About the author
Linda C. Giudice, PhD, MD
Chief, Reproductive Endocrinology & Infertility
Stanley McCormick Memorial Professor in the School of Medicine
Director, Women’s Health @ Stanford
Director, Center for Research on Women’s Health and Reproduction
Professor of Gynecology and Obstetrics
Chief, Div. Reproductive Endocrinology and Infertility
Associate Chair of Research, Department of Obstetrics and Gynecology
300 Pasteur Drive, HH-333
Stanford, CA 94305-5317
Tel: 650-498-7317
Publications in Textbooks
1. Giudice LC: Structural Studies on the Glycoprotein Hormones, Lutropin
and Thyrotropin, Ph.D. Dissertation, University of California, Los
Angeles, 1976.
2. Giudice LC, Pierce JG: Glycoprotein Hormones: Some Aspects of Studies
of Secondary and Tertiary Structure. In: McKerns KW, ed., The
Gonadotropins: Structure and Function, Plenum, New York, 81-110, 1978.
3. Giudice LC: Cell-Free Synthesis and Immunoprecipitation of Precursor
Forms of Thyroid Stimulating Hormone a and b Subunits, The Ligand
Review, Summer, 1979.
4. Chaiken IM, Fischer EA, Giudice LC, Hough CJ: In Vitro Synthesis of
Hypothalamic Neurophysin Precursors. In: McKerns KW, Pantic V, eds.,
Hormonally Active Brain Peptides, Plenum, New York, 327-347, 1982.
5. Giudice LC: The Endocrinology of Recurrent Spontaneous Abortion. In:
Ueland K, Brody SA, eds, Endocrine Disorders in Pregnancy,
Appleton-Century-Crofts, New York, 467-481, 1989.
6. Giudice LC: The Insulin-like Growth Factor Autocrine-Paracrine System
and Its Role in Ovarian Folliculogenesis. In: Frontiers Repro
Endocrinol, Serono Symp, Boston, 95-108, 1991.
7. Giudice LC, Rosenfeld RG: Growth Factors in Reproduction. In: Dunaiff
A, Givens J, Merriam G, eds, Polycystic Ovary Syndrome, Blackwell
Scientific, Oxford, 201-211, 1991.
8. Crystal RA and Giudice LC: Insulin-like Growth Factor Binding Protein
(IGFBP) Profiles in Human Fetal Cord Sera: Ontogeny During Gestation and
Differences in Newborns with Growth Retardation and Large for
Gestational Age Newborns, In: Spencer EM, ed, Modern Concepts of
Insulin-like Growth Factors, Elsevier, New York, 395-408, 1991
9. Giudice, LC: Hormonal Control of Insulin-like Growth Factors, Their
Binding Proteins, and Receptors in Human Endometrium, In: Opportunities
in Contraception: Research and Development, N. Alexander and C.
d’Arcangues, eds, Amer Assoc Advan Sci Press, 255-262, 1992.
10. Giudice LC: RU486 and Other Antiprogestins: Political and Medical
Implications. In, Proceedings of the Symposium on the Future of RU486
(The Abortion Pill) in America: Medical, Ethical, and Political Issues,
Raffin TA and Young E, eds, Stanford University Center for Biomedical
Ethics, Stanford University Press, February 1993.
11. Giudice LC, Irwin JC, Dsupin BA, de las Fuentes L, Jin IH, Vu TH,
Hoffman AR: Insulin-like Growth Factors (IGFs), IGF Binding Proteins (IGFBPs),
and IGFBP Protease in Human Uterine Endometrium: Their Potential
Relevance to Endometrial Cyclic Function and Maternal-embryonic
Interactions. In: The Insulin-like Growth Factors and Their Regulatory
Proteins. Baxter RC, Gluckmann PD, Rosenfeld RG. Excerpta Medica
International Congress Series 1056, Amsterdam, 351-361, 1994.
12. Giudice LC: Overview of the Endometrium in Reproductive Medicine.
In: Infertility and Reproductive Medicine Clinics of North America: The
Endometrium. Metzger DA, ed. WB Saunders Co, Philadelphia,
1995;6:263-280.
13. Giudice LC, Ferenczy A: The Endometrial Cycle: Morphologic and
Biochemical Events. In: Reproductive Endocrinology, Surgery, and
Technology. Adashi EY, Rock JA, Rosenwaks Z, eds, Raven Press, New York,
1995;1:171-194.
14. Giudice LC: Insulin-like Growth Factors and Their Binding Proteins
in Normal and Abnormal Human Ovarian Follicle Development. Frontiers in
Endocrinology, vol 13. New Achievements in Search of Ovarian Function,
eds, S Fujimoto, AJW Hsueh, JF Strauss, III, T Tanaka. Ares-Serono
Symposia Publications, Rome, 127-134, 1995.
15. Giudice LC: Growth Factors, Cytokines, and Implantation. Serono
Symposia Series, Frontiers in Endocrinology: Gonadal Function- Genetics
to Physiology, Springer-Verlag, New York, 1995;18:151-159.
16. Giudice LC, van Dessel HJHM, Cataldo NA, Chandrasekher YA, Yap OWS,
Fauser BCJM: Circulating and Ovarian IGF Binding Proteins (IGFBPs):
Potential Roles in Normo-ovulatory Cycles and in Polycystic Ovarian
Syndrome. Progress in Growth Factor Research, Elsevier Science Ltd,
Oxford. 1995; 397-408.
17. Giudice LC, van Dessel HJHM, Cataldo NA, Chandrasekher YA, Yap OWS,
Fauser BCJM: The Insulin-like Growth Factor (IGF) System in Human Ovary
and Its Relevance to Polycystic Ovarian Syndrome. In: Polycystic Ovarian
Syndrome, ed: RJ Cheng, Serono Symposia USA, Springer-Verlag, New York,
223-244, 1996.
18. Giudice LC, van Dessel HJHM, Cataldo NA, Chandrasekher YA, Yap OWS,
Fauser BCJM: Insulin-like growth factors and their binding proteins:
their potential relevance to normal and abnormal follicle development in
human ovary. Serono Symposia Series: Frontiers in Endocrinology, vol 19,
The Role of Insulin-like Growth Factors in Ovarian Physiology, D Le
Roith ed, 219-232, 1996.
19. Giudice LC: Biochemical Events in the Endometrium During the
Menstrual Cycle and Implantation. In: Infertility, Contraception, and
Reproductive Endocrinology. Lobo RA, Mishell DR, Paulson RJ, eds.
Blackwell Scientific Publications, Inc, Cambridge, 141-158, 1997.
20. Giudice LC: Involvement of Growth Factors in Polycystic Ovary
Syndrome. In: Polycystic Ovary SyndromeMartin Dunitz Publishers, London,
1997.
21. Giudice LC, Chandresekher YA, Cataldo NA, van Dessel T, Saleh W, Yap
OWS, Ulaner GA. Growth Factors and Cytokines in the Reproductive Tract
of Women: Physiology and Pathophysiology. In: Growth Factors and
Cytokines in Health and Disease, eds: D Le Roith and C Bondy, JAI Press,
Inc, Greenwich, Conn, 1997, vol 3A, pp 223-291.
22. Giudice LC: Role of Insulin-like Growth Factors (IGFs) and IGF
Binding Proteins in PCOS. In: Androgen Excess Disorders in Women. R
Azziz, JE Nestler, D Dewailly eds, Lippincott-Raven Publishers,
Philadelphia. 1977, pp 507-519.
23. Giudice LC. The Human Ovarian Insulin-like Growth Factor System. In:
FSH Action and Intraovarian Regulation. Studies in Profertility Series,
Parthenon Publishing Group, New York, vol 6, 1997, pp 1119-135.
24. Giudice LC. Advanced Reproductive Technologies: Bane or Boom? In:
Blechman EA and Brownell KD (eds). Behavioral Medicine for Women: A
Comprehensive Handbook, Blackwell Science, Inc., Cambridge. 1997, pp
515-519.
25. Giudice LC. Multifaceted Roles for Insulin-like Growth Factor
Binding Protein-1 in Implantation and Pregnancy. Ann NY Acad Sci 1997,
200-217.
26. Giudice LC. Reproductive Endocrinology. Merck Manual, 17th edition,
1998.
27. Giudice LC. Infertility. Merck Manual, 17th edition, 1998.
28. Giudice LC Menstrual Abnormalities and Abnormal Genital Bleeding.
Merck Manual, 17th edition, 1998.
29. Giudice LC. Endometriosis. Merck Manual, 17th edition, 1998.
30. Swiersz L, Giudice LC. Unexplained Infertility and the Role of
Uterine Receptivity. In Infertility Clinics of North America, 1997, vol
8, pp 523-543.
31. Giudice LC. Intimate Conversations Between the Implanting Conceptus
and Its Maternal Host. ORGYN, 1997, VIII:48-51.
32. Giudice LC. Insulin-like Growth Factors and Other Endometrial
Modulators in Endometrial Development and Endometriosis. In: Diamond M,
Osteen KG (eds). Endometrium and Endometriosis. Blackwell Science, Inc,
Cambridge, 1997. pp 333-341.
