1992.

    68. Foldes J, Wilson P, Saeed SM, Buck K, Parfitt, AM, Kleerekoper, M: Parathyroid stimulation after bleeding in man. ACTA Endocrinologica 127:138-141, 1992.

    69. Bone HG, Kleerekoper M: Pagets Disease of Bone. J Clin Endo Metab 75(5):1179-1182, 1992.

    70. Nelson DA, Kleerekoper M, Peterson E, Parfitt AM: Skin color and body size are not risk factors for osteoporosis. Osteopor Int 3:18-23, 1993.

    71. Jackson JA, Mendlovic D, Kleerekoper M: Endocrine Grand Rounds: A 51 year old man with accelerated hypertension, hypercalcemia and right adrenal and peritracheal masses. The Endocrinol 3:5-13, 1993.

    72. Kleerekoper M, Mendlovic D: Sodium fluoride therapy of osteoporosis. Endocrine Reviews 14(3):312-323, 1993.

    72a. Kleerekoper M, Medlovic D: Sodium fluoride therapy of postmenopausal osteoporosis: Update 1995, Endocrine Reviews Monographs 4. "Hormonal Regulation of Bone Mineral Metabolism" 328-341, 1995.

    73. Nelson D, Kleerekoper M, Pawluszka A, Kirk C, Siegel D, Jacobsen G, Peterson E. Recruitment of older black and white women for a longitudinal study of skeletal health. J Women's Health 2:359-366, 1993.

    74. Kleerekoper M, Nelson DA, Peterson EL, Flynn MJ, Pawluszka AS, Jacobsen G, Wilson P. Reference data for bone mass, calciotropic hormones, and biochemical markers of bone remodeling in older (55-75), postmenopausal white and black women. J Bone Miner Res 9:1267-1276, 1994.

    75. Kleerekoper M, Bilezikian. A cure in search of a disease. Parathyroidectomy for primary hyperparathyroidism. Editorial, Am J Med 96 (2):99-100, 1994.

    76. Kleerekoper M, Nelson DA, Flynn MJ, Pawluszka AS, Jacobsen G, Peterson EL. Comparison of radiographic absorptiometry (RA) with dual energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) in normal older white and black women. J Bone Miner Res 9(11):1745, 1994.

    77. Kleerekoper M, Nelson DA, Peterson EL, Wilson PS, Jacobsen G, Longcope C. Body composition and gonadal steroids in older white and black women. J Clin Endocrinol Metab 79(3):775-779, 1994.

    78. Nelson DA, Kleerekoper M, Peterson EL: Reversal of vertebral deformities in osteoporosis: measurement error or "rebound"? J Bone and Miner Res 9:977-982, 1994

    79. Demers LM, Kleerekoper M: Recent advances in biochemical markers of bone turnover. Editorial Clinical Chemistry 40:1994-5, 1994.

    80. Edelson GW, Kleerekoper M: Hypercalcemic Crisis. Med Clin of North America (79(1):79-92, 1995.

    81. Kleerekoper M: Extensive personal experience: The clinical evaluation of the osteoporotic patient. J Clin Endocrinol Metab 80:757-763, 1995.

    82. Kleerekoper M. Osteoporosis for the Primary Care Physician: Time to Bone Up. Editorial Annals of Internal Medicine 123:466-7, 1995

    83. Kleerekoper M, Schiebinger RJ: Skeletal recovery after treatment of Cushing's: Still room for improvement. Editorial J Clin Endocrinol Metab 80:2856-8, 1995.

    84. Kleerekoper M, Sullivan JM: Osteoporosis as a model of the long-term clinical consequences of the menopause. Editorial Progress in Cardiovascular Disease 38:181-8, 1995. [Guest co-editor, with Dr. Sullivan, of this issue of this journal.]

    85. Hodgson SF, Johnston CC, Avioli LV, Heath III HH, Khosla S, Kleerekoper M, Lindsay R, Lufkin EG, Riggs BL, Watts NB: AACE Clinical Practice Guidelines for the Prevention and Treatment of Postmenopausal Osteoporosis. Endocrine Practice 2:155-171, 1996.

    86. Kleerekoper M. Sodium Fluoride: The verdict is in but the controversy lingers. Editorial J Bone and Mineral Res 11:565-567, 1996.

    87. Kleerekoper M: Fluoride and the skeleton. Critical Reviews in Clin Lab Sci (33(2):139-161, 1996

    88. Kleerekoper M: Biochemical markers of bone remodeling. Am J Med Sci 312(6):270-277, 1996.

    89. Lydick E, Zimmerman SI, Yawn B, Love B, Kleerekoper M: Development and validation of a discriminative quality of life questionnaire for osteoporosis (the OPTQoL). J Bone & Miner Res 12(3):456-463, 1997.

    90. Nelson DA, Kleerekoper M: The search for the osteoporosis gene. Editorial J Clin Endocrinol Metab 82(4):989-990, 1997.

    91. Kleerekoper M, Nelson DA: Which bone density measurement? Editorial J Bone & Miner Res 12(5):712-714, 1997.

    92. Kleerekoper M, Schiebinger R, Gutai JU: Steroid therapy for adrenal disorders-getting the dose right. Editorial J Clin Endocrinol Metab 82(12):3923-3925, 1997.

