OBGYN.net Editorial Advisor
Executive Advisory Board, Infertility

Professor Zeev Shoham (Schwart), MD, - Israel
Professor, Hebrew University, Hadassah Medical School
Director of the Reproductive Medicine Unit
Kaplan Medical Center
Rehovot 76100, Israel
Website: www.ivf-worldwide.com
Articles and Interviews on OBGYN.net by Dr. Shoham

Personal

Date of Birth: 29 April 1951, Jerusalem, Israel
Marital Status: Married with 2 children.
Military Service: 1970-1973

Education

  • 1980 - Medical studies at the Hadassah Medical School Jerusalem
  • 1980 - Internship at Hadassah Medical Center, Jerusalem

Professional Education

  • 1981-1986 - Resident, Kaplan Hospital, Rehovot, Department of Obstetrics and Gynecology
  • 1984-1985 - Research: Hammersmith Hospital, Institute of Obstetrics and Gynecology
  • 1986 - Internship, Institute of Endocrinology, Chaim Sheba Medical Center, Tel-Hashomer, Israel
  • 1986 - Research fellow at the WHO collaborative center for fertility promoting drugs
  • 1986-1987 - IVF clinical and research unit. Chaim Sheba Medical Center, Tel-Hashomer
  • 1989-1991 - Clinical and Laboratory research, Reproductive Endocrinology Unit, Cobbold Laboratories, Middlesex Hospital, London, UK, Under Prof HS Jacobs.
  • From 1991 - Reproductive and Endocrinology Unit, Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel
  • From 1999 - Director, Reproductive and Endocrinology Unit, Kaplan Hospital, Rehovot

Prizes and Awards:

1992 : The ESHRE European Prize for the best Research Study in Europe for the year 1991
Academic Degree at the Hebrew University and Hadassah Medical School, Jerusalem
  • 1988 - Lecturer
  • 1991 - Senior Lecturer
  • 1995 - Associate Professor

Organizer of Local and International Symposium

  • 1993 - "International Symposium on ovarian function and induction of ovulation" July 28-30, 1993, Tel-Aviv, Israel.
  • 1993 - "First Embryology Meeting in Israel" December 3-4, Herzelia, Israel
  • 1994 - "Second Embryology Meeting in Israel" October 21-22, Herzelia, Israel
  • 1995 - "New frontiers in reproductive endocrinology and assisted reproductive technology" July 27, 1995, Tel-Aviv, Israel
  • 1997 - International Symposium "Update in Reproductive Medicine, ART, Preimplantation Diagnosis, Oral Contraception and HRT" Tel-Aviv, Israel, September 11, 1997
  • 1998 - 13th Congress of the European Association of Obstetrics and Gynecology. Jerusalem, Israel, May 11-13
  • 1998 - International Symposium on Reproductive Health and Infertility. London, UK, September 16-17, 1998.
  • 1999 - The First Congress on Controversies in Obstetrics, Gynecology and Infertility, Prague, CZ, October 28-31, 1999

Reviewer

  • 1992 - Ad Hoc Fertility and Sterility
  • 1994 - Ad Hoc Israel J Obstet Gynecol
  • 1994 - Ad Hoc Human Reproduction
  • 1994 - Grants submitted to the Chief Scientist of the Israeli Ministry of Health
  • 1995 - M.D. Thesis, The Hebrew University Hadassah Medical School

Editorial Board Member

  • From 1997: Manage care in practice
  • From 1996: Fertility and Sterility
  • OBGYN.net Executive Advisory Board
  • OBGYN.net Infertility Editorial Advisor
  • OBGYN.net Past Editor for PowerPoint Presentations, 1997-2011

Book Editor

  • Controversies in Obstetrics, Gynecology and Infertility, Manduzzi Publisher, 1999
  • Female infertility therapy: Current practice. Martin Dunitz Publisher, 1998

Grants for International Projects

1990 - Dose response study use of B-hGH for induction of ovulation in In Vitro
Fertilization (GH-V-3-GB-016/ S/GHV)
Novo Nordisk A/S US$ 45,000