33. Giudice LC. The Endometrium. In: Encyclopedia of Reproduction, ed E
Knobil and JD Neill, Academic Press, San Diego, 1998, pp 1067-1077.
34. Irwin JC, Giudice LC. The Decidua. In: Encyclopedia of Reproduction,
ed E Knobil and JD Neill, Academic Press, San Diego, 1998, 823-835.
35. Tazuke S, Giudice LC. Myometrium and Leiomyoma. In: Encyclopedia of
Reproduction, ed E Knobil and JD Neill, Academic Press, San Diego, 1998,
991-999.
36. Giudice LC. Growth Factors and Polycystic Ovarian Syndrome.
Polycystic Ovarian Syndrome. Cuadernos de Medicina Reproductive, R
Homberg, editor, 1998; 101-119.
37. Giudice LC. Human Endometrium as a Paracrine Organ Hormonally
Regulated. Cuadernos de Medicina Reproductive Editorial Medica
Panamericana SA, 1999, in press.
38. Giudice LC. Implantation and Endometrial Function. In: Molecular
Biology in Clinical Reproductive Medicine, BCJM Fauser, AJ Rutherford,
JF Strauss, A van Steirteghem, eds. Parthenon Publishing, Newe York.
1999, pp 333-352.
39. Giudice LC. Insulin-like growth factor family in the female
reproductive system. In: Rosenfeld RG and Roberts CR, eds. The IGF
System: Molecular Biology, Physiology, and Clinical Applications. Humana
Press, Totowa, NJ, 1999, pp379-406.
40. Giudice LC. Growth Factor Action on Ovarian Function in Polycystic
Ovarian Syndrome. Endocrinol Metab Clinics No Amer 1999;28:325-340.
41. Kao LC, Giudice LC. Growth factors and implantation. Infertility
Clinics of North America, 2001, 12:281-299.
42. Giudice LC: Involvement of Growth Factors in Polycystic Ovary
Syndrome – An Update on the Insulin-like Growth Factor System. In:
Polycystic Ovary Syndrome. Martin Dunitz Publishers, London, 2002, in
press.
43. Westphal LM, Chen B, Tazuke SI, Giudice LC. Disorders of the
Endometrium: Abnormal Bleeding, Endometriosis, Adenomyosis and
Implantation. Infertility Clinics of North America, 2003, in press.
44. Telles TL, Giudice LC. Common Problems in clinical reproductive
Endocrinology. In: Practical Infertility Management - Inviting Success.
Shah U, Allahbadia G, eds. Orient Longman Lmt, India, 2002 pp 2-26.
45. Giudice, LC. Implantation and endometrial function. In: Reproductive
Medicine: Molecular, Cellular and Genetic Fundamentals. Bart C.J.M.
Fauser, Ed. 2002, pp.439-465.
Edited Monographs
1. Growth Factors in Endometrium. Seminars in Reproductive
Endocrinology, volume 13, no 2, eds LC Giudice, ML Polan, Thieme Publ,
1995, pp 93-171.
2. Growth Factors in Reproduction. Seminars in Reproductive
Endocrinology, volume 14, no 3, LC Giudice, editor, Thieme Publ, 1996,
pp175-282.
3. Implantation. Seminars in Reproductive Medicine. S.K. Dey and LC
Giudice, eds. 2001 Vol 18, pp225-326.
4. Molecular Aspects of Implantation and Embryonic Development. Reviews
in Endocrine and Metabolic Disorders. Guest Editor, LC Giudice. Editor,
D LeRoith, Kluwer Academic Publishers, Vol 3, No 2, May 2002, pp439-465.
5. The Endometrium. Eds S Glasser, J Aplin, LC Giudice, Tabibzadeh S.
Taylor and Francis Publishers, London. Publication date: May 24, 2002.
Abstracts
1. Spaeth EE, Giudice LC: The Role of Convective Diffusion in the
Interaction of Blood Proteins with Artificial Surfaces. Symposium on
Engineering Problems in Artificial Organs, Third Joint Puerto Rico AIChE/IIOPR
Meeting, San Juan, May 1970.
2. Spaeth EE, Giudice LC, Yin ET: The Activation of Blood Clotting
Factors at Artificial Surfaces. Paper #36D, Symposium on Fundamental
Research on Interfacial Phenomena, 64th Annual AIChE Meeting, San
Francisco, November 1971.
3. Spaeth EE, Mohandas N, Giudice LC, Hogmuth RM: Adhesion of Blood
Cells to Artificial Surfaces in the Presence of Flow. Symposium on
Polymeric Materials in Artificial Organs, California Institute of
Technology, November 1971.
4. Giudice LC, Pierce JG: Regeneration of a Functional a-Subunit of
Luteinizing Hormone After Complete Reduction and Reoxidation of Its
Disulfide Bonds. Federation Proceedings, 35, 1527, 1976.
5. Giudice LC, Weintraub BD: Cell-Free Biosynthesis, Specific
Immunoprecipitation, and Processing of TSH Pre-a and Pre-b Subunits.
Endocrine Society, Anaheim, Abstract 83, 1979.
6. Giudice LC, Waxdal MJ, Weintraub BD: Cell-Free Biosynthesis and
Sequence Homology of Bovine and Mouse Pituitary Glycoprotein Hormone
Pre-a Subunits. XI International Congress of Biochemistry, Toronto,
Abstract 03-1-57, 1979.
7. Giudice LC, Farrell EM, Lamson G, Rosenfeld RG, Hintz RL: Expression
of mRNAs Encoding Insulin-like Growth Factors and Their Binding Proteins
in Human Endometrium. Society for Gynecologic Investigation, San Diego,
California, March 15-18, 1989.
8. Giudice LC, Lamson G, Oh Y, Pham H, Rosenfeld RG: A Unique
Insulin-like Growth Factor Binding Protein in a Human Endometrial Cell
Line, HEC IA. Endocrine Society 71st Annual Meeting, Seattle,
Washington, June 21-24, 1989.
9. Giudice LC, Lamson G, Farrell EM, Rosenfeld RG: Messenger RNAs
Encoding High and Low Molecular Weight Forms of Insulin-like Growth
Factor Binding Proteins Are Expressed in Human Placenta and Endometrium.
American Fertility Society, San Francisco, California, November 11-16,
1989.
10. Giudice LC, Farrell EM, Pham H, Rosenfeld RG: Identification of
Insulin-like Growth Factor Binding Protein-3 (IGF-BP-3) and IGF-BP-2 in
Human Follicular Fluid. Society for Gynecologic Investigation, St.
Louis, Missouri, March 21-24, 1990.
11. Giudice LC, Farrell EM, Irwin JC, Gwatkin RBL: Synthesis of
Insulin-like Growth Factor Binding Proteins in Cultured Human
Endometrial Stromal Cells. Serono Symposium on Growth Factors in
Reproduction, Savannah, Georgia, April 1-4, 1990.
12. Deal C, Lamson G, Giudice LC, Rosenfeld RG: Insulin-like Growth
Factor Binding Proteins (IGFBPs) Are Produced by Human Placental
Trophoblasts in Monolayer Culture. Serono Symposium on Growth Factors in
Reproduction, Savannah, Georgia, April 1-4, 1990.
13. Moossazadeh J, Giudice LC: The Use of a GnRH Agonist in the
Treatment of Uterine Adenomyoma. Thirty-eighth Annual Clinical Meeting
of the American College of Obstetricians and Gynecologists, San
Francisco, California, May 7-10, 1990.
14. Giudice LC, Farrell EM, Pham H, Lamson G, Rosenfeld RG: Insulin-like
Growth Factor Binding Proteins (IGFBPs) in Serum During Pregnancy and
the Puerperium: Depletion of IGFBP-3 by Endogenous Pregnancy-Associated
Activity. The Endocrine Society, Atlanta, Georgia, June 20-23, 1990.
15. Giudice LC, Lamson G, Rosenfeld RG, Regula D, Irwin JC, Gwatkin RBL:
Insulin-like Growth Factor Binding Proteins in Human Endometrium: mRNA
Expression, Protein Synthesis, and Cellular Localization. VII World
Congress on Human Reproduction, Helsinki, Finland, June 26-July 1, 1990.
16. Giudice LC, Milkowski D, El-Danasouri I: Human Luteinizing Granulosa
Cells Express Messenger RNA Encoding Insulin-like Growth Factor Binding
Proteins (IGFBPs), and Cultured Granulosa Cells Secrete IGFBPs Into
Conditioned Medium. American Fertility Society, Washington, D.C.,
October 13-18, 1990.
17. Crystal RA and Giudice LC: Altered Serum Insulin-like Growth Factor
Binding Protein Profiles in Human Fetal Cord Sera from Babies with
Growth Retardation and Large for Gestational Age Babies. Second
International Symposium on Insulin-like Growth Factors/Somatomedins, San
Francisco, January 12-16, 1990.