    93. Balena R, Kleerekoper M, Foldes JA, Shih M-S, Rao DS, Schober HC, Parfitt MA: Effects of different regimens of sodium fluoride treatment for osteoporosis on the structure, remodeling and mineralization of bone. Osteopor Int 1998 (in press).

    94. Kleerekoper M, Nelson DA. Bone mineral density testing at the menopause and beyond - An opinion. Menopause Management 7:21-24, 1998.

    95. Kleerekoper M: Detecting osteoporosis; beyond the history and physical examination. Postgraduate Medicine 103(4):45-68, 1998.

    96. Nelson DA, Molloy R, Kleerekoper M: Prevalence of osteoporosis in women referred for bone density testing. J Clin Densit 1(1):5-11, 1998.

    97. Kleerekoper M: The role of fluoride in the prevention of osteoporosis. Osteoporosis 27(2):441-452, 1998.

    98. Edelson G, Kleerekoper M: The use of bone markers in osteoporosis. J Clin Ligand Assay 21:96-101, 1998.

    99. Kleerekoper M: Osteoporosis: A four article symposium. Postgraduate Medicine 104(4):51-52, 1998.

    100. Goddard D, Kleerekoper M: The epidemiology of osteoporosis. Postgraduate Medicine 104(4):54-72, 1998.

    101. Miller PD, Bonnick SL, Johnston CC, Kleerekoper M, Lindsay RL, Sherwood LM, Siris ES: The challenges of peripheral bone density testing which patients need additional central density skeletal measurements? J Clin Densit, 1(3):211-217, 1998.

    102. Kleerekoper M: Biochemical markers of bone remodeling in day to day patient care. Contemporary Ob/Gyn 43(11):35-45, 1998.

    103. Speroff L, Bachmann GA, Kleerekoper M, Mishell DR, Stampfer MJ, Sullivan JM: Postmenopausal hormone therapy: treatment choices for medical conditions. Contemporary Ob/Gyn (suppl), 11, 1998.

    104. Kleerekoper M: Nasal calcitonin and fluorides for osteoporosis treatment and prevention. In: Supplement to Obstetrical & Gynecological Survey: Estrogen Deficiency in Breast Cancer. (suppl) 53(10):S43-S44, 1998.

2. Review Articles

1. Posen S, Cornish CJ, Kleerekoper M: Alkaline phosphatase in the diagnosis of metabolic bone disorders. In: Parfitt AM, Frame B, eds. Proc of International Symposium on Clinical Aspects of Metabolic Bone Disease. Amsterdam: Excerpta Medica 74-79, 1973.

2. Parfitt AM, Mathews M, Rao DS, Kleerekoper M: The regulation of 25-hydroxylation by vitamin D intake in man: A theoretical model. In: Norman AW et al, eds. Vitamin D: Basic research and its clinical application. Berlin: Walter DeGruyter, 496-500, 1979.

3. Kleerekoper M, Cruz C, Bernstein RS, Levin NW, Foreback CC, Parfitt AM: The phosphaturic action of PTH in the steady state in patients with normal and impaired renal function. Phosphate and Minerals in Health and Disease. Adv Exp Med Biol 128:145-154, 1980.

4. Parfitt AM, Rao DS, Kleerekoper M, Walczak N. Levin N, Oliver I, Frame B: Proximal and distal radial bone mineral measurement in primary and secondary hyperparathyroidism: Diagnostic value and response to treatment. In: Mazess RB, ed. Proc. for the Fourth International Conference on Bone Mineral Measurement. NIH Publication, 80-1938:183-190, 1980.

5. Zinn D, Cruz C, Smith D, Potocki M, Parfitt C, Hricak H, Levin NW, Kleerekoper M: Reduction in dialysate calcium concentration lowers skin calcium content in patients on chronic hemodialysis. Trans Am Soc Artif Inten Organs 26:378-382, 1980.

6. Kleerekoper M, Bernstein RS, Rao Ds, Frame B, Levin NW, Parfitt AM: Parathyroid hormone, phosphate and the kidney. Prog Biochem Pharmacol 17:190-198, 1980.

7. Parfitt AM, Rao DS, Kleerekoper M, Walczak N. Levin N, Oliver I, Frame B: Midshaft and distal radius bone mineral in primary and secondary hyperparathyroidism: Diagnostic value and response to treatment. Proceedings of the Fourth International Conference on Bone Measurement, 1980. US Dept. H.H.S. NIH 80-1938, Bethesda, 183-190.

8. Parfitt AM, Mathews C, Rao D, Frame B, Kleerekoper M, Villanueva AR: Impaired osteoblast function in metabolic bone disease. In: Deluca HF, Frost H, Jee W, Johnston C, Parfitt AM, eds. Osteoporosis: Recent Advances in Patho-genesis and Treatment. Baltimore: University Park Press, 321-330, 1981.

9. Kleerekoper M, Frame B, Villanueva AR, Oliver I, Rao DS, Matkovic V, Parfitt AM: Treatment of osteoporosis with sodium fluoride alternating with calcium and vitamin D. In: Deluca HF, Frost H, Jee W, Johnston C, Parfitt AM, eds. Osteoporosis: Recent Advances in Pathogenesis and Treatment. Baltimore: University Park Press 441-448, 1981.

