About the author
Linda C. Giudice, PhD, MD
Chief, Reproductive Endocrinology & Infertility
Stanley McCormick Memorial Professor in the School of Medicine
Director, Women’s Health @ Stanford
Director, Center for Research on Women’s Health and Reproduction
Professor of Gynecology and Obstetrics
Chief, Div. Reproductive Endocrinology and Infertility
Associate Chair of Research, Department of Obstetrics and Gynecology
300 Pasteur Drive, HH-333
Stanford, CA 94305-5317
Tel: 650-498-7317
Journal Publications
1. Spaeth EE, Giudice LC, Yin ET: The Dynamics of Activation of
Human Plasma. Circulation XLIV, October, 1971;4, II-220.
2. Yin ET, Giudice LC, Wessler S: Inhibition of Activated Factor
X-induced Platelet Aggregation: The Role of Heparin and the Plasma
Inhibitor to Activated Factor X. J Lab Clin Med 1973;82:390-398.
3. Pierce JG, Faith MR, Giudice LC, Reeve JR: Structure and
Structure-Function Relationships in Glycoprotein Hormones. Ciba
Foundation Symposium 41 (new series), Elsevier/Excerpta Medica, North
Holland 1976;225-250.
4. Pierce JG, Giudice LC, Reeve JR: Studies on the Disulfide Bonds of
Glycoprotein Hormones: The Course of Reduction of Bovine Luteinizing
Hormone, Bovine Thyroid Stimula-ting Hormone, and Their Subunits. J Biol
Chem 1976;251:6388-6391.
5. Pierce JG, Bloomfield GA, Giudice LC: Studies on the Function of the
Common Subunit of Glycoprotein Hormones. Transactions of the Biochemical
Society Great Britain 1976;22:26-28.
6. Giudice LC, Pierce JG: Studies on the Disulfide Bonds of Glycoprotein
Hormones: Complete Reduction and Reoxidation of the Disulfide Bonds of
the a-Subunit of Bovine Luteinizing Hormone. J Biol Chem
1976;251:6392-6399.
7. Giudice LC, Pierce JG: Separation of Functional and Non-Functional
-Subunits of Thyrotropin Preparations by Polyacrylamide Gel
Electrophoresis. Endocrinol 1977;101:776-781.
8. Giudice LC, Pierce JG: Studies of the Reduction and Reoxidation of
the Disulfide Bonds of the and Subunits of Human Choriogonadotropin.
Biochimica et Biophysica Acta 1978;533:140-146.
9. Giudice LC, Pierce JG, Cheng KW, Whitley R, Ryan RJ: Circular
Dichroism of Mammalian Follitropins and the Effects of Treatment with N-Bromosuccinimide.
Biochem and Biophysical Res Communications 1979;81:725-733.
10. Giudice LC, Pierce JG: Studies on the Disulfide Bonds of the
Glycoprotein Hormones: Formation and Properties of 11, 35 bis (S-Alkyl)
Derivatives of the -Subunit. J Biol Chem 1979;254:1164-1169.
11. Giudice LC, Waxdal MJ, Weintraub BD: Comparison of Bovine and Mouse
Pituitary Glycoprotein Hormone Pre-a Subunits Synthesized In Vitro. Proc
Nat Acad Sci, USA 1979;76:4798-4802.
12. Giudice LC, Chaiken IM: Immunological and Chemical Identification of
a Neurophysin-Containing Protein Coded by Messenger RNA from Bovine
Hypothalamus. Proc Nat Acad Sci, USA 1979;76:3800-3804.
13. Giudice LC, Weintraub BD: Evidence for Conformational Differences
Between Precursor and Processed Forms of Thyroid-Stimulating Hormone
Beta Subunit. J Biol Chem 1979;254:12679-12683.
14. Giudice LC, Chaiken IM: Cell-Free Biosynthesis of Different High
Molecular Weight Forms of Bovine Neurophysins I and II Coded by
Hypothalamic mRNA. J Biol Chem 1979;254:11767-11770.
15. Giudice LC, Chaiken IM: Immunological and Chemical Identification of
Bovine Hypothalamic Neurophysin Precursor Synthesized In Vitro. Ann New
York Acad Sci 1979;164:34.
16. Giudice LC, Jacobs AJ, Pineda J, Bell CE, Lippman L: Serum Levels of
CA-125 in Patients with Endometriosis. Fert Steril 1986;45:876-878.
17. Giudice LC, Jacobs AJ, Bell CE, Lippman L: Serum Levels of CA-125 in
Patients with Unusual Gynecologic Malignancies. Gynecol Oncol
1986;25:184-187.
18. Lamb EJ, Polansky FP, Milki A, Giudice LC, Friedler S: Clinical
Results of Stanford University’s In Vitro Fertilization and Embryo
Transfer Program. J In Vitro Fert Embryo Transfer 1987;4:188-189.
19. Sauer MV, Macaso TM, Ishida EH, Giudice LC, Marshall HR, Buster JE:
Pregnancy Following Nonsurgical Donor Ovum Transfer to a Functionally
Agonadal Woman, Fertility and Sterility 1987;48, 324-325.
20. Kivikoski AI, Martin C, Weyman P, Picus D, Giudice LC: Angiographic
Arterial Embolization to Control Hemorrhage in Abdominal Pregnancy: A
Case Report. Obstet Gynecol 1988;71:456-459.
21. Friedler S, Giudice LC, Lamb EJ: Cryopreservation of Embryos and
Ova. Fert Steril 1988;49:743-764.
22. Lamson G, Oh Y, Pham H, Giudice LC, Rosenfeld RG: Expression of Two
Insulin-like Growth Factor Binding Proteins in a Human Endometrial
Cancer Cell Line: Structural, Immunologic and Genetic Characterization.
J Clin Endocrinol Metab 1989;69:852-859.