18. Giudice LC and Dsupin BA: Species Specificity of
Pregnancy-associated Insulin-like Growth Factor Binding Protein
Protease. Second International Symposium on Insulin-like Growth
Factors/Somatomedins, San Francisco, January 12-16, 1990.
19. Deal CL, Giudice LC, Lamson G, Rosenfeld RG: Production of
Insulin-like Growth Factors (IGFs) and Insulin-like growth factor
Binding Proteins (IGFBPs) in Human Trophoblasts. Second International
Symposium on Insulin-like Growth Factors/Somatomedins, San Francisco,
January 12-16, 1990.
20. Rosenfeld RG, Oh Y, Beukers MW, Pham H, Cohen P, Deal C, Fielder P,
Donovan S, Neely EK, Giudice LC, Ling N, Lamson G: Insulin-like Growth
Factor Receptor Physiology, Second International Symposium on
Insulin-like Growth Factors/Somatomedins, San Francisco, January 12-16,
1990.
21. Cataldo NA and Giudice LC: Insulin-like Growth Factor Binding
Protein Profiles in Follicular Fluid Correlate with Follicular
Functional Status. Society for Gynecologic Investigation, San Antonio,
March, 1991.
22. Cataldo NA and Giudice LC: Follicular Fluid Insulin-like Growth
Factor Binding Protein Profile in Polycystic Ovarian Syndrome. Society
for Gynecologic Investigation, San Antonio, March, 1991.
23. Giudice LC, Dsupin BA, Milkowski DA, Irwin JC: Identification of
Insulin-like Growth Factor Binding Proteins in Human Oviduct. Pacific
Coast Fertility Society, Indian Wells, April 10-14, 1991.
24. Cataldo NA, Dsupin BA, Giudice LC: Human Granulosa Contain mRNA
Encoding the 24kDa Insulin-like Growth Factor Binding Protein-4
(IGFBP-4), and Atretic but not Estrogenic Follicles Contain a 24kDa
IGFBP. The Endocrine Society, Washington D.C., June, 1991.
25. Giudice LC, Crystal RC, Dsupin BA: Insulin-like Growth Factors
Binding Proteins in the Human Fetus. The Endocrine Society, Washington
D.C., June, 1991.
26. Giudice LC, Dsupin BA, Irwin JC: Insulin, Progesterone, and
Epidermal Growth Factor Synergistically Regulate Human Endometrial
Insulin-like Growth Factor Binding Proteins (IGFBPs). American Fertility
Society, Orlando, October, 1991.
27. Giudice LC, Grogan BD, Cataldo NA, Wilson DM: Insulin-like Growth
Factor-I (IGF-I) and IGF Binding Proteins (IGFBPs) in Sera and
Follicular Fluid from a Patient Undergoing Ovulation Enhancement with
Adjuvant Growth Hormone (GH). American Fertility Society, Orlando,
October, 1991.
28. Cataldo NA, Wu T-F, Giudice LC: Human Luteinizing Granulosa Cells
Cultured in Defined Medium Produce Insulin-like Growth Factor Binding
Proteins (IGFBP). American Fertility Society, Orlando, October, 1991.
29. Giudice LC, Dsupin BA, Stouffer RL, Zelinski-Wooten MB, and
Fazleabas AT: Comparison of Insulin-like Growth Factor Binding Protein-3
(IGFBP-3) Protease Activity in Nonpregnancy and Pregnancy Sera from
Humans and Nonhuman Primates and Characterization of the Human Enzyme.
Society for Gynecologic Investigation, San Antonio, March, 1992.
30. Giudice LC, Dsupin BA, Jin IH, Vu T, Hoffman AD: Differential
expression of mRNAs Encoding Insulin-like Growth Factors and Their
Receptors in Human Endometrium Throughout the Menstrual Cycle and During
Early Pregnancy. Society for Gynecologic Investigation, San Antonio,
March, 1992.
31. Cataldo NA, Woodruff TK, Wu T-f, Giudice LC: Effects of Insulin-like
Growth Factors (IGF-I and IGF-II) and Growth Hormone (GH) on Production
of IGF Binding Proteins (IGFBPs) by Human Luteinizing Granulosa Cells.
Society for Gynecologic Investigation, San Antonio, March, 1992.
32. Irwin JC, Dsupin BA, Giudice LC: Insulin (I) and Insulin-like Growth
Factors (IGFs) Differentially Regulate the Secretion of IGF Binding
Proteins (IGFBPs) by In Vitro Decidualized Human Endometrial Stromal
Cells. Society for Gynecologic Investigation, San Antonio, March, 1992.
33. Giudice LC, Dsupin BA, Vu TH, Jin IH, Hoffman AR: Differential
Expression of Insulin-like Growth Factor (IGF-I), IGF-II, and Type I and
Type II Receptor Messenger RNAs in Human Oviduct. Pacific Coast
Fertility Society, Indian Wells, April, 1992, Abstract No. A4.
34. Milki A, Hardy RI, El Danasouri I, Giudice LC, Lamb EJ.
Intrafallopian Transfer Under Local Anesthesia in an Outpatient Clinic
Setting. Pacific Coast Fertility Society, Indian Wells, April, 1992,
Abstract No. A22.
35. El Danasouri I, Milki A, Giudice LC, Polan ML, Lamb EJ.
Fertilization and Cleavage After Zona Puncture of Oocytes by Sperm with
Partial Acrosome Aplasia. Pacific Coast Fertility Society, Indian Wells,
April, 1992, Abstract No. A14.
36. Irwin JC, Dsupin BA, Giudice LC: Steroid and Peptide Regulation of
Metalloprotease Secretion by Human Endometrial Stromal Cells is
Dependent on Stromal Differentiation. Endocrine Society, San Antonio,
June, 1992.
37. Pannier E, Irwin JC, Giudice LC: Synthesis, Secretion, and
Regulation of Insulin-like Growth Factor Binding Proteins (IGFBPs) by
Human Fetal Tissues. Endocrine Society, San Antonio, June, 1992.
38. Giudice LC, Dsupin BA, Irwin JC, Navre M: Type IV Collagenase mRNA
is Differentially Expressed in Human Endometrium During the Menstrual
Cycle and in Early Pregnancy. Ninth International Congress of
Endocrinology, Nice, August 1992.
39. Crystal RA, De Las Fuentes L, Giudice LC: Urinary Insulin-like
Growth Factor Binding Protein Profiles in Human Pregnancy. Ninth
International Congress of Endocrinology, Nice, August 1992.
40. Giudice LC, de Zegher F, Dsupin BA, de las Fuentes L, Crystal RA,
Gargosky SE, Rosenfeld RG, Hintz RL. Insulin-like Growth Factor Binding
Proteins in the Human Fetus and Neonate. Second International Workshop
on Insulin-like Growth Factor Binding Proteins, August, 1992, Opio,
France.
41. Giudice LC, Dsupin BA, Pannier E, Irwin JC. IGFBP Gene Expression
and Protein Synthesis by Human Uterine Leiomyomata (Fibroids) and
Uterine Myometrium. Second International Workshop on Insulin-like Growth
Factor Binding Proteins, August, 1992, Opio, France.
42. Irwin JC, Dsupin BA, de las Fuentes L, Giudice LC. Insulin Regulates
IGFBP-1 Production in Human Endometrial Stromal Cells. Second
International Workshop on Insulin-like Growth Factor Binding Proteins,
August, 1992, Opio, France.
43. Pannier E, Irwin JC, Giudice LC. Regulation and Identification of
IGFBPs Secreted by Human Fetal Tissues. Second International Workshop on
Insulin-like Growth Factor Binding Proteins, August, 1992, Opio, France.
44. Crystal RA, de las Fuentes L, Giudice LC. Identification of IGFBPs
in Human Urine from Pregnant Women with Normal Kidney Function and From
a Patient with Abnormal Kidney Function. Second International Workshop
on Insulin-like Growth Factor Binding Proteins, August, 1992, Opio,
France.
45. Gargosky SE, Pham HM, Wilson DM, Giudice LC, Rosenfeld RG.
Comparative Use of Immunological and Ligand Blotting of IGFBPs in Serum
and Other Biological Fluids. The 6th Meeting of the Research Society for
the Growth Disturbance in Children, Milan, September, 1992.
46. Giudice LC, Dsupin BA, Vu TH, Jin IH, Hoffman AR: Insulin-like
Growth Factor-I (IGF-I), IGF-II, and IGF Binding Protein (IGFBP) Gene
Expression in Human Uterine Leiomyomata. American Fertility Society, New
Orleans, November, 1992.
47. Irwin JC, Dsupin BA, Giudice LC: Insulin-like Growth Factor Binding
Protein-3 Secretion by Cultured Human Endometrial Stromal Cells Is
Increased by Transforming Growth Factor- (TGF-). American Fertility
Society, New Orleans, November, 1992.