1991 - Single dose pharmacokinetics and pharmacodynamics of recombinant human follicle stimulating hormone (Org 32489) in gonadotropin-deficient volunteers.
Organon International BV US$ 27,000

1992 - Single dose pharmacokinetics and pharmacodynamics comparing purified FSH (Metrodin) and recombinant human follicle stimulating hormone.
Organon International BV US$ 20,000

1993 - A randomized, assessor-blind, group comparative multicenter, safety and efficacy study of Org 32489 and Metrodin in women with chronic anovulation (WHO-group II).
Organon International BV US$ 18,000

1994 - A randomized assessor-blind, group comparative multicenter safety and efficacy study of Org 32489 in infertile women treated by in vitro fertilization with Org 32489 or Metrodin, both after pituitary suppression with Buserelin
Organon International BV US$ 57,000

1994 - Determination of the efficacy and safety of recombinant- human LH with recombinant-human FSH in WHO group I anovulatory women
Ares-Serono US$ 21,000

1994 - A randomized, assessor-blind, group comparative multicenter, safety and efficacy study of Org 32489 administered IM vs. SC in women undergoing ovulation induction for IVF-ET.
Organon International BV US$ 17,600

1995 - A multicenter, double-blind, comparative, parallel, dose finding, phase II clinical study to compare the safety and efficacy of (r-hLH, LH Ladi) with urinary hCG for induction final follicular maturation and early luteinization in women undergoing superovulation with r-hFSH (Gonal-F) prior to IVF-ET.
Ares-Serono US$ 20,000

List of Publications

1. Schenker JG, Birkenfield A, Schwartz Z . Endometrial cancer in Israel, 1969 - 1975. Int. J. Gynecol. Obstet. 20: 455-461, 1982

2. Schwartz Z. Dgani R, Lancet M. Uterine sarcoma in Israel. A study of 104 cases. Gynecol. Oncol. 20: 354-363, 1985.

3. Schwartz Z. Ohel G, Anteby J, Schenker JG. Second primary malignancy in endometrial carcinoma patients. Gynecol. Oncol. 22: 40-45, 1985.

4. Schwartz Z, Dgani R, Flugelman MY, Lancet M, Gelerenter I. A novel approach to the analysis of risk factors in endometrial carcinoma. Gynecol. Oncol. 21: 228-234, 1985.

5. Schwartz Z, Katz Z, Lancet M. Management of puerperal separation of the symphysis pubis. Int. J. Gynecol. Obstet. 23: 125-128, 1985.

6. Schwartz Z, Dgani R, Katz Z, Lancet M. Urinary retention caused by impaction of leiomyoma in pregnancy. Acta Obstet. Gynecol. Scand. 65: 525-526, 1986.

7. Schwartz Z, Katz Z, Zosmer A, Dreazen E, Lancet M, Sagiv M. Polyhydramnios caused by giant alveolar granular cell myoblastoma. Acta Obstet. Gynecol. Scand. 65: 519-521, 1986.

8. Katz Z, Schwartz Z, Lancet M. Constant ovulation on the side of an occluded tube treated with Human Menopausal Gonadotropin. Fertil. Steril. 45: 717-718, 1986

9. Schwartz Z, Katz Z, Lancet M, Bernstein D. Tubal pregnancy with patient tube diagnosed by hysterosalpingography. Int. Gynecol. Obstet. 24: 383-384, 1986.

10. Schwartz Z, Dgani R, Lancet M, Kessler I. Face presentation. Australia and NZ. J. Obstet. Gynecol. 26: 172-176, 1986.

11. Kessler I, Lancet M, Schwartz Z, Yamini M, Kassner R. The fate of pregnancy after first and midtrimester bleeding. Harefuah 110: 8-11, 1986. (Hebrew)

12. Ohel G, Schwartz Z, Birkenfield A, Anteby SO, Schenker JG. second primary genital malignancies with endometrial cancer. Arch. of Gynecol. 239: 75-80, 1986.