23. Rosenfeld RG, Hung P, Lamson GL, Giudice LC: Insulin-like Growth
Factor Binding Proteins in Human Seminal Plasma. J Clin Endocrinol Metab
1989;70:551-553.
24. Giudice LC: Gonadotropin-Releasing Hormone Agonist Treatment of
Endometriosis and Myomas. Western J Med 1990;152:409.
25. Rosenfeld RG, Lamson G, Pham H, Oh YM, Conover C, DeLeon DD, Donovan
SM, Ocrant I, Giudice LC: Insulin-like Growth Factor Binding Proteins.
Recent Prog Hormone Res 1990;46:99-163.
26. Giudice LC, Farrell EM, Pham H, Rosenfeld RG: Insulin-like Growth
Factor Binding Proteins in Maternal Serum Throughout Gestation and in
the Puerperium: Effects of a Serum Protease Activity. J Clin Endocrinol
Metab 1990;71:806-816.
27. Giudice LC, Farrell EM, Pham H, Rosenfeld RG: Identification of
Insulin-like Growth Factor-Binding Protein-3 (IGF-BP-3) and IGF-BP-2 in
Human Follicular Fluid. J Clin Endocrinol Metab 1990;71:1330-1338.
28. Giudice LC, Milkowski DA, Lamson G, Rosenfeld RG, Irwin JC:
Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) and IGFBP-3 in
Human Endometrium: Steroid-Dependent Messenger RNA Expression and
Protein Synthesis. J Clinical Endocrinol Metab 1991;72:779-787.
29. Giudice LC, Lamson G, Rosenfeld RG, Irwin JC: Insulin-like growth
factor-II (IGF-II) and IGF Binding Proteins in Human Endometrium. Ann
New York Acad Sci 1991;646:295-307.
30. Lamson G, Giudice LC, Rosenfeld RG: A Simple Assay for Proteolysis
of Insulin-like Growth Factor Binding-3. J Clinical Endocrinol Metab
1991;72:1391-1393.
31. Giudice LC, Milkowski DM, Fielder PJ, Irwin J: Characterization of
the Steroid-Dependence of Insulin-like Growth Factor Binding Protein-2
Synthesis and mRNA Expression in Cultured Human Endometrial Stromal
Cells. Hum Reprod 1991;6:632-640.
32. Giudice LC, Milki AA, Milkowski D, El-Danasouri I: Human Granulosa
Contain Messenger Ribonucleic Acids Encoding Insulin-like Growth Factor
Binding Proteins (IGFBPs) and Secrete IGFBPs in Culture. Fert Steril
1991;56:475-480.
33. Lamson G, Giudice LC, Rosenfeld RG: Insulin-like Growth Factor
Binding Proteins: Structural and Molecular Relationships. Growth Factors
1991;5:19-28.
34. Cohen P, Fielder PJ, Hasegawa Y, Frisch H, Giudice LC, Rosenfeld RG:
Clinical Aspects of Insulin-like Growth Factors. Acta Endocrinologica
1991;124(suppl 2):74-85.
35. Giudice LC, Dsupin BA, and Irwin JC: Identification of Insulin-like
Growth Factor Binding Proteins in Human Oviduct. Fert Steril
1992;57:294-301.
36. Cataldo NA and Giudice LC: Insulin-like Growth Factor Binding
Protein Profiles in Follicular Fluid in Polycystic Ovarian Syndrome. J
Clin Endocrinol Metab 1992;74:695-697.
37. Cataldo NA and Giudice LC: Insulin-like Growth Factor Binding
Protein Profiles in Human Ovarian Follicular Fluid Correlate with
Follicular Functional Status. J Clin Endocrinol Metab 1992;74:821-829.
38. Donovan SM, Giudice LC, Murphy LJ, Hintz RL, Rosenfeld RG:
Insulin-like Growth Factor Binding Protein Expression During Pregnancy
in the Rat. Endocrinol 1991;129:3359-3366.
39. Cohen P, Ocrant I, Fielder PJ, Neely EK, Gargosky SE, Deal CL, Ceda
GP, Oh Y, Pham H, Lamson G, Giudice LC, Rosenfeld RG: Insulin-like
Growth Factors (IGFs): Implications for Aging. Psychoneuroendocrinology
1992;17:333-340.
40. Cohen P, Graves HCB, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG:
Prostate Specific Antigen (PSA) Is An IGF Binding Protein-3 (IGFBP-3)
Protease Found in Seminal Plasma. J Clin Endocrinol Metab
1992;75:1046-1053.
41. Giudice LC, Dsupin BA, Irwin JC: Steroid and Peptide Regulation of
Insulin-like Growth Factor Binding Proteins Secreted by Human
Endometrial Stromal Cells is Dependent on Stromal Differentiation. J
Clin Endocrinol Metab 1992;75:1235-1241.
42. Giudice LC: Insulin-like Growth Factors and Ovarian Follicular
Development. Endocrine Rev 1992;13:641-669.
43. Milki A, Hardy RE, El Danasouri I, Giudice LC, Lamb EJ. Local
Anesthesia for Laparoscopic Intrafallopian Transfer. Fert Steril
1992;58:1240-1242.
44. Gargosky SE, Pham HM, Wilson KF, Liu F, Giudice LC, Rosenfeld RG.
Measurement and Characterization of Insulin-like Growth Factor Binding
Protein-3 in Human Biological Fluids: Discrepancies Between
Radioimmunoassay and Ligand Blotting Reflect Protease Activity.
Endocrinol 1992;131:3051-3060.
45. Woodruff TK, Battaglia J, Bowdidge A, Molskness TA, Stouffer,
Cataldo NA, Giudice LC, Orly J, Mather JP. A Comparison of Functional
Response of Rat, Macaque, and Human Ovarian Cells in Hormonally Defined
Medium. Biol Reprod 1993;48:68-76.