48. Giudice LC, Dsupin BA, Navre M. Differential Expression of Type IV
(72 kDa) Collagenase mRNA in Human Endometrium During the Menstrual
Cycle in Early Pregnancy Decidua and Term Placenta. American Fertility
Society, New Orleans, November, 1992.
49. Giudice LC, Irwin JC, Dsupin BA, Fielder PJ. Insulin-like Growth
Factor (IGF) Regulation of IGF Binding Protein (IGFBP) Production by
Human Leiomyomata Smooth Muscle Cells Is Dependent On Protein Synthesis
and On Induction of an IGFBP-4 Specific Protease. Society for
Gynecologic Investigation, Toronto, March, 1993.
50. Giudice LC, Dsupin BA, Jin IH, Vu TH, Hoffman AR. Insulin-like
Growth Factor (IGF), IGF Binding Protein, and IGF Receptor Gene
Expression in Human Oviductal Fimbria Throughout the Menstrual Cycle.
Society for Gynecologic Investigation, Toronto, March, 1993.
51. Gargosky SE, Giudice LC, Rosenfeld RG, Fazleabas A. The Different
Molecular Forms of Insulin-like Growth Factor Binding Protein-3 in
Baboon (Papio Anubis) Maternal Serum. Society for the Study of
Reproduction, Colorado Springs, Colo, July, 1993.
52. Madsen BL, Giudice LC, Donaldson S. Radiation Related Premature
Menopause - A Misconception. Society for Radiotherapists, Orlando, Fla,
October, 1993.
53. Giudice LC, Dsupin BA, Irwin JC: Insulin-like Growth Factor (IGF),
IGF Binding Protein (IGFBP), and IGFBP Protease Activity in Human
Peritoneal Fluid. Endocrine Society, Las Vegas, Nevada, June 9-12, 1993.
54. Dsupin BA, Milki AA, Giudice LC: Follicular Fluid (FF) Content of
Insulin-like Growth Factors (IGFs) and IGF Binding Protein-3 (IGFBP-3)
in Luteinized Unruptured Follicle Syndrome (LUFS). Endocrine Society,
Las Vegas, Nevada, June 9-12, 1993.
55. Gargosky SE, Dsupin BA, Giudice LC: Insulin-like Growth Factor
Binding Protein-3 (IGFBP-3) Protease in Human Peritoneal Fluid: Its
Potential Relevance to Endometriosis. The American Fertility Society,
Montreal, October 9-14, 1993.
56. Giudice LC, Fielder PF, Irwin JC: Endometrial Stromal Cell
Insulin-like Growth Factor Binding Protein-4 Regulation is Mediated by
an IGFBP-4 Specific Protease. The American Fertility Society, Montreal,
October 9-14, 1993.
57. Irwin JC, de las Fuentes L, Dsupin BA, Giudice LC: Growth Factors
and Decidualization In Vitro. Second Conference on The Endometrium,
September 20-22, 1993, Bologna, Italy.
58. Gargosky SE, Giudice LC, Rosenfeld RG, Fazleabas AT: Detection of
Alternative Molecular Forms of IGFBP-3 in the Absence of Protease
Activity in the Pregnant Baboon (Papio Anubis). Third International
Symposium on Insulin-like Growth Factors, Sydney, February 6-10, 1994.
59. Chandrasekher YA, Giudice LC: IGF-I and IGF-II Regulate IGFBP-4
Levels in Explant Cultures of Human Ovarian Stroma. Third International
Symposium on Insulin-like Growth Factors, Sydney, February 6-10, 1994.
60. Yap OWS, Chandrasekher YA, Giudice LC: Growth Factor Regulation of
IGFBP Secretion by Cultured Human Granulosa-luteal Cells. Third
International Symposium on Insulin-like Growth Factors, Sydney, February
6-10, 1994.
61. Pannier EM, Irwin JC, Giudice LC: Differential Expression of IGFBPs
and Regulation of IGFBP-4 in Human Uterine Myometrium, Myoma, and
Leiomyosarcoma. Third International Symposium on Insulin-like Growth
Factors, Sydney, February 6-10, 1994.
62. Nonoshita L, Dsupin BA, Chard T, Wathen NC, Giudice LC: IGFs and
IGFBPs in Embryonic Cavities Early Human Pregnancy: Their Potential
Relevance to Maternal-Fetal Interactions. Third International Symposium
on Insulin-like Growth Factors, Sydney, February 6-10, 1994.
63. Giudice LC, Irwin JC, Dsupin BA, de Las Fuentes L: Insulin-like
Growth Factors, Their Binding Proteins, and Binding Protein Proteases in
Human Uterine Cellular Growth and Differentiation. Third International
Symposium on Insulin-like Growth Factors, Sydney, February 6-10, 1994.
64. Seifer DB, Giudice LC, Dsupin BA, Haning RV, Frishman GN, Burger HG:
Determination of the Proliferative Index of Luteinized Granulosa Cells
and Follicular IGF-I, IGF-II, and Inhibin Concentrations as a Function
of Day 3 Serum FSH. Society for Gynecologic Investigation, Chicago,
March 22-25, 1994.
65. Seifer DB, Giudice LC, Penzias AS, Dsupin BA, Haning RV Jr.
Follicular Fluid Concentrations of IGF-I Vary Between Women Receiving
hMG plus GnRH-a and hMG Only for Ovulation Induction Regimens. Society
for Gynecologic Investigation, Chicago, March 22-25, 1994.
66. Irwin JC, Dsupin BA, Giudice LC: Insulin-like Growth Factor (IGF)
Regulation of IGF Binding Protein-1 (IGFBP-1) Secretion by In Vitro
Decidualized Human Endometrial Stromal Cells. Society for Gynecologic
Investigation, Chicago, March 22-25, 1994.
67. Chandrasekher YA, Giudice LC: Characterization of an Insulin-like
Growth Factor Binding Protein-4 (IGFBP-4) Protease in Estrogenic
Follicular. Society for Gynecologic Investigation, Chicago, March 22-25,
1994.
68. Taskin O, Dsupin BA, Wiehle RW, Giudice LC: Insulin-like Growth
Factor Binding Proteins in Peritoneal Fluid from Women with
Endometriosis. Society for Gynecologic Investigation, Chicago, March
22-25, 1994.
69. Zhou J, Dsupin BA, Giudice LC, Bondy C. Insulin-like Growth Factor
(IGF), IGF Binding Protein, and IGF Receptor Gene Expression in Human
Endometrium. Society for Gynecologic Investigation, Chicago, March
22-25, 1994.
70. Lee KO, Oh Y, Giudice LC, Cohen P, Peehl DM, Rosenfeld RG.
Identification of Insulin-like Growth Factor Binding Protein (IGFBP)-3
Fragments, and IGFBP-5 Proteolytic Activity in Human Seminal Plasma: A
Comparison of Normal and Vasectomized Patients. The Endocrine Society,
Anaheim, June 15-18, 1994.
71. Westphal LM, Vu TH, Pearson S, Giudice LC, Hoffman AR. Insulin-like
Growth Factor II Gene Expression in Uterine Leiomyomata. The Endocrine
Society, Anaheim, June 15-18, 1994.
72. Zhou J, Dsupin BA, Giudice LC, Bondy C. Cyclic Changes in
Insulin-like Growth Factor System Gene Expression in Human Endometrium.
The Endocrine Society, Anaheim, June 15-18, 1994.
73. Snabes MC, Dsupin BA, Young RL, Giudice LC. Estradiol Replacement
Therapy (ERT) Inhibits Insulin-like Growth Factor-I, but Not IGF Binding
Protein-3 in Serum of Postmenopausal Women. The Endocrine Society,
Anaheim, June 15-18, 1994.
74. Chandresekher YA, Giudice LC, Bai C, Liu H-L, Rosenwaks Z, Poretsky
L. Insulin and Insulin-like Growth Factor -I (IGF-I) Inhibit IGF Binding
Protein-1 (IGFBP-1) Production by Human Granulosa-Luteal Cells (hGCs).
American Fertility Society, November 5-10, 1994, San Antonio, TX.
75. Giudice LC, Chandrasekher YA. Proteolysis of IGFBP-4 as a Mechanism
to Increase Intrafollicular IGFs. Third Sapporo International Symposium
on Ovarian Function, Sapporo, Japan, September 2-3, 1994.
76. Yap OWS, van Dessel T, Fauser BJCM, Giudice LC: Similar IGF-I and
IGF-II Levels, but Different IGF Binding Protein Profiles, in Androgen-
and Estrogen-dominant Follicles Suggest Endo/Autocrine IGF Action and
Regulation in Human Ovary. Society for Gynecologic Investigation,
Chicago, March 22-25, 1995, Abstract No. P-337.
77. Irwin JC, Dsupin BA, Giudice LC: IGF Binding Protein-1 Inhibits
Cytotrophoblast Attachment to Fibronectin In Vitro. Society for
Gynecologic Investigation, Chicago, March 22-25, 1995, Abstract No.
P-288.