13. Schwartz Z, Guest JF, Elder MG, White JO. Enzyme activities in the androgenized rat uterus refractory to oestrogenic stimulation J. Steroid. Biochem. 25: 491-496, 1986.

14. Zosmer A, Katz Z, Lancet M, Kunitevsky B, Shoham (Schwartz) Z. Adult respiratory distress syndrome complicating ovarian hyperstimulation syndrome. Fertil. Steril. 47: 524-526, 1987.

15. Megory E, Zuckerman H, Shoham (Schorartz) Z, Lunenfeld B. Infections and male fertility. Obstet. Gynecol. Survey 42: 283-290, 1987.

16. Blickstein I, Shoham (Schwartz) Z, Lancet M, Bornstein R. Vaginal delivery for the second twin in breech presentation. Obstet. Gynecol. 69:774-776, 1987.

17. Blickstein I, Shoham (Schwartz) Z, Lancet M. Predisposing factor in the formation of true knots of the umbilical cord. Analysis of morphometric and prenatal data. Int. J. Gynecol. Obstet. 25:395-398, 1987.

18. Blickstein I, Shoham (Schwartz) Z, Borenstein R, Lancet M. Characterization of the Growth Discordant Twin. Obstet. Gynecol. 70:11-14, 1987.

19. Shoham (Schwartz) Z, Katz E, Blickstein I, Katz Z, Zosmer A, Dgani R, Lancet M. New imunochemical method for rapid detection of Human Chorionic Gonadotropin in urine. Clinical Chemistry. 33:800-805, 1987.

20. Shoham (Schwartz) Z, Lidor A, Megory E, Lunenfeld B, Blankstein J, Weissenberg R. The influence of different copper wires on human sperm penetration into bovine cervical mucus. Contraception 36:327-334, 1987.

21. Shoham (Schwartz) Z, Megory E, Lidor A, Madgar I, Lunenfeld B, Wissenberg R. Effect of washing and suspention on penetration of human sperm into bovine cervical mucus. Arch. Androl. 19:261-267, 1987.

22. Megory E, Shoham (Schwartz) Z, Madgar I, Lunenfeld B, Modan M, Weissenberg R. ATP content in human semen and sperm quality. Arch. Androl. 19:243-247, 1987.

23. Dgani R, Shoham (Schwartz) Z, Czernobilsky B, Kaftori A, Borenstein R, Lancet M. Lactic dehydrogenase, alkaline phosphatse and human chorionic gonadotropin in a pure ovarian dysgerminoma. Gynecol. Oncol. 30:44-50, 1988.

24. Blickstein I, Shoham (Schwartz) Z, Lancet M. The obstetric perspective of neurofibromatosis Am. J. Obstet. Gynecol. 158:385-388, 1988.

25. Dgani R, Rosenman D, Shoham (Schwartz) Z, Lancet M, Nissim F, Pfeffermann R, Levy E, Shani A. Ovarian malignancies in pregnancies complicated by colonic perf oration. Isr J. Med Sci. 24:241-244, 1988.

26. Levran D, Shoham (Scvhwatrz) Z, Netzer N, Serr DM, Mashiach S. Sexual behavior Of Unmarried Tel-Aviv University Students. Sexual and Marital therapy 3:103-109, 1988.

27. Shoham (Schwartz) Z, Caspi B, Chemke J, Dgani R, Lancet M. Iniencephaly : Prenatal ultrasonographic diagnosis: a case report. J. Prenat. Med. 16:139-143, 1988.

28. Katz Z, Shoham (Schwartz) Z, Lancet M, Blickstein I, Mogilner BM, Zalel Y. Managment of labor with umbilical cord prolapse: A 5 year study. Obstet. Gynecol. 72:278-281, 1988.

29. Blickstein I, Shoham (Schwartz) Z, Lancet M. Growth discordancy in appropriate for gestational age, term twins. Obstet. Gynecol. 72:582-584, 1988.