46. Cataldo NA, Woodruff TK, Giudice LC: Regulation of Insulin-like
Growth Factor Binding Protein Production by Human Luteinizing Granulosa
Cells Cultured in Defined Medium. J Clin Endocrinol Metab
1993;76:207-215.
47. Rodgers WH, Osteen KG, Matrisian LM, Navre M, Giudice LC, Gorstein
F. Expression and Localization of Matrilysin (PUMP-1, MMP-7), a Matrix
Metalloproteinase, in Human Endometrium During the Reproductive Cycle.
Amer J Obstet Gynecol 1993;168:253-260.
48. Giudice LC, Dsupin BA, De Las Fuentes L, Gargosky SM, Rosenfeld RG,
Zelinski-Wooten M, Stouffer D, Fazleabas A: Insulin-like Growth Factor
Binding Proteins in Sera of Pregnant Nonhuman Primates. Endocrinol
1993;1514-1526.
49. Giudice LC, Dsupin BA, Vu TH, Lin IL, Hoffman AR: Differential
Expression of mRNAs Encoding Insulin-like Growth Factors and Their
Receptors in Human Endometrium During the Menstrual Cycle and in Early
Pregnancy. J Clin Endocrinol Metab 1993;76:1115-1122.
50. Lamson G, Giudice LC, Cohen P, Liu F, Gargosky S, Muller HL, Oh Y,
Wilson KF, Hintz RL, Rosenfeld RG: Proteolysis of IGFBP-3 may be a
common regulatory mechanism of IGF action in vivo. Growth Regulation
1993;3:91-95.
51. Giudice LC, Chandrasekher YA, Cataldo NA: Normal Mechanisms of
Reproductive Physiology: The Potential Roles of Intraovarian Peptides.
Current Opinion Obstet Gynecol 1993;5:350-359.
52. Sanders LM, Giudice LC, Raffin TA: Ethics of Fetal Tissue
Transplantation. Western J Med 1993;159:400-407.
53. Irwin JC, Dsupin BA, De la Fuentes L, Giudice LC: Insulin-like
Growth Factor (IGF) Regulation of Human Endometrial Stromal Cell
Function: Coordinate Effects on IGF Binding Protein-1, Cellular
Proliferation, and Prolactin Secretion. Reg Peptides 1993;48:165-177.
54. Giudice LC, Irwin JC, Dsupin BA, Pannier EM, Lin IH, Vu TH, Hoffman
AR: Insulin-like Growth Factor (IGF) and IGF Binding Protein (IGFBP)
Gene Expression and IGFBP Synthesis in Human Uterine Leiomyomata. Hum
Reprod 1993;8:1796-1806.
55. Gargosky SE, Pham HM, Wilson KF, Giudice LC, Rosenfeld RG:
Comparative use of immunological and ligand blotting of IGFBPs in serum
and other biological fluids. Clin Pediatrics Endocrinol Suppl 2
1993;2:21-29.
56. Giudice LC. Growth Factors and Growth Modulators in Human
Endometrium: Their Potential Relevance to Reproductive Medicine. Fert
Steril 1994;61:1-17.
57. Gordon JD, Morris EF, Jeffrey BA, Giudice LC: Use of Color Doppler
Sonography and Conservative Management of a Patient with Ovarian
Torsion. Fert Steril 1994;61:383-385.
58. Giudice LC: Insulin-like Growth Factors in Normal and Abnormal Human
Follicular Development, American Journal of Medicine 1994;98(suppl
1A):48S-54S.
59. Giudice LC: Molecular Regulation of Endometrial Growth. Contemp
OB/GYN, 1994;39:85-104.
60. Bang P, Giudice LC, Rosenfeld RG: Insulin-like Growth Factors (IGF)
and IGF Binding Proteins as Endocrine Growth Factors in the Human Fetus
and Neonate. Ares-Serono Symposia: Frontiers in Endocrinology:
Developmental Endocrinology. 1994;vol 6: Rome;pp. 197-212.
61. Pannier EM, Irwin JC, Giudice LC: Insulin-like Growth Factor Binding
Proteins in the Human Fetus: Tissue-specific Protein Secretion,
Immunologic Characterization, and Gene Expression. Am J Obstet Gynecol
1994;171:746-752.
62. Rodgers WH, Matrisian LM, Giudice LC, Dsupin BA, Svetik C, Gorstein
F, Osteen KG. Patterns of Matrix Metalloproteinase Expression in Cycling
Endometrium Imply Differential Functions and Regulation by Steroid
Hormones. J Clin Invest 1994;94:946-953.
63. Giudice LC, Gargosky SE, Dsupin BA, Rosenfeld RG, Irwin JC: The
Insulin-like Growth Factor System in Human Peritoneal Fluid: Its Effects
on Endometrial Stromal Cells and Its Potential Relevance to
Endometriosis. J Clin Endocrinol Metab 1994;79:1284-1293.
64. Nonoshita L, Dsupin BA, Wathen NC, Chard T, Giudice LC: Insulin-like
Growth Factors (IGF) and IGF Binding Proteins in Embryonic Cavities in
Early Human Pregnancy: Potential Relevance to Maternal-Embryonic
Communication. J Clin Endocrinol Metab 1994;79:1249-1255.
65. Lee KO, Oh Y, Giudice LC, Cohen P, Peehl DM, Rosenfeld RG.
Identification of Insulin-like Growth Factor Binding Protein (IGFBP)-3
Fragments, and IGFBP-5 Proteolytic Activity in Human Seminal Plasma: A
Comparison of Normal and Vasectomized Patients. J Clin Endocrinol Metab,
1994;79:1367-1372.
66. Zhou J, Dsupin BA, Giudice LC, Bondy C: Insulin-like Growth Factor
(IGF), IGF Binding Protein, and IGF receptor Gene Expression in Human
Endometrium. J Clin Endocrinol Metab 1994;79:1723-1734.