10. Kleerekoper M, Oliver I, Frame B, Rao DS, Villanueva AR, Parfitt AM: Adverse effect of Vitamin D in fluoride treated osteoporosis. Veterinary and Human Toxicology 24:388, 1982.

11. Kleerekoper M, Bernstein RS, Cruz C, Levin NW, Parfitt AM: Parathyroid hormone resistance in renal allograft recipients. In: Massry SG, Letteri JM, Ritz E, eds. Proc 5th International Workshop on Phosphate and Other Minerals Regulations of Phosphate and Mineral Metabolism. Adv Exp Med Biol 151:185-187, 1982.

12. Kleerekoper M, Parfitt AM: Skeletal histology in osteoporosis: Effect of fluoride therapy. Proc in the Int Fluoride Symposium, Utah State University, Logan, Utah, May 1982.

13. Kleerekoper M: The management of primary hyperparathyroidism. Overview. In: Frame B, Potts J Jr, eds. Clinical Disorders of Bone and Mineral Metabolism. Amsterdam: Excerpta Medica, 149-151, 1983.

14. Kleerekoper M, Villanueva AR, Mathews CHE, Rao DS, Pumo B, Parfitt AM: PTH mediated bone loss in primary and secondary hyperparathyroidism. In: Frame B, Potts J Jr, eds. Clinical Disorders of Bone and Mineral Metabolism. Amsterdam: Excerpta Medica, 200-203, 1983.

15. Rao DS, Villanueva A, Mathews M, Pumo B, Frame B, Kleerekoper M. Parfitt AM: Histologic evolution of vitamin D depletion in patients with intestinal malabsorption or dietary deficiency. In: Frame B, Potts J Jr, eds. Clinical Disorders of Bone and Mineral Metabolism. Amsterdam, Excerpta Medica, 224-226, 1983.

16. Parfitt AM, Mathews CHE, Villanueva AR, Rao DS, Rogers M, Kleerekoper M, Frame B: Microstructural and cellular basis of age related bone loss and osteoporosis. In: Frame B, Potts J Jr, eds. Clinical Disorders of Bone and Mineral Metabolism. Amsterdam, Excerpta Medica, 328-332, 1983.

17. Talpos GE, Kleerekoper M, Kambouris A, Morre DR: Management of primary hyperparathyroidism. Report on workshop. Frame B, Potts J Jr, eds. Clinical Disorders of Bone and Mineral Metabolism. Amsterdam, Excerpta Medica, 537-539, 1983.

18. Rao DS, Marel G, Wong K. Zonca M, Kleerekoper M, Frame B, Parfitt AM: Reversible and irreversible skeletal disease in adult coeliac disease. In: Chon DV, Potts JT Jr, Fujita T, eds. Endocrine control of bone and calcium metabolism. Elsevier Science Publishers B.V., 279-280, 1984.

19. Kleerekoper M: Controlled clinical trials in osteoporosis. Proceedings of the workshop on the Coherence Therapy for Osteoporosis, February 10-11, 1984.

20. Kleerekoper M, Parfitt AM, Ellis BI: Measurement of vertebral fracture rates in osteoporosis. In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL, eds. In: Osteoporosis: Proc Copenhagen Int Symposium on Osteoporosis, June 3-8, 1984. Aalborg Stiftsbogtrykkeri, pp 103-109.

21. Parfitt AM, Kleerekoper M: Diagnostic value of bone histomorphometry and comparison of histologic measurements and biochemical indices of bone remodeling. In: Christiansen C, Arnaud CS, Nordin BEC, Parfitt AM, Peck WA, Riggs BL, eds. In: Osteoporosis. Proc Copenhagen Int Symposium on Osteoporosis, June 3-8, 1984. Aalborg Stiftsbogtrykkeri, pp. 111-120.

22. Kleerekoper M, Parfitt AM, Ellis BI: Measurement of vertebral fracture rates in osteoporosis. In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL, eds. Osteoporosis. Proc Copenhagen Int Symposium on Osteoporosis, June 3-8, 1984. Aalborg Stiftsbogtrykkeri, pp. 103-109.

23. Kleerekoper M: Are there different types of osteoporosis and does it matter? In: Posen S, ed. A discussion on the diagnosis and treatment of osteoporosis. Bern, Hans Huber Publishers, 51-55, 1986.

24. Kleerekoper M: The prevention of postmenopausal osteoporosis with estrogen: Treating the menopause as an endocrine deficiency state. ASBMR Workshop, 1986.

25. Kleerekoper M, Feldkamp LA, Goldstein SA: The effect of aging on the skeleton - implications for changes in tolerance. In: Biomechanics and Medical Aspects of Lower Limb Injuries. Society of Automotive Engineers Inc., Warrandale, PA. pp 91-96, 1986.

26. Kleerekoper: Primary hyperparathyroidism. In: Proceedings of the International Symposium on Metabolic Bone Diseases in Osteoporosis, Santiago, Chile, April 17-19, 1986.

27. Kleerekoper M: Selected laboratory procedures in patients with clinical disorders of bone and mineral metabolism. In: Proceeding of the International Symposium on Metabolic Bone Diseases in Osteoporosis, Santiago, Chile, April 17-19, 1986.