30. Shoham (Schwartz) Z, Yamini M, Barash A, Segal I, Sindel L, Lancet M, Borenstein R. In vitro fertilization and embryo transfer program, at Kaplan Hospital, Rehovot Israel J. In. Vitro. Fert. Embryo. Transf. 5:237-8, 1988.

31. Mashiach S, Dor J, Goldenberg M, Shalev J, Blanckstein J, Rudak E, Shoham (SchwartZ) Z, Finelt Z, Nebel L, Goldeman B, Ben-Rafael Z. Protocols for induction of ovulation; The concept of programmed cycles. Ann N.Y. Acd. Sci. 541:37-45, 1988.

32. Kesler I, Shoham (Schwartz) Z, Lancet M, Blickstein I, Yemini M, Miskin A, Mogilner M. Complications associated with genital colonization in pregnancies with and without cerclage. Int. J. of Gynecol. Obstet. 27:359-363, 1989.

33. Degani R, Shoham (Schwartz) Z, ,Atar E, Zosmer A, Lancet M. Ovarian carcinoma during pregnancy: a study of 23 cases in Israel between the years 1960-1984. Gynecol. Oncol. 33:326-331, 1989.

34. Shoham (Schwartz) Z, Katz Z, Lancet M. Gore-Tex surgical membrane. Fertil. Steril. 51:1071-2,1989.

35. Yemini M Shoham (Schwartz) Z, Degani R, Lancet M, Mogilner BM, Nlsslm F, Bar-Khayim Y. Lupus-like dyndrome in a mother and newborn following administration of hydralazine. fur. Gynecol. Reprod. Biol. 30:193-197, 1989.

36. Yamini M, Shoham (Schwartz) Z, Katz Z, Meshorer A, Borenstein R, Lancet M. Effectiveness of Silicon sheeting in preventing the formation of pelvic adhesions. Int. J. Fertil. 34:71-73, 1989.

37. Levran D, Shoham (Schwartz) Z, Geranek M, Greenwald M, Mashiach S. The value of amnioscopy in surveillance of post-date pregnancy. Aust NZ. J. Obstet. Gynecol. 28:271-274, 1989.

38. Shoham (Schwartz) Z, Lidor A, Lunnenfeld B. The assesment of a cycle with clomiphene as an indicator for further treatment. J. Endocrinol. Invest. 12:9-12, 1989.

39. Dgani R, Shoham (Schwartz) Z, Czernobilsky B, Singer D, Shani A, Lancet M. Endolymphatic stromal myosis (endometrial low grade stromal sarcoma) presenting with hematuria: A diagnostic challenge. Gynecol. Oncol. 35:263-266, 1989.

40. Shoham (Schwartz) Z, Blickstein I, Zosmer A, Katz Z, Borenstein R. Transverse uterine incision for cesarean delivery of the transverse-lying fetus. fur. J. Obstet. Gynecol. Reprod. Biol. 32:67-70, 1989.

41. Zosmer A, Shoham (Schwartz) Z, Dgani R, Ashkenazi M, Levin J, Lancet M. Solitary thick intrauterine membranes not associated with the amniotic band syndrome. fur. J. Obstet. Gynecol. Reprod. Biol. 32:173-178, 1989.

42. Caspi B, Shoham (Schwartz) Z, Barash A, Lancet M. Sonographic demonstration of an intrauterine device perforating into a uterine myoma. JCU 17:535-7, 1989.

43. Borenstein R, Elhalal U, Lunenfeld B, Shoham (Schwartz) Z, Severe ovarian hyperstimulation syndrome: A reevaluated therapeutic approach. Fertil. Steril. 51:791-795, 1989.

44. Borenstein R, Shoham (Schwartz) Z, Premature rupture of membrane in a single twin gestational sac. J. Reprod. Med. 35:270-271, 1989.

45. Barash A, Shoham (Schwartz) Z, Blikstein I, Yamini M, Borenstein R. Simultaneous tubal and intra-uterine pregnancy following in vitro fertiliz ation and embryo transfer. Acta. Obstet. Gynecol. Scand. 68:643-644, 1989.