67. Irwin JC, de las Fuentes L, Giudice LC: Growth Factors and
Decidualization In Vitro. Annals of the New York Academy of Sciences,
1994;734:7-18.
68. Irwin JC, Dsupin BA, Giudice LC: Posttranslational Regulation of
Insulin-like Growth Factor Binding Protein-4 in Human Endometrial
Stromal Cultures: Evidence for a Novel Mechanism of Ligand-Induced
Proteolysis. J Clin Endocrinol Metab 1995;80:619-626.
69. Giudice LC, de Zegher F, Gargosky SM, Dsupin BA, de las Fuentes L,
Crystal RA, Hintz RL, Rosenfeld RG: Insulin-like Growth Factors and
Their Binding Proteins in Term and Pre-term Human Fetus and Neonate with
Normal and Extremes of Intrauterine Growth. J Clin Endocrinol Metab,
1995;80:1548-1555.
70. Giudice LC, Saleh W: Growth Factors in Reproduction. Trends in
Endocrinology and Metabolism, 1995;6:60-69.
71. Cummings LN, Giudice LC, Morrell MJ: Ovulatory Function in Epilepsy.
Epilepsia 1995;36:355-359.
72. Seifer DB, Giudice LC, Dsupin BA, Haning RV, Frishman GN, Burger HG:
Follicular fluid insulin-like growth factor-I and insulin-like growth
factor-II concentrations vary as a function of day 3 serum follicle
stimulating hormone. Hum Reprod 1995;10:804-806.
73. Giudice LC: Endometrial Growth Factors and Proteins. Seminars in
Reprod Endocrinol 1995; 13:93-101.
74. Giudice LC: Editorial: IGF Binding Protein-3 Protease Regulation:
How Sweet It Is! J Clin Endocrinol Metab 1995;80:2279-2281.
75. Madsen BL, Giudice LC, Donaldson SS: Radiation Induced Premature
Menopause: A Misconception. International Journal of Radiation Oncology,
Biology and Physics, 1995;32:1461-1464.
76. Chandrasekher YA, van Dessel HJHM, Fauser BCJM, Giudice LC:
Estrogen- But Not Androgen-Dominant Human Ovarian Follicular Fluid
Contains an Insulin-like Growth Factor Binding Protein-4 Protease. J
Clin Endocrinol Metab, 1995;80:2734-2739.
77. Gargosky SE, Giudice LC, Rosenfeld RG, Fazleabas AT. Different
Molecular and mRNA Forms of Insulin-like Growth Factor Binding Protein-3
in the Pregnant Baboon Papio Anubis. J Endocrinol 1995;147:449-461.
78. Irwin JC, Kirk D, Gwatkin RBL, Sachs H, Navre M, Cannon P, Dsupin
BA, Giudice LC: Human Endometrial Matrix Metalloproteinase-2 (MMP-2):
Hormonal Regulation of Stromal Cell Secretion and Messenger RNA
Expression during the Menstrual Cycle and Potential Role as a Menstrual
Proteinase, J Clin Invest, 1996;97:438-447.
79. Van Dessel HJHM, Faessen G, Yap OWS, Chandrasekher YA, Fauser BCJM,
Giudice LC: Serum and Follicular Fluid Levels of Insulin-like Growth
Factor (IGF)-I, IGF-II, and IGF Binding Proteins-1 and -3 During the
Normal Menstrual Cycle. J Clin Endocrinol Metab, 1996;81:1224-1231.
80. Poretsky L, Chandrasekher YA, Bai C, Liu HC, Rosenwaks Z, Siddle K,
Giudice LC: Insulin but not IGF-I Inhibits IGF Binding Protein-1
(IGFBP-1) Production in Human Granulosa Cells Via the Insulin Receptor.
J Clin Endocrinol Metab, 1996;81(2):493-496.
81. Klein NA, Battaglia DE, Miller PB, Giudice LC, Soules MR. Ovarian
Follicular Development and the Follicular Fluid Environment (Hormones
and Growth Factors) in Normal Women of Advanced Reproductive Age. J Clin
Endocrinol Metab, 1996;81(5):1946-1951.
82. Giudice LC, Cataldo NA, van Dessel HJHM, Yap OWS, Chandrasekher YA.
Growth factors in normal ovarian follicle development. Sem Reprod
Endocrinol 1996;14:179-196.
83. Giudice LC, Morales AJ, Yen SSSC. Growth factors and polycystic
ovarian syndrome. Sem Reprod Endocrinol 1996;14:201-208.
84. Tazuke SI, Giudice LC. Growth factors and cytokines in endometrium,
embryonic development, and maternal:embryonic interactions. Sem Reprod
Endocrinol 1996;14:231-246.
85. Taskin O, Dsupin BA, Wiehle RD, Giudice LC. Insulin-like Growth
Factor Binding Protein-3 (IGFBP-3) and IGFBP-3 Protease in Peritoneal
Fluid of Women with Minimal and Mild Endometriosis. Human Reprod
1996;11:312-320.
86. Homburg R, Giudice LC, Chang RJ. Editorial. Polycystic Ovary
Syndrome: Update. Human Reprod 1996;11:465-466.
87. Giudice LC, Martina NA, Crystal RA, Tazuke S, ML Druzin:
Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) at the
Maternal-Fetal Interface and IGF-I, IGF-II, and IGFBP-1 in the
Circulation of Women with Severe Pre-eclampsia. Am J Obstet Gynecol
1997;176:751-757.
88. Sharara FI, Giudice LC. Role of Growth Hormone (GH) in Ovarian
Physiology and Onset of Puberty. J Soc Gyn Invest 1997;4:2-7.
89. Amara DP, Nezhat F, Giudice LC, Nezhat C. Laparoscopic Management of
a Noncommunicating Uterine Horn in a Patient with an Acute Abdomen.