28. Kleerekoper M: Clinical disorders of calcium homeostatic - an overview. In: Proceedings of the International Symposium on Metabolic Bone Diseases in Osteoporosis, Santiago, Chile, April 17-19, 1986.

29. Kleerekoper M: Osteoporosis. In: Proceedings of the International Symposium on Metabolic Bone Diseases in Osteoporosis, Santiago, Chile, April 17-19, 1986.

30. Parfitt AM, Rao DS, Kleerekoper M, Villanueva AR: Increased bone age: Mechanisms and consequences. IN: Christiansen C, Johansen C, Riis BJ, eds. Osteoporosis 1987. Osteopress Aps, Copenhagen, pp 301-308.

31. Kleerekoper M, Dickie D, Feldkamp LA, Goldstein SA, Flynn MJ, Parfitt AM: Cancellous bone architecture and bone strength. In: Christiansen C, Johansen C, Riis BJ, eds. Osteoporosis 1987. Osteopress Aps, Copenhagen, pp 294-300.

32. Kleerekoper M: Experimental therapeutic strategies to increase bone mass. Postgraduate Medicine 1989- A special report: Long-term effects of estrogen deprivation. pp 26-28, 1989.

34. Balena R, Flynn MJ, Foldes J, Parfitt AM, Kleerekoper M: Application of Image Analysis in Metabolic Bone Diseases. In: Guardabasso V, Rodbard D, Forti G, eds. Computers in Endocrinology: Recent Advances. pp 159-170, 1990.

35. Parfitt AM, Villanueva AR, Rao D, Kleerekoper M: Remodeling mechanisms that contribute to bone loss and fracture. Proceedings from the Fifth International Congress on Bone Morphometry 1990. Bone Morphometry. Nishimura Co LTD, Japan, pp 346-354.

36. Kleerekoper M: Non-dental tissue effects of fluoride. Advances in Dental Research 8:32-38, 1994.

37. Edelson GW, Kleerekoper M: Hypercalcemic crisis. Med Clin North Am 79(1):79-92, 1995.

38. Edelson GW, Kleerekoper: Bone mass, bone loss, and fractures. Physical Medicine and Rehabilitation Clinics of North America 6:455-464, 1995.

39. Edelson GW, Kleerekoper M: Biochemical Studies in the Evaluation and Management of Osteoporosis - Current Status and Future Prospects. Endocrine Practice 2:13-19, 1996.

40. Kleerekoper M. Fluoride and the skeleton. Critical Reviews in Clinical Laboratory Sciences 33:139-161, 1996.

41. Kleerekoper M. Biochemical markers of bone remodeling. Am J Med Sci 312:270-277, 1996.

3. Books and Chapters

1. Posen S, Cornish CJ, Kleerekoper M; Alkaline phosphatase and metabolic bone disease. In: Avioli LV, Krane SM, eds. Metabolic Bone Disease. New York: Academic Press, 141-181, 1977.

2. Kleerekoper M: Osteomalacia and rickets. In: Tice's Practice of Medicine New York: Harper Row. Chapter 51, 1979.

3. Parfitt AM, Kleerekoper M: The divalent ion homeostatic system. Physiology and metabolism of calcium, phosphorus, magnesium and bone. In: Maxwell M, Kleeman CR, eds. Clinical Disorders of Fluid and Electrolyte Metabolism, 3rd ed. New York: McGraw Hill, pp 269-398, 1980.

4. Parfitt AM, Kleerekoper M: Clinical disorders of calcium, phosphorus and magnesium metabolism. In: Maxwell M, Kleeman Cr, eds. Clinical Disorders of Fluid and Electrolyte Metabolism, 3rd ed. New York: McGraw Hill, pp 947-1151, 1980.

5. Frame B, Kleerekoper M: Rickets and osteomalacia. In: Conn HF, ed. Current Therapy. Philadelphia: W.B. Sanders, 447-451, 1980.

6. Kleerekoper M: Laboratory evaluation in patients with abnormal bone and mineral homeostasis. In: Stein JH, ed. Internal Medicine: A Systematic Approach. Boston: Little, Brown & Co, 1829-1836, 1983.

7. Kleerekoper M: Paget's Disease. In: Spittell JA Jr, ed. Clinical Medicine. Philadelphia, Harper & Row, 1984.

8. Kleerekoper M, Rao DS: Hypercalcemia and hypocalcemia. In: Callaham M, ed. Current Therapy in Emergency Medicine. B.C. Decker, Inc, 729-732, 1986.

9. Clinical Disorders of Bone and Mineral Metabolism. Michael Kleerekoper and Stephen M. Krane editors. Mary Ann Liebert, Inc. New York, publishers. pp 1-649, 1989.

10. Kleerekoper M and Gaasch W: "Hypercalcemia and Hypocalcemia" in Decision Making in Emergency Medicine. J. Callahan, Ed. B.C. Decker Inc. Publisher: Philadelphia, pp 168-169, 1990.

11. Primer on the Metabolic Bone Diseases and Diseases of Mineral Metabolism: MJ Favus, ed., M Kleerekoper, associate ed., American Society for Bone and Mineral Research, Publisher.
First edition 1990.
Second edition 1993. Raven Press, publisher.
Third edition 1996. Raven Press, publisher (in preparation).

