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As presented under the auspices of the ACOG 53rd Annual Meeting held in San
Francisco, California on May 2005
 Electrical Impedance Scanning: A Novel Technique for Primary Breast Cancer
Screening in Young Women
Alexander Stojadinovic, MD
Walter Reed Army Medical Center
Clinical Breast Care Project
Abstract - ACCEPTED FOR ORAL PRESENTATION
American College of Obstetrics and Gynecology
Annual Meeting, (ACOG) 2005
Proposal Title: A Novel Technique for Primary Breast Cancer Screening
in Young Women
Presenting Author: Alexander Stojadinovic, MD
Walter Reed Army Medical Center
Clinical Breast Care Project
Building 1, Rm 5C27B
6900 Georgia Avenue, NW
Washington, District of Columbia 20307
Keyword Category: Gynecology
Purpose: To evaluate the sensitivity and specificity of Electrical
Impedance Scanning (EIS) in screening young women (age <40) for breast cancer.
Methods: A total of 1,163 women were examined with an electrical
impedance scanning system (T-Scan™), which measures impedance across the breast
in multiple frequencies. A`post-processing algorithm provides a binary
–“suspicious” or “normal” result. To estimate specificity, 601 average-risk
women were examined. To estimate sensitivity, an additional 562 higher risk
women were examined.
Results: Specificity in the average risk group was 96.2 % (23/601). In
the Sensitivity arm, the 562 women were classified into 6 categories: 1= no
suspicious lesion, no imaging performed (N= 253); 2=further imaging, no
abnormalities (N=200); 3= >1 lesions on imaging, no biopsy (N=16); 4= biopsy
confirmed benign lesion, low risk for development of carcinoma (e.g.
fibroadenoma, FCC, N=84); 5=biopsy confirmed benign lesion with high risk for
development of carcinoma (e.g. radial scar, LCIS, atypia, N=6); 6= confirmed
carcinoma (N=3). A positive EIS
result strongly correlated with increasing risk categories being 2.8%, 2.0%,
6.0%, 5.0%, 33.3% and 66.7% respectively, P<0.001.
Discussion: Currently, no reliable breast cancer screening tool exists
for women age <40. Measured sensitivity and specificity in this study indicate
that a T-Scan positive woman is >7 times more likely to have breast cancer than
a woman from the general population. In the Ob/Gyn setting, this exam appears
valuable for the identification of younger women who are at elevated risk for
breast cancer and thus more likely to benefit from earlier, additional breast
imaging (e.g. mammography, ultrasound).
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