Surgical Laparoscopy and Endoscopy. 1997;7:56-59.
90. Martina NA, Kim E, Chitkara U, Wathen NC, Chard T, Giudice LC:
Gestational Age-Dependent Expression of IGF Binding Protein-1 (IGFBP-1)
Phosphoisoforms in Human Extra-Embryonic Cavities, Maternal Serum, and
Decidua Suggests Decidua as the Primary Source of IGFBP-1 in These
Fluids During Early Pregnancy. J Clin Endocrinol Metab
1997;83:1894-1898.
91. Yap OWS, Chandrasekher YA, van Dessel HJHM, Fauser BJCM, Giudice LC:
Similar Insulin-like Growth Factor Binding Protein Profiles in
Androgen-dominant Follicular Fluid from Normal, Polycystic Ovary
Syndrome, and Androgen-Treated Female-to Male Transsexual Human Ovaries.
Fertility Sterility, 1997;68:252-258.
92. Ulaner GA, Giudice LC: Telomerase Activity in Human Fetal Tissue
During Gestation, Molec Human Reprod, 1997;3:769-773.
93. Yuan W, Giudice LC. Programmed Cell Death in Human Ovary is a
Function of Follicle and Corpus Luteum Status, J Clin Endocrinol Metab
1997;82:3148-3155.
94. Lee PDK, Conover CA, Giudice LC, Powell DP. IGFBP-1: New Perspective
on Function and Regulation. Proc Soc Expt Biol Med, 1997;216:319-357.
95. Irwin JC, Giudice LC: Insulin-like Growth Factor Binding Protein-1
Binds to Cytotropho-blast 51 Integrin and Inhibits Cytotrophoblast
Invasion into Decidual Multilayers. Growth Hormone and IGF Research
1998;8:21-31.
96. Azhar S, Tsai L, Medicherla S, Giudice LC, Reaven E. Human granulosa
cells use HDL-Cholesterol for Steroidogenesis. J Clin Endocrinol Metab.
1998;83:983-991.
97. Tazuke SI, Mazure N, Crystal RA, Carland G, Faessen GH, Suen LF,
Sugawara J, Powell D, Giaccia A, Giudice LC: Hypoxia Regulation of
IGFBP-1 Gene Expression and Its Relevance to Intrauterine Fetal Hypoxia
in Human Pregnancy, Proc Natl Acad Sci (USA), 1998;95:10188-10193.
98. Ulaner GU, Jifan T, Vu T, Giudice LC, Hoffman AR. Telomerase
activity in human development is regulated both by hTERT transcription
and by alternate splicing of hTERT transcripts. Cancer Research
1998;58:4168-4172.
99. Giudice LC, Swiersz L, Tazuke SI. Current Research in Endometriosis.
J Reprod Med, 1998;43:252-262.
100. Fisch J, Tazuke SI, Ortiz BH, Chitkara U, Giudice LC. Medical
Management of Interstitial Ectopic Pregnancy: A Case Report and Review
of the Literature. Human Repro, 1998;13:1981-86.
101. Yap OWS, Chandrasekher YA, Giudice LC. Growth Factor Regulation of
Insulin-like Growth Factor Binding Protein Secretion by Cultured Human
Granulosa-Luteal Cells. Fertil Steril 1998;70:535-540.
102. Yuan W, Giudice LC: IGF-II Mediates the Steroidogenic and Growth
Promoting Actions of Follicle Stimulating Hormone on Human Ovarian
Pre-antral Follicles In Vitro. J Clin Endocrinol Metab,
1999:84:1479-1482.
103. Giudice LC, An Overview of Genes Associated with Embryonic
Attachment and Implantation and the Role of Progesterone. J Reprod Med
1999;44:165-171.
104. Popovici R, Irwin JC, Giaccia A, Giudice LC. Hypoxia and cAMP
stimulate vascular endothelial growth factor (VEGF) in human endometrial
stromal cells: potential relevance to menstruation and endometrial
regeneration. J Clin Endocrinol Metab 1999;84:2245-2248.
105. Giudice LC, Irwin JC. Roles of the Insulin-like Growth Factor (IGF)
Family in Non-Pregnant Human Endometrium and at the Decidual:trophoblast
Interface. Sem Reprod Endocrinol, 1999;17:13-21.
106. Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC. Insulin-related
Regulatory System in the Ovary in Health and Disease. Endocrine Reviews,
1999;20:535-582.
107. van Dessel HJHM, Lee PDK, Faessen GH, Chandrasekher YA, Fauser
BCJM, Giudice LC: Elevated Serum Levels of Free Insulin-like Growth
Factor (IGF)-I in Polycystic Ovary Syndrome. J Clin Endocrinol Metab
1999;84:3030-3035.
108. Conover C, Oxvig C, Overgaard MT, Christiansen M, Giudice LC.
Evidence that the Insulin-like Growth Factor Binding Protein-4 Protease
in Human Ovarian Follicular Fluid is Pregnancy Associated Plasma
Protein-A. J Clin Endocrinol Metab 1999;.84:4742-4745.
109. Giudice LC. Potential Biochemical Markers of Uterine Receptivity.
Human Reprod 1999;14:3-16.
110. Irwin JC, Suen L-F, Martina NA, Mark SP, Giudice LC. Role of the
IGF System in Trophoblast Invasion and Pre-eclampsia”. Human Reprod
1999,14:90-96.
111. Irwin JC, Suen L-F, Cheng B-H, Martin R, Cannon P, Deal CL, Giudice
LC. Human Placental Trophoblasts Secrete a Disintegrin Metalloproteinase
Very Similar to the Insulin-like Growth Factor Binding Protein-3
(IGFBP-3) Protease in Human Pregnancy Serum. Endocrinology
2000;141:666-672.