12. Kleerekoper M, Avioli LV: Evaluation and treatment of postmenopausal osteoporosis. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. MJ Favus, ed., American Society for Bone and Mineral Research, publisher, pp 151-154, 1990.

13. Kleerekoper M, Avioli LV: Evaluation and treatment of postmenopausal osteoporosis. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 2nd edition. MJ Favus, Ed. Raven Press, publisher, pp.223-229,1993.

14. Kleerekoper M, Avioli LV: Evaluation and treatment of postmenopausal osteoporosis. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 3rd edition. MJ Favus MJ, Ed. Raven Press, publisher, pp.264-271, 1996

15. Kleerekoper M, Rao DS, Talpos G, Bone H: Management of Asymptomatic Primary Hyperparathyroidism. Advances in Endocrinology and Metabolism, Vol 2, pp 205-220, 1991.

16. Edelson G, Kleerekoper M: Hyperparathyroidism and Hypoparathyroidism in Conn's Current Therapy. RE Rakel, Ed. WB Saunders publishers, pp 559-565, 1992.

17. Kleerekoper M, Mendlovic D: Osteoporosis in Conn's Current Therapy, RE Raken Ed, WB Saunders publishers, pp 566-570, 1993.

18. Kleerekoper M, Balena R: Fluorides and Osteoporosis in Annu Rev Nutr. R Olson Ed, AR CA Publishers, 11:309-24, Vol II, 1991.

19. Kleerekoper M: Fluoride in "Osteoporosis" J.C. Stevenson, R. Lindsay, Eds. Chapman and Hall, London (in press).

20. Kleerekoper M: Clinical Course of Primary Hyperparathyroidism, in "The Parathyroids. Basic and Clinical Concepts." J.P. Bilezikian, M.A. Levine, R. Marcus, Eds. Raven Press, New York pp.471-483, 1994.

21. Nelson DA, Kleerekoper M. Perspectives on morphometric and qualitative vertebral fracture assessment. In AVertebral Fracture in Osteoporosis@, HK Genant, M Jergas, C van Kuijk Eds., Radiology Research and Education Foundation, San Francisco, publishers. pp.361-70, 1995

22. Nelson DA, Kleerekoper M. What is a vertebral fracture. In AOsteoporosis@, R Marcus, D Feldman, J Kelsey Eds. Academic Press, San Diego, publisher, pp.613-621, 1996

23. Kleerekoper M: The evaluation of patients with osteoporosis. in AOsteoporosis@, R Marcus, D Feldman, J Kelsey Eds. Academic Press, San Diego, publisher, pp1011-8, 1996

24. Kleerekoper M: The epidemiology of osteoporosis. In "Osteoporosis: Diagnostic and therapeutic principles" CJ Rosen ed. Humana Press Totowa, New Jersey, publishers pp. 65-68, 1996

25. Edelson GW, Kleerekoper M: Pathophysiology of osteoporosis. In "Osteoporosis: Diagnosis and treatment", DJ Sartoris ed, Marcel Dekker, Inc., New York, publishers. pp. 1-18, 1996

26. Kleerekoper M.: Fluoride and the skeleton. in, "Principles of Bone Biology", JP Bilezikian, LG Raisz, GA Rodan eds., Academic Press, San Diego, publishers. pp. 1053-1062, 1996

27. Kleerekoper M, Avioli LV: Osteoporosis Pathogenesis and Therapy. In: "Metabolic Bone Disease and Clinically Related Disorders" LV Avioli and SM Krane (eds.), Academic Press 3rd edition, San Diego, publishers pp 387-409, 1997

28. Kleerekoper M, DA Nelson: Differential Diagnosis: Low Bone Mass. In "Osteoporosis in Clinical Practice: A Practical Guide for Diagnosis and Treatment" P Geusens (ed) Springer-Verlag Berlin Heidelberg New York publishers pp 73-76, 1997

29. Igwe R, M Kleerekoper: Endocrine & Hemoglobin-Related Arthropathies & Storage Diseases: Bone and Joint Abnormalities in Thyroid Disease. In "Rheumatology Second Edition, JH Klippel and PA Dieppe (eds) Mosby International, London, publishers pp 21.1-21.4, 1997

30. Kleerekoper M, R Igwe: Endocrine & Hemoglobin-Related Arthropathies & Storage Diseases: Hyperparathyroidism. In Rheumatology Second Edition, JH Klippel and PA Dieppe (eds) Mosby International, London, publishers pp (8)22.1-22.4, 1997

31. Kleerekoper M, Nelson DA: Fluoride therapy for Postmenopausal osteoporosis. In: Osteoporosis (eds) John C. Stevenson and Robert Lindsay, published by Chapman & Hall, London pp 277-292, 1998

32. Kleerekoper M, Nelson DA: Peripheral bone densitometry: an old friend revisited. In: Transactions of the American Clinical and Climatological Association, Vol 109, pp 62-72, 1998.

Published abstracts: (for last seven years)

    1. Cohen-Solal M, Shih M, Rao D, Mohini R, Kleerekoper M, Parfitt AM: Atypical Osteomalacia in dialysis osteodystrophy. J Bone Min Res 5(2):121, 1990.