46. Borenstein R, Shoham (Schwartz) Z, Yemini M, Barash A, Fienstein M, Rozenman D. Tamoxifen treatment in women with failure of clomiphene citrate therapy. Aus. NZ. J. Obstet. Gynecol. 29:173-175, 1989.

47. Barash A, Shoham (Schwartz) Z, Borenstein R, Nebel L Development of human embryos in the presence of copper intrauterine device. Gynecol. Obstet. Invest. 29:203-206, 1990.

48. Shoham Z, Ezri T, Konichezky S, Boksenbojn P, Borenstein R, Soroker D. Ventricular tachycardia associated with injection of prostaglandin F-2 alpha into the uterine cervix during anesthesia. Anesthesiology 2:775-776, 1990.

49. Barash A, Shoham (Schwartz) Z, Lunenfeld B, Segal I, Insler V, Borenstein R. Can premature luteinization in superovulation protocols be prevented by aspiration of an ill-timed leading follicle? Fertil. Steril. 53:865-869, 1990.

50. Shoham (Schwartz) Z, Barash A, Borenstein R. Gamete intrafallopian tube transfer (GIFT): making laparoscopy more than "diagnostic" Fertil. Steril. 53:581-583, 1990.

51. Levran D, Shoham (Schwartz) Z, Habib D, Greenwald M, Nebel L, Mashiach S. Glucose tolerance study in pregnant women following treatment for sterility. Int. J. Fertil. 35:157-159, 1990.

52. Shoham (Schsrartz) Z, Borenstein R, Lunenfeld B, Pariente C. Hormonal profiles following clomiphene citrate therapy in conception and nonconception cycles. Clin. Endocrinol. (Oxf) 33:271-278, 1990.

53. Shoham (Schwartz) Z, Barash A, Yemini M, Borenstein R, Combined diagnostic laparoscopy and follicular aspiration for human in vitro fertiliz ation. Acta. Obstet. Gynecol. Scand. 69:23-26,1990.

54. Dor J, Shalev J, Shoham Z, Rabau M, Rudak E, Serr DM, Mashiach S. In vitro frtilization in Kock' s illeostomy patients. Prior evaluation by pelvic ultrasonography. Gynecol. Obstet. Invest. 29:158-160, 1990.

55. Dgani R, Blickstein I, Shoham Z, Czernobilsy B, Hen Hur H, Shani A, Katz Z, Borenstein R. Clinical aspects of ovarian tumors of low malignant potential. fur. J. Obstet. Gynecol. Reprod. siol. 35:251-258, 1990.

56. Shoham Z, Homburg R, Jacobs HS. Induction of ovulation with pulsatile GnRH. Baillieres. Clin. Obstet. Gynecol. 4:589-608, 1990.

57. Shoham (Schwartz) Z, Zosmer A, Insler V. Early pregnancy loss following induction of ovulation with clomiphene citrate, human menopausal gonadotropin/human chorionic gonadotropin, in vitro fertilization and embryo transfer and gamete intrafallopian transfer. Isr. J. Obstet. Gynecol. 1:93-97, 1990.

58. Atar E, Dgani R, Shoham Z, Borenstein R. Malignant ovarian tumors in pregnancy. Harefuah 119:146-148, 1990 (Hebrew).

59. Rozenman D, Gurewicz S, Blickstein I, Shoham Z, Bar-Khayim Y. Sexual Function of women on dialysis. Dialysis and Transplantation 19:642-644, 1990.

60. Shoham Z, Zosmer A, Insler V. Early miscarriage and fetal malformations after induction of ovulation (by clomiphene citrate and/or human menotropins), in-vitro fertilization and gamemte intrafallopian transfer. Fertil. Steril. 55:1-11, 1991.

61. Shoham Z, Homburg R, Jacobs HS. CV 205-502, effectiveness, tolerability and safety over 24-month study. Fertil. Steril. 55:507-512, 1991.

62. Fenakel K, Fenakel G, Appelman Z, Lurie S, Katz Z, Shoham Z. Nifedipine in the treatment of severe preeclampsia. Obstet. Gynecol. 77:331-337, 1991.