112. Sugawara J, Suh D-S, Gaessen GH, Shibata T, Kaper F, Giaccia AJ,
Giudice LC. Regulation of Insulin-like Growth Factor Binding Protein-1
Expression by Nitric Oxide Under Hypoxic Conditions. J Clin Endocrinol
Metab, 2000, 85:2714-21.
113. Popovici RM, Kao L-K, Giudice LC. Discovery of New Inducible Genes
in In Vitro Decidualized Human Endometrial Stromal Cells Using
Microarray Technology. Endocrinology, 2000; 141:3510-3.
114. Imani B, Eijkemans MJC, de Jong FH, Bouchard P, Giudice LC, Fauser
BCJM. Free Androgen Index And Leptin Are The Most Prominent Endocrine
Predictors Of Ovarian Response During Clomiphene Citrate Induction Of
Ovulation In Normogonadotropic Oligo/Amenorrheic Infertility. J Clin
Endocrinol Metab 2000, 85:676-682.
115. Sugawara J, Tazuke SI, Suen L-F, Kaper F, Powell DR, Giaccia AJ,
Giudice LC. Regulation of Insulin-like Growth Factor Binding Protein-1
(IGFBP-1) by hypoxia and 3’,5’-cyclic adenosine monophosphate is
additive in HepG2 Cells, J Clin Endocrinol Metab 2000;85:3821-3827.
116. Giudice LC. The Insulin-like Growth Factor Family in Graafian
Follicle Development and Function. J Soc Gynecol Invest 2001;S26-S29.
117. Rivera GM, Chandrasekher YA, Evans ACO, Giudice LC, and Fortune JE.
A potential role for insulin-like growth factor binding protein-4
proteolysis in the establishment of ovarian follicular dominance in
cattle. Biol Reprod 2001;65:102-111.
118. Popovici RM, Lu M, Bhatia S, Faessen GH, Giaccia AJ, Giudice LC.
Hypoxia regulates IGFBP-1 in Human Fetal Hepatocytes in Primary Culture:
Suggestive Molecular Mechanisms for Fetal Growth Restriction Due to
Uteroplacental Insufficiency. J Clin Endocrinol Metab 2001,
86(6);2653-2659.
119. Klein NA, Battaglia DE, Woodruff TK, Padmanabhan V, Giudice LC,
Bremner WJ, Soules MR. Ovarian Follicular Concentrations of Activin,
Follistatin, Inhibin, IGF-I, IGF-II, IGFBP-2, IGFBP-3, and VEGF in
spontaneous menstrual cycles of normal women of advanced reproductive
age. J Clin Endocrinol Metab. 2001, 85(12):4520-4525.
120. Irwin JC, Suen L-F, Faessen GH, Popovici RM, Giudice LC,
Insulin-like Growth Factor-II (IGF-II) Inhibition of Endometrial Stromal
Cell Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) and IGF Binding
Protein-1 (IGFBP-1) Suggests Paracrine Interactions at the
Decidual:Trophoblast Interface During Human Implantation. J Clin
Endocrinol Metab. 2001; 86:2060-2064.
121. Conover CA, Faessen GF, Ilg KE, Chandrasekher Y Aladin,
Christiansen M, Overgaard MT, Oxvig, C, Giudice LC. Pregnancy-associated
plasma protein-A is the insulin-like growth factor binding protein-4
protease secreted by human ovarian granulosa cells and is a marker of
dominant follicle selection and the corpus luteum. Endocrinology 2001,
142(5):2155.
122. Verhaeghe J, Billen J, Giudice LC. Insulin-like growth factor
binding protein-1 in umbilical artery and vein of term fetuses with
signs of distress during labour. J Endocrinol 2001, 170:585-90.
123. Laursen LS, Overgaard MT, Soe R, Boldt H, Sottrup-Jensen L, Giudice
LC, Conover CA, Oxvig C. Pregnancy-associated plasma protein-A (PAPP-A)
cleaves insulin-like growth factor binding protein-5 independent of IGF:
implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS
Lettrs 2001;504:36-40.
124. Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR. Tissue-specific
alternate splicing of human telomerase reverse transcriptase (hTERT)
influences telomere length during human development. Intl J Cancer
2001;91(5):644-649.
125. Imani B, Marinus JC, Eijkemans MJC, Faessen GH, Bouchard P, Giudice
LC, Fauser BCJM. Prediction of the individual follicle-stimulating
hormone threshold for gonadotropin induction of ovulation in
normogonadotropic anovulatory infertility: an approach to increase
safety and efficiency. Fert Steril 2002, 77(1):83-90.
126. Giudice LC, Telles TL, Lobo S, Kao, LC. The molecular basis for
implantation failure in endometriosis: on the road to discovery. In:
Proceedings of the NIH Workshop on Endometriosis: Emerging Research and
Intervention Strategies IN. Yoshinaga and E. Parrot, eds). Annals New
York Acad Sci; 2002;955:252-280.
127. Bhatia S, Faessen GH, Carland G, Balise RL, Gargosky SE, Druzin M,
El-Sayed Y, Wilson DM, Giudice LC. A longitudinal analysis of maternal
serum IGF-I and total and non-phosphoryl-ated IGFBP-1 in human
pregnancies complicated by intrauterine growth restriction. J Clin
Endocrinol Metab, 2002;87:1864-1870.
128. Giudice LC, Conover CA, Bale L, Faessen GH, Ilg K, Sun I, Imani B,
Suen L-F, Irwin JC, Christiansen M, Overgaard MT, Oxvig C.
Identification and regulation of the IGFBP-4 protease and its
physiological inhibitor in human trophoblasts and endometrial stroma:
evidence for paracrine regulation of IGF-II bioavailability in the
placental bed during human implantation. J Clin Endocrinol Metab 2002
87: 2359-2366.