    2. Kleerekoper M, Balena R, Foldes J, Shih M, Rao A, Parfitt AM: Histomorphometric changes in iliac bone induced by sodium fluoride therapy depend on cumulative dose. J Bone Min Res 5(2):267, 1990.

    3. Balena R, Wilson P, Kleerekoper M, Parfitt AM: Absence of racial differences in the PTH-vitamin D axis. Calc Tiss Int 548:A17, 1991.

    4. Nelson DA, Kleerekoper M, Peterson EL, Parfitt AM: The progression of spinal osteoporosis can be monitored by serial measurement of stature. Clinical Research, 1991.

    5. Nelson DA, Kleerekoper M, Havstad S, Peterson E: Vertebral deformities in osteoporosis may be transient events: " The Rebound" Phenomenon. Am Soc Bone & Min Res, August 22-29, 1991.

    6. Van Dellen S, Nelson DA, Kleerekoper M, Cruz C, Duncan H: Hypercalcemia in a patient with juvenile rheumatoid arthritis complicated by metastatic calcium deposits. Am Soc Bone & Min Res, August 22-29, 1991.

    7. Wilson P, Kleerekoper M: Acute response to calcitonin: Relationship to markers of bone remodeling. Am Soc Bone & Min Res. August 22-29, 1991.

    8. El-Choufi L, Nelson J, Kleerekoper M: Therapeutic options in postmenopausal osteoporosis. J Musculoskeletal Med, 1993 (in press).

    9. De Luca-Franchi R, Kleerekoper M, Mocetti P, Bonucci E: Osteoporosis secondary to systemic mastocytosis: Effectiveness of three years of therapy with ketotifen and H1 and H2 antagonists. Societa' Italiana Dell'Osteoporosi, 5o Congresso Nazionale, Padova 30 Novembre-3 Dicembre, 1993.

    10. Nelson DA, Flynn MJ, Jacobsen G, Kleerekoper M: Black/White Differences in vertebral cancellous bone density. Am Soc Bon & Min Res. September 18-22, 1993.

    12. Wilson P, Parikh N, Hill J, King N, Rao P, Rofe A, Kleerekoper M: Skeletal biochemistry in older healthy Black and White women: Reference data. Am Soc Bon & Min Res. September 18-22, 1993.

    13. Kleerekoper M, Nelson DA, Peterson E, Jacobson G: Kyphosis and lordosis: Ethnic differences, relation to stature, bone mineral density, and osteoporosis. Am Soc Bon & Min. Res. September 18-22, 1993.

    14. Farkas SI, Ragatzki P, Kleerekoper M: Spinal epidural lipomatosis, a rare complication of steroid therapy: American College of Physicians, Michigan Regional Chapter Annual Meeting, October 1994.

    15. Simpson PM, Kleerekoper M, Nelson DA, Lekas P: Biological variability in the evaluation of osteoporosis. Sixteenth Annual Meeting, Society for Clinical Trails, 1995.

    16. Kleerekoper M, Parikh N, Parfitt AM: Comparison of three methods for bone alkaline phosphatase. J Bone and Mineral Res: 10(supplement 1), 1995.

    17. Miller PD, Bonnick SL, Rosen CJ, Altman RD, Avioli LV, Dequeker J, Felsenberg D, Genant HK, Gennari C, Harper KD, Hodsman AB, Kleerekoper M, Mautalen CA, McClung MR, Meunier PJ, Nelson DA, Peel NF, Raisz LG, Recker RR, Utian WH, Wasnich RD, Watts NB: Clinical utility of bone mass measurements in adults: consensus of an international panel. The Society for Clinical Densitometry. Seminars in Arthritis & Rheumatism 25(6):361-72, 1996.

    18. Kleerekoper M: Biochemical markers of bone remodeling. Amer J Med Sci 312(6):270-277, 1996.

    19. Nelson DA, Simpson PM, Johnson CC, Barondess DA, Kleerekoper M: The accumulation of whole body skeletal mass in third-and fourth-grade children: effects of age, gender, ethnicity, and body composition. Bone 20(1):73-78, 1997.

Presentations:

1. Invited and/or refereed international or national meetings
1994 American Diabetes Association Postgraduate Assembly
invited symposium presentation

International Rehabilitation Medicine Association
invited symposium presentation

Endocrine Society Annual Meeting
invited symposium presentation

American Association for Clinical Chemistry Annual Meeting
invited workshop participant

First Annual Los Angeles Briefing on Women=s Health Problems
invited panelist

Brazilian Endocrine Society
invited plenary lecturer

Chilean Rheumatology Society
invited plenary lecturer

1995 Clinical Ligand Society Annual Meeting
invited workshop moderator and speaker

American Association for Clinical Chemistry Annual Meeting
invited workshop presentation
invited breakfast and lunch roundtable discussion leader

American Society for Bone and Mineral Research Annual Meeting
meet the professor roundtable discussion leader

International Society for Clinical Enzymology
invited plenary lecture

Second Annual Los Angeles Briefing on Womens Health Problems
invited panelist

1996 American Association for Clinical Chemistry Annual Meeting
invited workshop presentation
invited Edu-track presentation

American Society for Reproductive Medicine Annual Meeting
invited workshop presentation

International Society for Clinical Densitometry Annual Meeting
invited plenary lecture