78. Klein NA, Battaglia DE, Miller PB, Giudice LC, Soules MR. The
Ovarian Follicular Fluid Environment in Reproductive Aging: Changes in
Hormones and Growth Factors. Society for Gynecologic Investigation,
Chicago, March 22-25, 1995, Abstract No. 0-10.
79. Giudice LC, van Dessel T, Cataldo NA, Chandrasekher YA, Yap OWS,
Faessen G, Fauser BCJM. IGFs, IGF Binding Proteins (IGFBPs), and IGFBP
Proteases in Estrogen- and Androgen-dominant Follicles in Human Ovary:
Relevance to PCOS. Polycystic Ovarian Syndrome, Serono Symposium,
Boston, May 25-26, 1995.
80. Bang P, Giudice LC, Fielder PJ. Human Pregnancy Serum Contains Two
Distinct IGFBP-3 Protease Activities: Role of the Plasminogen/Plasmin
System as IGFBP Proteases. The Endocrine Society, Washington DC, June
14-17, 1995.
81. Chandrasekher YA, Clark CR, Faessen GH, Giudice LC: Insulin-like
Growth Factor Binding Protein Profile in Theca Explant Cultures from
Normal Human Ovaries. The Endocrine Society, Washington DC, June 14-17,
1995.
82. Irwin JC, Dsupin BA, Giudice LC: Insulin-like Growth Factor Binding
Protein-1 (IGFBP-1) Modulates Interaction of Isolated Placental
Cytotrophoblasts with Fibronectin and Endometrial Stromal Cell Cultures.
The Endocrine Society, Washington DC, June 14-17, 1995.
83. Poretsky L, Chandrasekher YA, Bai C, Liu HC, Rosenwaks Z, Siddle K,
Giudice LC: Insulin and IGF-I Inhibit IGF Binding Protein-1 (IGFBP-1)
Production in Human Granulosa Cells Via Their Respective Receptors. The
Endocrine Society, Washington DC, June, 1995.
84. van Dessel HJ, Faessen GH, Chandrasekher YA, Fauser BC, Giudice LC:
Serum Insulin-like Growth Factor (IGF)-I and IGF Binding Protein (IGFBP)
Levels Throughout the Menstrual Cycle. The Endocrine Society, Washington
DC, June 14-17, 1995.
85. Yap OWS, Chandrasekher YA, van Dessel HJHM, Fauser BJCM, Giudice LC:
Similar Insulin-like Growth Factor Binding Protein Profiles in
Androgen-dominant Follicular Fluid from Normal, Polycystic Ovary
Syndrome, and Androgen-Treated Female-to Male Transsexual Human Ovaries.
The Society for the Study of Reproduction, Sacramento, CA, July 9-12,
1995.
86. Chandrasekher YA, Clark CR, Faessen GH, Giudice LC: Role of
Insulin-like Growth Factor Binding Protein-4 (IGFBP-4) and IGFBP-4
Protease in Human Granulosa Cell Function. The Society for the Study of
Reproduction, Sacramento, CA, July 9-12, 1995.
87. Irwin JC, Dsupin BA, Giudice LC: Modulation of Cytotrophoblast
Interaction with Fibronectin and Endometrial Stromal Cell Cultures by
Insulin-like Growth Factor Binding Protein-1 (IGFBP-1). The Society for
the Study of Reproduction, Sacramento, CA, July 9-12, 1995.
88. van Dessel HJHM, Yap OWS, Chandrasekher YA, Faessen G, Fauser BJCM,
Giudice LC: Insulin-like Growth Factor (IGF)-I, IGF-II, and IGF Binding
Proteins-1 and -3 in Individual Follicles Throughout the Follicular
Phase of the Normal Menstrual Cycle. The American Society for
Reproductive Medicine, Seattle, October 7-12, 1995.
89. Giudice LC: Biology of the Endometrium: Growth Factors and Cytokines
Important in Endometrial Cyclic Development and Implantation. Symposium
on Long-term Effects of Estrogen Deprivation, Aspen, Colorado, July
8-11, 1995.
90. Giudice LC. Growth Factors in Endometrial Function. Alza
Risk/Benefit Consensus Conference on Hormonal Replacement Therapy, Napa,
November 5-7, 1995.
91. Irwin JC, Martina NA, Giudice LC: Insulin-like Growth Factor Binding
Protein-1 Binds to Cytotrophoblast 51 Integrin and Inhibits
Cytotrophoblast Invasion into Decidual Multilayers. Society for
Gynecologic Investigation, Philadelphia, March 20-23, 1996.
92. Giudice LC, Martina NA, Chitkara U, Druzin MD. Insulin-like Growth
Factor Binding Protein-1 is Elevated in Serum and at the Maternal:Fetal
Interface in Patients with Severe Pre-eclampsia, a Disorder of Shallow
Implantation. Society for Gynecologic Investigation, Philadelphia, March
20-23, 1996.
93. Kim E, Martina NA, Giudice LC: Nonphospho IGFBP-1 is the Primary
Form of IGFBP-1 in Follicle Fluid from IVF Patients. Society for
Gynecologic Investigation, Philadelphia, March 20-23, 1996.
94. Giudice LC. The importance of growth factors in human endometrium
during the reproductive cycle. Wyeth Ayerst Symposium on Endometrial
Markers in Health and Disease. Philadelphia, May 31, 1996.
95. Giudice, LC, Irwin JC, Martina NA. Does Mother Have a Say in
Implantation? National Institutes of Health Conference on Human Uterine
Receptivity for Blastocyst Implantation, Bethesda, June 10-11, 1996.
96. Giudice LC. Growth Factors and Ovarian Function. 10th International
Congress of Endocrinology, San Francisco, June 12-15, 1996.
97. Giudice LC, Martina NA, Crystal RA, Druzin MD. IGFBP-1 at the
Maternal:Fetal Interface and Circulating IGF-I, IGF-II, and IGFBP-1 in
Severe Pre-eclampsia. 10th International Congress of Endocrinology, San
Francisco, June 12-15, 1996.
98. Clark CR, Kim E, Chandrasekher YA, Martina NA, Poretsky L, Giudice
LC. Two Distinct Isoforms of IGFBP-1 Are Found in Luteinizing Granulosa
Cell Conditioned Media from IVF Patients. 10th International Congress of
Endocrinology, San Francisco, June 12-15, 1996.
99. Chandrasekher YA, Evans ACO, Giudice LC, Fortune JE. Ovarian
Follicular Dominance is Associated with the Presence of Insulin-like
Growth Factor Binding Protein-4 (IGFBP-4) Protease Activity in Cattle.
Society for the Study of Reproduction, July 27-29, 1996, London,
Ontario, Abstract 519, p186.
100. Martina NA, Kim E, Kim E, Chard T, Giudice LC. Nonphospho
Insulin-like Growth Factor Binding Protein-1 is the Primary form of
IGFBP-1 in Amniotic Fluid (AF), Coelomic Fluid (CF), and Maternal Serum
(MS) During Early Gestation. American Society for Reproductive Medicine,
Boston, November 2-6, 1996, Abstract O-0161
101. Martina NA, Giudice LC. Maternal Decidua is Likely the Major Source
of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) in Maternal
Serum, Amniotic Fluid, and Coelomic Fluid in Early Pregnancy. American
Society for Reproductive Medicine, Boston, November 2-6, 1996, Abstract
O-0160
102. Mark SP, Martina NA, Irwin JC, Giudice LC. Cytokine Regulation of
Insulin-like Growth Factor Binding Protein-1 Production in Decidualized
Endometrial Stromal Cells. American Society for Reproductive Medicine,
Boston, November 2-6 1996, Abstract O-007.
103. van Dessel HJ, Chandrasekher YA, Faessen G, Lee PD, Fauser BC,
Giudice LC. Elevated Serum Levels of Free Insulin-like Growth Factor
(IGF-I) in Polycystic Ovary Syndrome. American Society for Reproductive
Medicine, Boston, November 2-6, 1996, Abstract P-0217
104. Swiersz LM, Irwin JC, Giudice LC: The Effect of
2,3,7,8-tetrachlorodibenzo-p-dioxin on Human Endometrial Stromal Cells
In Vitro. Vth World Congress on Endometriosis. Yokohama, October 21-24,
1996.
105. Ulaner GA, Giudice LC. Tissue-specific and Developmentally
Regulated Expression of Telomerase in the Human Fetus. American
Federation for Medical Research, Carmel, February 5-8, 1997.
106. Irwin JC, Giudice LC: Anti-IGFBP-1 stimulates Human Cytotrophoblast
Invasion into Decidualized Endometrial Stromal Cell Multilayers. Soc
Gynecol Invest 1997 Prize Paper.
107. Yuan W, Chandrasekher YA, Morton-Bours E, Giudice LC. Apoptosis
Analysis in Human Ovarian Follicles. Soc Gynecol Invest 1997, poster
presentation.
108. Yuan W, Chandrasekher YA, Morton-Bours E, Giudice LC. Gene
Expression for Insulin-like Growth Factor (IGF)-I, IGF-II, and
Steroidogenic Enzyme Expression in Human Ovaries. Soc Gynecol Invest
1997, poster presentation.