129. Kao LC, Yang J-P, Tulac S, Suh DS, Taylor RN, Osteen K, Lessey BD,
Giudice LC. Global gene profiling in human endometrium during the window
of implantation. Endocrinol 2002; 143(6): 2119-2138.
130. Giudice LC. Maternal-fetal conflict – lessons from a transgene.
(Editorial) J Clin Invest 2002;110:307-309.
131. Morrell M, Giudice LC, Flynn K, Seale C, Paulson A, Done S, Flaster
E, Ferin M, Sauer M. Anovulation in Women with Epilepsy: Syndrome or
Treatment, Cairn S. Brain 2002-00281,
132. Sun I, Oxvig C, Overgaard MT, Giudice LC. Pregnancy-associated
plasma protein a proteolytic activity is associated with the human
placental trophoblast cell membrane. J Clin Endocrinol Metab 2002:87:
5235-5240.
133. Taylor RN, Lundeen SG, Giudice LC. Emerging role of genomics in
endometriosis research. Fertil Steril 2002;78(4):694-698.
134. Milki AA, Jun S, Hinckley MD, Westphal LM, Giudice LC, Behr B. Does
blastocyst transfer alter the sex ratio? One program’s experience and
review of the literature. Fertil Steril 2002;78(Suppl 1): S244.
135. Laursen LS, Overgaard MT, Weyer K, Boldt HB, Ebbesen P,
Christiansen M, Sottrup-Jensen L, Giudice LC, Oxvig C. Cell surface
targeting of pregnancy-associated plasma protein-A proteolytic activity.
Reversible adhesion is mediated by two neighboring short consensus
repeats. J. Biol. Chem. 2002; 277:47225-34.
136. Soe R, Overgaard MT, Thomsen AR, Laursen LS, Olsen IM,
Sottrup-Jensen L, Haaning J, Giudice LC, Conover CA, Oxvig C. Expression
of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and
a novel variant (PAPP-Ai) with differential proteolytic activity. Eur.
J. Biochem. 2002;269:2247-56
137. Laursen LS, Overgaard MT, Nielsen CG, Boldt HB, Hopmann KH, Conover
CA, Sottrup-Jensen L, Giudice LC, Oxvig C. Substrate specificity of the
metalloproteinase pregnancy-associated plasma protein-A (PAPP-A)
assessed by mutagenesis and analysis of synthetic peptides: substrate
residues distant from the scissile bond are critical for proteolysis.
Biochem. J. 2002;367:31-40
138. Mooney SA, Giudice LC. Endocrinology of Pregnancy.
www,ENDOTEXT.org, 2002
139. Lathi R, Bessina M, L Swiersz, Giudice LC: The endometrium in
hyperinsulinemic states. In, Nestler J, Current Opin Endocrinol
Diabetes. 2002;9:480-485.
140. Verhaeghe J, Van Herck E, Billen J, Moerman P, Van Assche FA,
Giudice LC. Regulation of insulin-like growth factor-I and insulin-like
growth factor binding protein-1 concentrations in preterm fetuses. 2002,
Am J Obstet Gynecol, 2003;188:485-491.
141. Nayak N, Giudice LC. Comparative biology of the IGF system in
endometrium, decidua, and placenta, and clinical implications for fetal
growth and implantation disorders. Placenta, 2003;24:281-296.
142. Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, Taylor RN, Osteen K,
Lessey BD, Giudice LC: Expression profiling of endometrium from women
with endometriosis reveals candidate genes for disease-based
implantation failure and infertility. Endocrinology 2003;144:2870-2881.
143. Giudice LC. Genomics role in understanding the pathogenesis of
endometriosis. Seminars in Reproductive Medicine 2003;21:119-124.
144. Lyell D, Messerlian GL, Giudice LC: Predictors of pre-eclampsia.
Clinics in Laboratory Medicine: Prenatal Testing, 2003;23:413-442.
145. Giudice LC. Elucidating human endometrial function in the
post-genomic era. Hum Reprod Update, 2003;9:223-235.
146. Tulac S, Kao LK, Nayak N, Giudice LC. Identification,
characterization, and regulation of the canonical Wnt signaling pathway
in human endometrium. J Clin Endocrinol Metab, 2003;88: 3860-3866.
147. Overgaard MT, Glerup S, Boldt HB, Rodacker V, Olsen IM,
Christiansen M, Sottrup-Jensen L, Giudice LC, Oxvig C. Proteolysis by
the proform of eosinophil major basic protein requires covalent binding
to its target proteinase. FEBS Lettr 2004;28103:1-6.
148. Tierney EP, Tulac S, Huang S-T J, Giudice LC. Activation of the
protein kinase A in human endometrial stromal cells reveals sequential
categorical gene regulation. Physiologic Genomics, 2003;16:47-66.
149. Morrell MJ, Giudice LC, Flynn K, Seale C, Paulson A, Done S,
Flaster E, Ferin M, Sauer M. Ovulatory dysfunction in women with
epilepsy receiving antiepileptic drug monotherapy: an interaction of
syndrome and treatment. Neurology, 2004, in press.
150. Tierney EP, Giudice LC. Role of activin A as a mediator of in vitro
endometrial stromal cell decidualization via the cAMP pathway. Fertil
Steril, 200481;suppl#1:899-903.
151. Weyer K, Overgaard MT, Laursen LS, Nielsen CG, Schmitz A,
Christiansen M, Sottrup-Jensen L, Giudice LC, Oxvig C. Cell surface
adhesion of pregnancy-associated plasma protein-A is mediated by four
clusters of basic residues located in its third and fourth CCP module.
Eur J Biochem 2004;271:1525-1535.
152. Littman ED, Ulaner GA, Vu TH, Otero J, Dasig D, Lyon J, Gebhardt J,
Giudice LC, Behr B, Hoffman AR. Igf2 gene imprinting in preimplantation
mouse embryos. Fertil Steril 2004; 81 (Suppl 3) p.14.