WHO-ILAR conference on minimal standards for osteoporosis
invited lecture

American College of Obstetrics and Gynecology Annual Meeting
invited workshop presentation

American College of Obstetrics and Gynecology Region VI annual meeting
invited lecture

American Association for Rehabilitation Medicine Annual Meeting
invited workshop presentation

2. Invited and/or refereed local/regional meetings

  • Evaluation and management of osteoporosis at Michigan State Medical Society Annual Scientific Meeting, November 12, 1991.
  • Long term consequences of estrogen deprivation at St. Joseph Medical Center on September 25, 1991.
  • Metabolic bone diseases in children at Henry Ford Hospital Orthopedic Core Lecture Series on September 17, 1991.
  • CA MG Disorders at Henry Ford Hospital Department of Emergency Medicine Conference Series on September 11, 1991.
  • Osteoporosis: evaluation and management sponsored by Wayne State University/Hutzel Hospital on March 27, 1991 in Dearborn.
  • Bone metabolism in the handicapped child and the young adult at 7th Annual Developmental Disabilities Conference sponsored by Department of Mental Health on March 12, 1991.
  • Osteoporosis at Saginaw General Hospital on March 5, 1991.
  • Visiting professor program at Radisson Plaza Hotel, Southfield, on January 18, 1991.

3. Invited seminars or lectures presented

1992 Lectures:

  • 01/09/92 University of Alabama School of Medicine Endocrine Conference, "Tailored Therapy for Osteoporosis"
  • 01/30/92 Grace Hospital in Detroit, "Tailored Management in Osteoporosis"
  • 02/06/92 Mt. Clemens General Hospital Internal Medicine Grand Rounds, "The Long Term Consequences of Estrogen Deprivation"
  • 02/20/92 St. Catherine Hospital of East Chicago, Internal Medicine Grand Rounds, "Long Term Consequences of Estrogen Deprivation"
  • 02/22/92 Windemere Communications, Queen Elizabeth Hotel, Montreal, "Hormone Replacement Therapy 1992: Practical Approaches"
  • 03/06/92 Beaumont Hospital Intensive Review of Geriatric Medicine at Northfield Hilton in Troy, "Osteoporosis in the Elderly"
  • 03/25/92 Geisinger Medical Center in Dansville, PA, "Postmenopausal Osteoporosis"
  • 03/28/92 Windemere Communications, Ottawa, "Hormone Replacement Therapy in 1992: Practical Approaches"
  • 03/29/92 Meadowbrook Hall, Toledo, Ohio, "Role of Estrogen Replacement Therapy in Osteoporosis Prevention"
  • 04/05/92 University of Toledo College of Pharmacy Annual Continuing Education Seminar, Cleveland, OH, "Role of Estrogen Replacement Therapy in Osteoporosis Prevention"
  • 04/07/92 Central Maine Medical Center Internal Medicine Grand Rounds, "Long Term Consequences of Estrogen Deprivation"
  • 04/08/92 Current Concepts in Postmenopausal Hormone Replacement Conference in Grand Rapids, MI, "Long Term Consequences of Estrogen Deprivation"
  • 04/24-29/92 International Conference on Calcium Regulating Hormones, Florence, Italy, "Effect of Body Size on Bone Mass"
  • 05/02/92 Windemere Communications, Toronto, "Hormone Replacement Therapy 1992: Practical Approaches"
  • 05/22-23/92 Bay Valley Resort, Bay City, MI, "Osteoporosis"
  • 06/02/92 St. Charles Hospital, Oregon, OH, "Osteoporosis"
  • 06/5-6/92 National Osteoporosis Foundation, Cleveland, OH, "Clinical Use of Bone Mass Measurement" and "Osteoporosis in Men"
  • 06/28-30/92 Long Term Effects of Estrogen Deprivation in San Diego, CA, "Measurement of Bone Turnover and Prediction of Risk Factors"
  • 07/20/92 American Association of Clinical Chemistry 44th National Meeting, Chicago, IL, "Osteoporosis"
  • 08/01/92 University of Michigan Continuing Medical Education Conference, Grand Traverse, MI, "Endocrinology and Diabetes Update"
  • 08/15/92 Wyeth-Ayerst Visiting Professor Program, Mission Point Resort, Mackinac Island, "Estrogen Replacement Therapy"
  • 09/17-18/92 Annual Dialysis Symposium, Chicago, "Uremic Osteodystrophy"
  • 10/8-9/92 Update on Clinical Endocrinology, Milwaukee, WI, "Tailored Therapy for Osteoporosis"
  • 10/20/92 Wyeth-Ayerst Visiting Professor Program, Garden City Hospital, "Estrogen Replacement Therapy"
  • 10/21/92 Wayne State University Symposium on Osteoporosis, Dearborn Inn, Dearborn, MI "Prevention and Management"
  • 11/02/92 Oakwood Hospital Subspecialty Conference, "Hyperparathyroidism"
  • 11/04/92 Wayne State University School of Medicine Continuing Medical Education Endocrinology Review, Grand Manor at Fairlane, "Management of Osteoporosis"
  • 11/12-14/92 National Osteoporosis Foundation, San Antonio, Texas, "Clinical Use of Bone Mass Measurement" and "Other Therapeutic Options in Osteoporosis"
  • 11/19-20/92 Bon Secours Continuing Medical Education Series, "Osteoporosis: Prevention, Evaluation, and Therapy"
  • 11/19-20/92 Frank and Sheila Thompson Lectureship in Endocrinology, Scott and White, Temple, Texas, "Tailored Therapy for Osteoporosis" and "Who Should Have Parathyroidectomy for Primary Hyperparathyroidism"
  • 11/21/92 Osteoporosis Update Conference sponsored by ProMedica, New York, "Prediction of those at Risk for Osteoporosis"
  • 11/30/92 St. John Hospital Continuing Medical Education Program, "Bone Metabolism/Osteoporosis"