109. Ulaner GA, Giudice LC: Telomerase Activity in the Human Fetus:
Evidence for Gestational Age and Tissue-Specific Expression. Soc Gynecol
Invest 1997, oral presentation.
110. Springer EA, MJ Morrell, Giudice LC. Seizure Distribution in Women
with Localization Related Epilepsy (LRE) of Temporal and Extratemporal
Lobe Origin. American Epilepsy Society, 1997.
111. Morrell MJ, Springer EA, Giudice LC. Reproductive Function in Women
with Epilepsy on Inducing and Non-inducing Antiepileptic Drugs. American
Epilepsy Society.
112. Yuan W, Giudice LC: Apoptosis in Human Follicles and Corpora Lutea.
97-Symposium for Young Chinese Reproductive Biologists, Beijing, China,
October 14-18, 1997.
113. Ulaner GA, Vu T, Hoffman AR, Giudice LC. In Situ Detection of
Telomerase Activity in Cryosectioned Cells Pellets. Am Red Med Res Soc,
Western Regional Meetings, February 4-7, 1998, Carmel, CA.
114. Irwin JC, Suen L-F, Giudice LC. Proteolysis of Insulin-like Growth
Factor Binding Protein-3 (IGFBP-3) by Human Placental Trophoblasts: a
Potential Source for the Pregnancy-Associated Serum IGFBP-3 Protease. J
Soc Gynecol Invest 1998;5:49A, Abstract # 42.
115. Kitazawa M, Suen L-F, Irwin JC, Wilson L, Oh Y-M, Rosenfeld RG,
Giudice LC. Human Decidua and Decidualized Endometrial Stromal Cells
(ESC), but not Trophoblast, Express Insulin-like Growth Factor Binding
Protein-related Protein-1 (IGFBP-rP-1) Which is Regulated by IGF-II. J
Soc Gynecol Invest 1998;5:113A, Abstract # 304.
116. Tazuke SI, Mazure N, Motani A, Powell DR, Giaccia A, Giudice LC.
Hypoxia Response Element (HRE) in the Insulin-like Growth Factor Binding
Protein-1 (IGFBP-1) Gene is Functional: Potential Relevance to In Utero
Hypoxia. J Soc Gynecol Invest 1998;5:65A, Abstract # 105.
117. Tazuke SI, Mazure N, Motani A, Powell DR, Giaccia A, Giudice LC.
Hypoxia Regulation of Insulin-like Growth Factor Binding Protein-1
(IGFBP-1): Potential Mechanisms for Growth Regulation of the IUGR Fetus.
J Soc Gynecol Invest 1998;5:160A, Abstract # 497.
118. Sugawara J, Tazuke SI, Mazure N, Powell DR, Giaccia A, Giudice LC.
Regulation of Insulin-like Growth Factor Binding Protein-1 Expression by
Hypoxia and Insulin. J Soc Gynecol Invest 1998;5:160A, Abstract # 498.
119. Giudice LC. Practical Aspects of Ovulation Induction. Indian
Endocrine Society, ESICON 97, December 17-19, 1997, p 93.
120. Ulaner GA, Vu T, Hoffman AR, Giudice LC. In situ detection of
telomerase activity in Cryosectioned cell pellets. Western Regional
Meetings, February 4-7, 1998, Carmel, CA.
121. Irwin JC, Suen L-F, Giudice LC. Proteolysis of Insulin-like Growth
Factor Binding Protein-3 (IGFBP-3) by Human Placental Trophoblasts: A
Potential Source for the Pregnancy-Associated Serum IGFBP-3 Protease.
NIH Specialized Center in Reproductive Research, Reproductive Research
Day, Stanford University, January 24, 1998.
122. Tazuke SI, Mazure N, Suen L-F, Powell DR, Giaccia A, Giudice LC.
Hypoxia Regulation of Insulin-like Growth Factor Binding Protein-1
(IGFBP-1): Potential Mechanisms for Growth Regulation of the IUGR Fetus.
NIH Specialized Center in Reproductive Research, Reproductive Research
Day, Stanford University, January 24, 1998.
123. Popovici R, Motani A, Irwin JC, Fisher SJ, Giudice LC. IGF Binding
Protein-1 is induced in human decidualized endometrial stromal cells in
response to the chemical hypoxicant, CoCl2. International Symposium on
Reproductive Medicine: State of the Art of Human Implantation, Basic and
Clinical Aspects. Madrid, May 18-19, 1998.
124. Irwin JC, Giudice LC. Leu27 IGF-II, an Analogue Which
Preferentially Binds to the Type 2 IGF Receptor) Inhibits IGFBP-1
Production by Decidualized Human Endometrial Stromal Cells. Endocrine
Society, New Orleans, June 21-24, 1998
125. Sugawara J, Tazuke SI, Suen LF, Powell DR, Giaccia AJ, Giudice LC.
Hypoxia and cAMP Coordinately Regulate Insulin-like Growth Factor
Binding Protein-1 (IGFBP-1) in HepG2 Cells. Endocrine Society, New
Orleans, June 21-24, 1998.
126. Tazuke SI, Mazure N, Powell DR, Giaccia A, Giudice LC. Functional
Study of Hypoxia Response Element (HRE) in the IGFBP-1 Gene: Potential
Relevance to in utero Hypoxia. Endocrine Society, New Orleans, June
21-24, 1998.
127. Tazuke SI, Mazure N, Suen LF, Powell DR, Giaccia A, Giudice LC. In
Vitro Induction of IGFBP-1 by Hypoxia in HepG2 Cells: Potential
Mechanism for Growth Regulation of the Hypoxic Fetus. Endocrine Society,
New Orleans, June 21-24, 1998.
128. Irwin JC, Cheng B-H, Giudice LC. Human peritoneal fluid contains a
specific insulin-like growth factor binding protein-3 (IGFBP-3) protease
which is distinct from plasmin. International Fertility Federation
Societies (IFFS)/American Society for Reproductive Medicine (ASRM), San
Francisco, Oct 9-12, 1998; ), O-171; Suppl 1;70:No 3, pS64.
129. Morton-Bours E, Batey D, Suen LF, Yuan W, Giudice LC. Regulation of
Insulin-like Growth Factor-II Expression in Human Granulosa-Luteal Cells
by human Chorionic Gonadotropin (hCG) and Epidermal Growth Factor (EGF).
International Fertility Federation Societies (IFFS)/American Society for
Reproductive Medicine (ASRM), San Francisco, Oct 9-12, 1998; ), P-873;
Suppl 1;70:No 3, p S399.
130. Menardi TRA, Dasig D, Milki AA, Lamb EJ, Behr B, Giudice LC. A
follow-up Study of Assisted Reproductive Technology (ART) Pregnancies at
Stanford University. International Fertility Federation Societies
(IFFS)/American Society for Reproductive Medicine (ASRM), San Francisco,
Oct 9-12, 1998 ), P-879; Suppl 1;70:No 3, p S1138
131. Fisch JD, Milki AA, Giudice LC, Moore D, Gebhardt J, Branch M,
Dasig D, Behr B. Preliminary Report on the IVF-ET Pregnancy Rate in
Patients under 40 with Sibling Embryos Cryopreserved as Blastocysts.
International Fertility Federation Societies (IFFS)/ American Society
for Reproductive Medicine (ASRM), San Francisco, Oct 9-12, 1998. ),
O-309; Suppl 1;70:No 3, pS115.
132. Behr B, Milki AA, Giudice LC, Moore D, Gebhardt J, Branch M. High
yield blastocyst culture and transfer: a new approach using P1 and
blastocyst medium in a reduced O2 environment. International Fertility
Federation Societies (IFFS)/ American Society for Reproductive Medicine
(ASRM), San Francisco, Oct 9-12, 1998 (Nominated Prize Paper), O-262;
Suppl 1;70:No 3, pS98.
133. Giudice LC. Growth factors and polycystic ovarian syndrome.
International Symposium on Polycystic Ovary Syndrome: Update, Athens,
November 18-20, 1998,
134. Sugawara J, Tazuke SI, Suen L-F, Kaper F, Powell DR, Giaccia AJ,
Giudice LC. Hypoxia and cAMP increase stability of insulin-like growth
factor binding protein-1 (IGFBP-1) mRNA in HepG2 cells. J Soc Gynecol
Invest 1999;6:1372A, Abstract No. 354.
135. Popovici RM, Irwin JC, Giaccia AJ, Giudice LC. Hypoxia and cAMP are
Potent Stimuli of Vascular Endothelial Growth Factor (VEGF) in
Endometrial Stromal Cells. J Soc Gynecol Invest 1999;6:72A, Abstract No.
107.
136. Irwin JC, Suen L-F, Giudice LC. Insulin-like Growth Factor-II
(IGF-II) Inhibits TIMP-3 production by Decidualized Human Endometrial
Stromal Cells: Possible Role in Trophoblast Invasiveness in Human
Implantation. J Soc Gynecol Invest 1999;6:82A, Abstract No. 145.