153. Dosiou C, Lathi RB, Tulac S, Lobo SC, Huang S-T J, Giudice LC.
Interferon-related and other immune genes are down-regulated in
peripheral blood leukocytes in the luteal phase of the menstrual cycle.
J Clin Endocrinol Metab, 2004; 89(5) pp. 2501-2504.
154. Huang S-T J, Vo KC, Lyell DJ, Faessen GH, Tulac S, Giaccia AJ,
Giudice LC. Developmental
response to hypoxia. FASEB J, 2004 in press.
155. Coutifaris C, Myers ER, Guzick DS, Diamond MP, Carson SA, Legro RS,
McGovern PG, Schlaff WD, Carr BR, Steinkampf MP, Silva S, Barnhart K,
Leach RE, Buster JE, Dodson WC, Albert J, Hill JA, Ginsburg E,
Overstreet JW, Nakajima ST, Giudice LC, Vogel DL, Leppert PC.
Histological dating of timed endometrial biopsy tissue is not related to
fertility status, Fertil Steril, 2004 , in press.
156. Littman ED, Milki AA, Lathi RB, Westphal LM, Giudice LC, Nezhat CR.
The role of laparoscopy in patients who have failed in vitro
fertilization. Fertil Steril, 2004, in press.
157. Dosiou C, Giudice LC. The role of natural killer cells in pregnancy
and recurrent spontaneous pregnancy loss. Endocrine Reviews, under
revision, 2004.
158. Giudice LC. Microarray expression profiling reveals candidate genes
for human uterine receptivity. Am J Pharmacogenomics. 2004.
159. Giudice LC. Endometriosis: A Complex Disorder with Complex
Solutions. Lancet (Seminar), 2004, under review.
160. Lobo SC, Huang J, Vo KC, Germeyer A, Tulac S, Nayak N, Giudice LC.
The immune environment in human endometrium during the window of
implantation. Under review.
161. Chandrasekher YA, Faessen GF, Overgaard MT, Christiansen M, Clark
C, Conover CA, Oxvig C, Giudice LC. Synergistic regulation of
insulin-like growth factor binding protein-4 proteolysis by IGF-II and
follicle stimulating hormone in human ovarian granulosa in vitro. Under
review.
162. Hamilton A, Nayak N, Vo KC, Alles L, Weissman I, Giudice LC. Stem
cell markers in human endometrial functionalis and basalis reveal
cell-specific expression. Fertil & Steril, under review.
163. Tulac S, Hamilton A, Zuchereck S, Giudice LC. Silencing of lamin in
human endometrial stromal cells promotes emerin dispersal from the
nuclear lamina to the cytoplasm. Biol of Reprod, under review.
164. Lathi R, Hess A, Hamilton A, Vo KC, Nayak N, Conti MC, Giudice LC.
Insulin signaling in human endometrial stromal cells. Under review, J
Clin Endocrinol Metab 2004.
165. Boldt HB, Kjaer-Sorensen K, Overgaard MT, Weyer K, Sottrup-Jensen
L, Conover CA, Giudice LC, Oxvig C. The Lin12-Notch repeats of
pregnancy-associated plasma protein-A bind calcium and determine its
proteolytic specificity. Under review 2004.
166. Dosiou C, Hamilton A, Tulac S, Giudice LC. Membrane progesterone
receptors are expressed in peripheral T cells of women. J Clin
Endocrinol Metab. 2004, in preparation.
167. Bhatia S, Faessen GH, Carland G, Balise RL, Gargosky SE, Druzin M,
El-Sayed Y, Wilson DM, Giudice LC. A longitudinal analysis of maternal
serum IGF-I and total and non-phosphorylated IGFBP-1 in human
pregnancies complicated by pre-eclampsia. In preparation.
168. Suh D-S, Giaccia AJ, Giudice LC. Analysis of gene expression in
response to hypoxia in HepG2 human hepatocarcinoma cells using
microarray profiling. In preparation.
169. Popovici RM, Suen L-f, Irwin JC, Giudice LC. Inhibition of decidual
markers by IGF-II is mediated via the Type I IGF receptor. In
preparation.
170. Tulac S, Kao LC, Nayak N, Nusse R, Giudice LC: Progesterone
regulation of DKK-1in human endometrial stromal cells. In preparation.
171. Tulac S, Faessen GF, Nayak N, Nusse R, Giudice LC: Actions of Wnt
on human endometrial stromal cells. In preparation.
172. Kao LC, Gurmeyer A, Tulac S, Nayak N, Giudice LC. Semaphorin and
neuropilin expression in human endometrium. In preparation.
173. Lathi R, Hess, A, Tulac S, Faessen GF, Conti M, Giudice LC: Insulin
regulation of IGFBP-1 in human endometrial stromal cells involves
signaling through the MAP kinase, but not PI3 kinase, pathway. In
preparation.
174. Lu M, Ionel O, Popovici R, Suen L-F, Irwin JC, Giaccia AJ, Giudice
LC. Hypoxia increases IGFBP-3 expression in HeLa cervical cancer cells.
Growth Horm & IGF Res, 2004, submitted.
175. Telles TL, Kao LC, Suh DS, Giudice LC. Cyclooxygenase-1 (COX-1) and
COX-2 expression in human endometrium, in preparation.
176. Tissot van Patot MC, Giudice LC, Moore LG, Young DA, Niccoli SA,
Bhatia S, Faessen GH, Zwerdlinger L, Zamudio S. Steroid hormones and
insulin-like growth factors/binding proteins in maternal serum during
high (3100 m) versus moderate (1600 m) altitude pregnancy, in
preparation.
177. Su, Y-Q, Giudice LC. Gonadotropin, insulin, and PPAR-y agonist
regulation of ovarian granulosa cell steroidogenesis. In preparation.