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Research Interests and Goals:
Physiology and pathology of male and
female reproduction. Stimulators, modulators and regulators of spermatogenesis
and spermiogenesis. Stimulators, modulators, and regulators of folliculogenesis
and ovulation. Mechanism of action of gonadotropins and growth factors on gene
expression and steroidogenesis. Molecular mechanism of cell proliferation and
cell death in hormone dependent tumors.
Previous and Current Research:
Characterized the chemical and
biological nature of human menopausal gonadotropins and discovered their use in
male and female infertility. With his collaborators he established a diagnostic,
therapeutic oriented, classification system for male and female infertility.
Proposed guidelines for the management of infertility and designed effective
treatment protocols. Research focused on the understanding of mechanisms
controlling the hypothalamic-pituitary gonadal and adrenal axis and in the
understanding of the nature, development and pathogenesis of diseases leading to
functional abnormalities in this axis. Current research involves: 1) subcellular
and molecular nature of granulosa cell response to gonadotropins, growth factors
and binding globulins. 2) Effects of gonadotropins on spermatogenesis and
spermiogenesis.
Interests and Future projects:
The mode of action of gonadotropins,
growth factors and their binding globulins in ovarian and testicular regulation
and function. The application of results of such basic research to clinical
diagnostic preventive and therapeutic strategies. Development of strategies in
teaching and transfer of technology related to endocrinology and reproduction.
- M.D. Medical School, University
Geneva, 1954
- Visiting Scientist, Weizmann
Institute of Science (1957-1961)
- Director Institute of Endocrinology
(1961- 1992);
- Chairman Research & Ethical
Committee (1977-1981) Sheba Medical Center
- Since 1967 Consultant and Member of
various committees, World Health Organization (WHO)
- Joined Bar-Ilan University in 1967
and Founded and Headed the Department of Life Sciences in 1969
- Full Professor since 1969
- Fellow Ad Eundum Royal College of
Obstetrics and Gynecologists, U.K. (FRCOG) since 1981
- Counselor Extern. Relations &
Head Dept. Internat. Relations (1971-1985);
- Acting Chief Scientist (1984-1986),
Ministry of Health
- President - Israel Fertility
Association (1979- 1983); Israel Endocrine Society (since 1991)
- Vice President Scientific Council,
Israel Medical Association since 1990 Honorary Fellow of the American
College of Obstetricians & Gynecology (FACOG hon.) 1991 & Honorary
Member - Italian & French Society of Gynecology; The German Endocrine
Society; The Austrian Society of Fertility and Sterility.
- Since 1989 Member of Executive
Council Intern. Soc. of Gynecology. Endocrinology and Intern. Committee of
Research in Reproduction;
- Founder and organizer of the
International Symposiums on GnRH Analogues in Cancer and Human Reproduction;
International Symposiums on the Aging Male;
- 492 publications, 350 in refereed
journals, 112 Reports, Reviews & Chapters in Books and Author, Co-Author
or Editor of 30 books.
- 50 students (5 Ph.D., 12 M.Sc. and
33 M.D.) have been supervised in his laboratory and 4 (1 Ph.D. and 3 M.Sc.)
are currently enrolled.
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