137. Popovici RM, Sugawara J, Irwin JC, Giaccia AJ, Giudice LC: Hypoxia
and cAMP synergistically stimulate insulin-like growth factor-II
(IGF-II) in HepG2 cells. J Soc Gynecol Invest 1999;6:118A, Abstract No.
280.
138. Ionel OA, Irwin JC, Popovici RM, Giaccia AJ, Giudice LC: Hypoxia
regulates the expression of IGFBP-3 in human endometrial carcinoma and
breast carcinoma. J Soc Gynecol Invest 1999;6:167A, Abstract No. 471.
139. Irwin JC, Suen L-F, Giudice LC. Insulin-like growth factor-II
(IGF-II) inhibits endometrial stromal cell tissue inhibitor of
metalloproteinase-3 (TIMP-3) and IGF binding protein-1 (IGFBP-1) mRNA:
Potential relevance to paracrine interactions at the
decidual:trophoblast interface. J Soc Gynecol Invest 1999;6:217A,
Abstract No. 667.
140. Giudice LC. The IGF Family at the Maternal:Fetal Interface in Human
Genstation”, Symposium Lecture, 5th International Symposium on
Insulin-like Growth Factors, Brighton, UK, October 31-November 4, 1999.
141. Popovici R, Lu M, Giaccia A, Giudice LC. Hypoxia and cAMP
regulation of IGFBP-1 in human fetal hepatocytes in primary culture:
molecular mechanisms underlying elevated IGFBP-1 in growth restricted
babies in utero. 5th International Symposium on Insulin-like Growth
Factors, Brighton, UK, October 31-November 4, 1999.
142. Irwin JC, Suen L-F, Giudice LC. Proteolysis of Insulin-like Growth
Factor Binding Protein-3 (IGFBP-3) by Human Placental Trophoblasts: A
Potential Source for the Pregnancy-Associated Serum IGFBP-3 Protease.
5th International Symposium on Insulin-like Growth Factors, Brighton,
UK, October 31-November 4, 1999.
143. Ishikawa K, Fukasawa I, Watanabe H, Giudice LC, Inaba N.
Differential expression of MMP-2 and -9 in human endometrium and the
influence of GnRH agonist: an immunohistochemical study. The 7th Ann Mtg
Japan Placenta Study Group. November 2-6, 1999.
144. Popovici RM, Lu M, Ishikawa K, Giaccia AC, Giudice LC. Hypoxia and
insulin regulation of IGFBP-1 in human fetal hepatocytes in primary
culture: mechanisms underlying elevated IGFBP-1 levels in fetal growth
restriction. Soc Gynecol Invest Annual Meeting March, 2000.
145. Suh D-S, Giaccia AJ, Giudice LC. Hypoxia stabilizes mRNA of human
insulin-like growth factor binding protein-1 in HepG2 human hepatoma
cells. Soc Gynecol Invest Annual Meeting March, 2000.
146. Conover CA, Oxvig C, Overgaard MT, Christiansen M, Giudice LC. The
insulin-like growth factor binding protein-4 protease in human ovarian
follicular fluid is pregnancy associated plasma protein-A. Soc Gynecol
Invest Annual Meeting March, 2000.
147. Zamudio S, Broad E, Niccoli S, Bhatia S, Tissot Van Patot M, Moore
LG, Faessen G, Giudice LC. IGFBP-1 and IGF-I in high vs. moderate
altitude pregnancy. Soc Gynecol Invest Annual Meeting March, 2000.
148. Popovici RM, Kao L-C, Giudice LC. Discovery of New Inducible Genes
in In Vitro Decidualized Human Endometrial Stromal Cells Using
Microarray Technology. The Endocrine Society Annual Meeting, June, 2000.
149. Popovici RM, Kao L-C, Giudice LC. Gene Discovery in Human
Endometrium. Oxford-Kobe Symposium on Cellular and Molecular Biology of
the Endometrium, Kobe, October 2-6, 2000.
150. Bhatia S, Gaessen GH, Carland G, Balise RR, Gargosky SE, Druzin MD,
Wilson DM, Giudice LC. A Longitudinal Analysis of Maternal Serum IGF-I
and IGFBP-1 in Human Pregnancies with Small for Gestational Age Fetuses.
IGFBP-2000, Terrigal, Australia, October 27-29, 2000.
151. Bhatia S, Faessen GH, Carland G, Balise R, Gargosky SE, Druzin M,
Wilson DM, Giudice LC. Women Who Develop Mild Pre-eclampsia Have
Decreased Serum Nonphosphorylated IGFBP-1 in the First and Second
Trimesters and Abnormal Insulin Response to Glucose Challenge in the
Third Trimester: A Longitudinal Study. IGFBP-2000, Terrigal, Australia,
October 27-29, 2000.
152. Giudice LC, Oxvig C, Overgaard M, Christiansen MT, Conover C. “What
is Pregnancy-Associated Plasma Protein-A Doing in Human Ovary?”
IGFBP-2000, Terrigal, Australia, October 27-29, 2000.
153. Giudice LC, Oxvig C, Overgaard MT, Christiansen M, Faessen G,
Conover C. PAPP-A is a marker of follicle selection in human ovary. J
Soc Gynecol Invest 2001;8:abstract # 761.
154. Sun I Irwin JC, Giudice LC. Mutation of the RGD sequence
demonstrates IGFBP-1 binding to v3 and 51 integrins in human
cytotrophoblasts (CTB) and raises question of this sequence in IGFBP-1
regulation of CTB invasion into decidua. J Soc Gynecol Invest
2001;8:Abstract 227.
155. Swiersz LM, Zundel W, Maecker HL, Giudice LC, Giaccia AJ. Loss of
PTEN facilitates estrogen receptor activation J Soc Gynecol Invest
2001;8:Abstract 69.
156. Giudice LC, Kao LC, Yang J-P, Taylor RN, Osteen K, Lessey BD.
Global gene expression profiling of human endometrium from women with
endometriosis using Genechip microarray technology. NIH Workshop on
Endometriosis: Emerging Research and Intervention Strategies. April
9-10, 2001, Bethesda, MD.
157. Giudice LC, Cataldo NA. The Insulin-like growth factor system
Normal Human Ovaries and in Polycystic Ovarian Syndrome. Soc Study of
Reprod 2001, Minisymposium.
158. Giudice LC, Conover CA, Faessen GH, Suen L-F, , Christiansen M,
Overgaard MT, Oxvig C. The insulin-like growth factor binding protein-4
proteinase secreted by human placental trophoblasts and endometrial
stromal cells is pregnancy-associated plasma protein-A (PAPP-A).
Abstract accepted Endo Soc 2001, OR5-2.
159. Giudice LC, Conover CA, Faessen GH, Popovici RM, Sun I, ,
Christiansen M, Overgaard MT, Oxvig C. Differential regulation of PAPP-A
and its inhibitor in human trophoblasts and endometrial stromal cells by
insulin-like peptides suggests paracrine interactions during human
implantation. Endo Soc Annual Meeting, 2001, P3-26.
160. Telles TL, Kao LC, Suh D, Giudice LC. Cyclooxygenase-1 (COX-1) and
COX-2 expression in human endometrium. Endo Soc Annual Meeting, 2001,
P1-7.
161. Kao LC, Yang J, Lessey B, Giudice LC. Gene expression profiles in
human endometrium during the window of implantation from subjects with
endometriosis, using genechip microarray. Endo Soc Annual Meeting, 2001,
P1-8.
162. Kao LC, Giudice LC. Human endometrium gene profiles during the
window of implantation by Genechip microarray. Endo Soc Annual Meeting,
2001, P1-10.
163. Vergaeghe JO, Giudice LC. IGFBP-1 in umbilical artery and vein of
term fetuses with signs suggestive of distress during labor. Endo Soc
Annual Meeting, 2001, P1-161.
164. Giudice LC. Gene discovery in human endometrium. Abstract Japan
Society for Fertility and Sterility Annual Meeting, 2001.
165. Kao L-C, Yang J, Lessey BD, Giudice LC. Microarray expression
profiling reveals candidate genes for human uterine receptivity.
Abstract, American Society for Reproductive Medicine Annual Meeting,
October 2001, O-159.
166. Kao L-C, Tulac S, Imani B, Yang JP, Lessey BD, Giudice LC.
Expression profile comparisons in eutopic endometrium between women with
and without endometriosis during the window of implantation. Abstract,
VIII World Congress on Endometriosis, February, 2002, P-3.
167. Tulac S, Kao L-C, Giudice, LC. Unveiling a novel signaling system,
the Wnt pathway, in human endometrium. Society for Gynecologic
Investigation Annual Meeting, J Soc Gynecol Invest 2002; 9:Abstract #
610.
168. Tierney E, Giudice LC. Role of activin A as mediator of in vitro
endometrial stromal cell decidualization via the cAMP pathway. Abstract
#42, Nineteenth Annual Stanford Medical Student Research Symposium,
Stanford University School of Medicine, May 3, 2002.