1993 Lectures

  • 01/13/93 NIH, Bethesda, MD, "Methods for Assessing Fluoride Accumulation and Effects in the Body"
  • 02/12/93 University of Texas Health Science Center in Antonio, Post Graduate Endocrinology Course
  • 03/09/93 Manchester Memorial Hospital, Manchester, CT
  • 03/22-24/93 NIH Workshop on Menopause
  • 04/14/93 Rheumatology Conference at Sinai Hospital
  • 04/15/93 Lecture to General Staff at Middlesex Hospital in Connecticut
  • 04/22/93 Clinical Ligand Society, Ritz Carlton, Dearborn, MI
  • 04/24-30/93 European Symposium on Calcified Tissues, Heidelberg
  • 05/11/93 Providence Hospital Lecture, sponsored by Wyeth-Ayerst
  • 06/26/93 Clinical Management of the Patient with Osteoporosis sponsored by the NOF and the University of Washington School of Medicine, Four Seasons Olympic Hotel, Seattle
  • 07/20/93 Program at Flower Hospital, Sylvania OH, sponsored by Wyeth-Ayerst
  • 07/30/93 73rd Coller Penberthy Thirlby Medical Conference, Park Place Hotel in Traverse City
  • 08/21/93 Burns Clinic in Petoskey, Medical Education Conference Series
  • 10/09/93 National Osteoporosis Foundation, Hotel Nikko, "Clinical Management of the Patient with Osteoporosis"
  • 10/30/93 AACE Bone Seminar, Mt. Sinai Medical Center, New York: "Male Osteoporosis"
  • 11/16/93 University of Michigan Medical Center, Department of Internal Medicine, Endocrinology and Metabolism, Clinical Conference: "Metabolic Bone Disease"
  • 11/17/93 University of Tennessee, Memphis: Osteoporosis research and calcium metabolism

1994 Lectures

  • 06/6-8/94 Consensus Development Conference on Calcium, Sponsored by NIAMS, OMAR, and NIH, Bethesda, MD: Medications and Secondary Osteoporosis
  • 07/17-21/94 AACC 46th National Meeting and Clinical Laboratory Exposition, New Orleans LA: "Circulating Markers of Bone Metabolism: Roles in Diagnosis, Monitoring, and Treatment of Skeletal Disease".
  • 07/31/94 Endocrinology and Diabetes Update, Grand Traverse, MI

1995 Lectures

  • 01/12/95 Medical College of Ohio, Toledo, Ohio: OB/GYN Grand Rounds
  • 01/19/95 Methodist Hospital & Indiana University, Indianapolis, IN: Primary Care Physicians and Osteoporosis.
  • 04/03/95 Lecture Beaumont Hospital, Troy, MI

1996 Lectures

  • 1/4/97 Grand Rounds, University of S. Alabama
  • 1/22/97 Sinai Hospital, Detroit, MI
  • 2/29/97 St. Joseph Hospital, Ann Arbor, MI
  • 1/30/97 Grand Rounds, St. Johns Hospital, Detroit, MI
  • 3/5/97 Grand Rounds, Hutzel Hospital, Detroit, MI
  • 3/6/97 Grand Rounds, Heritage Hospital, Taylor, MI
  • 3/27/97 Grand Rounds, Tucson Medical Center, Tucson, AZ
  • 3/29/97 Grand Rounds, Phoenix, AZ
  • 4/29/97 ACOG Symposium, Denver, CO
  • 5/15/97 Blodgett Medical Center, Grand Rapids, MI
  • 5/29/97 Physician Medical Group, South Bend, IN
  • 6/6/97 Grand Rounds, U of M Ob/Gyn, Ann Arbor, MI
  • 9/6/97 Grand Rounds, Ob/Gyn Northwestern University, Chicago, IL

1997 Lectures

  • 10/08/97 Kresge Eye, Detroit, MI
  • 11/12/97 Grand Rounds, Pontiac Osteopathic Hospital, Pontiac, MI
  • 11/20/97 Northwestern University, Chicago, IL

1998 Lectures

  • 01/30/98 Oakwood Hospital, Allen Park, MI
  • 02/07/98 Grand Rounds, Ford Hospital, Detroit, MI
  • 02/11/98 Endocrine Rounds, John Hopkins Hospital,
  • 02/17/98 Grand Rounds, Henry Ford Hospital, Detroit, MI
  • 03/03/98 Ob/gyn, Hutzel Hospital, Detroit, MI
  • 03/11/98 Geriatrics lecture, Wayne State University, Detroit, MI
  • 03/13/98 Rheumatology Core Curriculum, Hutzel Hospital