169. Giudice LC. Gene Discovery in Human Endometrium. Endocrine Society
Symposium Speaker, June 2002.
170. Tulac S, Kao L-C, Giudice LC. Detection of wnt signaling pathway in
normal human endometrium. Abstract, The Endocrine Society Annual
Meeting, June 2002, P1-491.
171. Tierney EP, Tulac S, Huang J, Kao L-C, Giudice LC. Sequential
induction of gene expression during human endometrial stromal cell
decidualization using microarray expression profile analysis. Abstract,
The Endocrine Society Annual Meeting, June 2002, P3-192.
172. Huang STJ, Vo KCT, Giaccia AJ, Giudice LC. Fetal genes regulated by
hypoxia during development. Abstract, The Endocrine Society Annual
Meeting, June 2002, P3-26.
173. Laursen LS, Overgaard MT, Nielsen CG, Conover CA, Giudice LC, Oxvig
C. Substrate specificity of PAPP-A assessed by mutagenesis and analysis
of synthetic peptides. 1st Joint Symposium GH-IGF 2002 Meeting, October,
2002.
174. Weyer K, Laursen LS, Overgaard MT, Giudice LC, Oxvig C. Cell
surface targeting of PAPP-A proteolytic activity. 1st Joint Symposium
GH-IGF 2002 Meeting, October, 2002.
175. Lobo SC, Huang J, Tulac S, Giudice LC. The immune environment in
human endometrium during the window of implantation. Oral presentation
American Society for Reproductive Medicine Annual Meeting, Seattle,
October, 2002.
176. Lathi RB, Tulac S, Lobo S, Huang J, Giudice LC. Changes in cytokine
expression in peripheral leukocytes, detected by microarray analysis, in
the secretory vs. proliferative phase of the menstrual cycle. Oral
presentation. American Society for Reproductive Medicine Annual Meeting,
Seattle, October, 2002.
177. Germeyer A, Tulac S, Nayak N, Giudice LC, Kao LC. Semaphorin E and
its receptors Nueropilin 1 & 2 in human endometrium. Oral presentation.
American Society for Reproductive Medicine Annual Meeting, Seattle,
October, 2002.
178. Cataldo NA, Abbasi F, McLaughlin TL, Techner PY, Reaven GM, Giudice
LC. Rosiglitazone in sinulin-resistant women with polycystic ovary
syndrome (PCOS): effects on ovarian function and metabolism. Oral
presentation. American Society for Reproductive Medicine Annual Meeting,
Seattle, October, 2002.
179. Reproductive Medicine Network. The Endometrial biopsy as a
diagnostic tool in the evaluation of the infertile patient. Oral
presentation. American Society for Reproductive Medicine Annual Meeting,
Seattle, October, 2002.
180. Milki AA, Jun SH, Hinckley MD, Behr B, Giudice LC, Westphal LM.
Incidence of monozygotic twinning with blastocyst transfer compared to
cleavage stage transfer. Oral presentation. American Society for
Reproductive Medicine Annual Meeting, Seattle, October, 2002.
181. Milki AA, Jun SH, Hinckley MD, Westphal LM, Behr B, Giudice LC.
Does blastocyst transfer alter the sex ratio? One program’s experience
and review of the literature. Oral presentation. American Society for
Reproductive Medicine Annual Meeting, Seattle, October, 2002.
182. Groll JM, Vendrov AE, Marshall JC, Evans WS, Giudice LC, Lessey BA.
Endometrial gene profiling in women with polycystic ovary syndrome
compared to normal women. Society for Gynecologic Investigation Annual
Meeting, 2003.
183. Nayak NR, Giudice LC, Fazleabas AT. Dynamic expression of
hepatocyte growth factor and its receptor c-met in the baboon uterus
during the menstrual cycle and early pregnancy. Society for Gynecologic
Investigation Annual Meeting, March 2003.
184. Tulac S, Nayak N, Lessey BA, Giudice LC. Identification and
characterization of a canonical Wnt signaling pathway in normal human
endometrium. Society for Gynecologic Investigation Annual Meeting, March
2003.
185. Huang J, Vo KC, Lyell D, Giaccia AJ, Giudice LC. Gene regulations
by hypoxia during brain development. Society for Gynecologic
Investigation Annual Meeting, March 2003.
186. Cataldo NA, Basina M, Abbasi F, McLaughlin T, Reaven GM, Giudice
LC. The ratio of serum triglycerides to high-density lipoprotein (HDL)
cholesterol is associated with insulin resistance in polycystic ovary
syndrome. Pacific Coast Reproductive Medicine Society, April 2003.
187. Lathi RB, Tulac S, Lobo SC, Huang J, Giudice LC. Changes in Gene
Expression in Peripheral Leukocytes, Detected by Microarray Analysis, in
the Secretory vs Proliferative Phase of the Menstrual Cycle. Endocrine
Society Annual Meeting, June 2003.
188. Cataldo NA, Chu JW, Basina M, Abbasi F, McLaughlin TL, Fechner PY,
Giudice LC, Revean GM. Rosiglitazone decreases plasma E-selectin and CRP
in polycystic ovary syndrome (PCOS). Endocrine Society Annual Meeting,
June 2003.
189. Germeyer,A, Brudney A, Huang, J Fazleabas AT, Giudice, LC. Early
changes in the secretory phase eutopic endometrium of the baboon
following the induction of endometriosis. Endocrine Society.Annual
Meeting, June 2003.
190. Nayak NR, Brenner RM, Wiegand SJ, Giudice LC. Blockade of vascular
development in the rhesus macaque endometrium by treatment with
VEGF-Trap: Role of VEGF in postmenstrual repair and angiogenesis. Am Soc
Reproductive Medicine Annual Meeting, Octover 2003.
191. Germeyer A, Brenner RM, Kao L, Giudice LC, Nayak NR. Cell
type-specific expression and regulation of neuropilin-1 and 2 mRNA in
the rhesus macaque endometrium: potential roles for VEGF-neuropilin in
endometrial remodeling during the menstrual cycle in primates. Am Soc
Reproductive Medicine Annual Meeting, October 2003.
192. Tierney EP, Tulac S, Huang J, Giudice LC. Activation of the protein
kinase A pathway during decidualization of human endometrial stromal
cells reveals sequential categorical gene regulation. Am Soc
Reproductive Medicine Annual Meeting, October 2003.
193. Kao LC, Westphal L, Giudice LC. Global expression comparison of
human endometrium between normal individuals and hyperstimulated donors.
Soc Gynecol Invest Annual Meeting, March, 2004.
194. Jun Sh, Hamilton A, Tulac S, Giudice LC, Kao LC. Expression of the
granulin/epithelin (Grn) gene in human endometrium. Soc Gynecol Invest
Annual Meeting, March, 2004.
195. Dosiou C, Hamilton A, Giudice LC. Membrane progesterone receptors
alpha, beta, and gamma are expressed in peripheral blood leukocytes of
menstruating women. Soc Gynecol Invest Annual Meeting, March, 2004.
196. Littman ED, Ulaner GA, Vu TH, Otero J, Dasig D, Lyon J, Gebhardt J,
Giudice LC, Behr B, Hoffman AR. Igf2 gene imprinting in preimplantation
mouse embryos. Pacific Coast Reproductive Society, April 2004
197. Quijntero R, Giudice LC, Westphal LM. Aromatase inhibition of in
vitro fertilization poor responders. Pacific Coast Reproductive Society,
April 2004.
198. Cataldo NA, Abbasi F, McLaughlin TL, Basina M, Fechner PY, Reaven
GM, Giudice LC. Rosiglitazone (ROSI) in Insulin-Resistant Polycystic
Ovary Syndrome (PCOS): Metabolic and Ovarian Effects. International
Federation of Fertility Societies, submitted.
199. Cataldo NA, Abbasi F, McLaughlin TL, Basina M, Fechner PY, Reaven
GM, Giudice LC. Prediction of Ovulatory Response to Rosiglitazone (ROSI)
in Insulin-Resistant Women with Polycyctic Ovary Syndrome (PCOS).
International Federation of Fertility Societies, submitted.
200. Cataldo NA, Abbasi F, McLaughlin TL, Basina M, Fechner PY, Reaven
GM, Giudice LC. Prediction of Ovulatory Response to Rosiglitazone in
Insulin-Resistant Women with Polycyctic Ovary Syndrome (PCOS). Endocrine
Society Annual Meeting, June 2004, submitted.
201. Cataldo NA, Abbasi F, McLaughlin TL, Basina M, Fechner PY, Reaven
GM, Giudice LC. Rosiglitazone in Insulin-Resistant Polycystic Ovary
Syndrome: Metabolic and Ovarian Effects. Endocrine Society Annual
Meeting, June 2004, submitted.
202. Dosiou C, Hamilton AE, Tulac S, Giudice LC. Expression of membrane
progesterone receptors by T lymphocytes in women. International Congress
of Endocrinology June, 2004.