63. Shoham Z, Patel A, Jacobs HS. Polycystic ovary syndrome: safety and effectiveness of stepwise and low dose administration of purified follicle-stimulating hormone. Fertil. Steril. 55:1051, 1991.

64. Jacobs HS, Bouchard P, Conway GS, Homburg R, Lahlou N, Mason B, Ostergaard H, Owen EJ, Shoham Z. Role of growth hormone in infertility. Horm. Res. 36 (Suppl 1):61-5,1991.

65. Shoham Z, Balen A, Patel A, Jacobs HS. Results of ovulation induction using human menopausal gonadotropins or purified follicle-stimulating hormone in hypogonadotropic hypogonadism patients. Fertil. Steril. 56:1048-53,1991.

66. Di Carlo C, Shoham Z, MacDougall J, Patel A, Hall ML, Jacobs HS. Polycystic ovaries as a relative protective factor for bone mineral loss in young women with amenorrhea. Fertil. Steril. 57:314-9, 1991.

67. Owen EJ, Shoham Z, Mason B, Jacobs HS: Cotreatment with growth hormone, following pituitary suppression, for ovarian stimulation in vitro fertilization: a randomized, double-blind, placebo-controlrtail. Fertil. Steril. 56:1104-10, 1991.

68. Shoham Z, DiCarlo C, Patel A, Conway GS, Jacobs HS. It is possible to run a successful ovulation induction program based solely on ultrasound monitoring? The importance of endometrial measurements. Fertil. Steril. 56:836-41, 1992.

69. Shoham Z, Conway G, Ostergaard H, Lahlou N, Bouchard P, Jacobs HS. Cotreatment with growth hormone for induction of spermatogenesis in patients with hypogonadotropic hypogonadism. Fertil. Steril. 57:1044-51, 1992.

70. Shoham Z, Insler V. Ectopic pregnancies after induction of ovulation and in vitro ferti1ization. Fertil. Steril. 57:227, 1992

71. Shoham Z, Coneway G, Patel A, Jacobs HS. Polycystic ovaries in patients with hypogonadotropic hypogonadism: similarity of ovarian response to gonadotropin stimulation in patients with polycystic ovary syndrome. Fertil. Steril. 58:37-45, 1992.

72. Shoham Z, Homburg R, Owen EJ, Conway GS, Ostergaard H, Jacobs HS. The role of treatment with growth hormone in infertile patients. Bailliere's Clin. Obstet. Gynecol. 6:267-82, 1992.

73. Mannaerts B, Shoham Z, Schoot B, Bouchard P, Harlin J, Pauser B, Jacobs HS, Rombout F, Bennink CH. Single-dose pharmacokinetics and pharmacodynamics of recombinent human follicle-stimulating hormone (Org 32489) in gonadotropin deficient volunteers. Fertil. Steril. 59:108-14, 1993.

74. Insler V, Shoham Z, Barash A, Koistinen R, Seppala M, Hen M, Lunenfeld 8, Zadik Z. Polycystic ovaries in lean and obese patients: possible pathophysiological mechanism based on new interpretation of facts and findings. Hum. Reprod. 8:379-84, 1993.

75. Shoham Z, Borenstein R, Barash A, Zalel Y, Insler V. Prevetion of ovarian hyperstimulation? Fertil. Steril. 60:585, 1993.

76. Shoham Z, Jacobs HS, Insler V. Luteinizing hormone: its role, mechanism of action and its detrimental effects when hypersecreted during the follicular phase. Fertil. Steril. 59:1153-65, 1993.

77. Shoham Z, Jacobs HS. Fatal attraction. Fertil. Steril. 59:1140, 1993

78. Shoham Z, Mannaerets B, Insler V, Coelingh-Bennink H. Induction of follicular growth using recombinant human follicle-stimulating hormone in two volunteer women with hypogonadotropic hypogonadism. Fertil. Steril. 59:738-42,1993.

79. Weissman A, Shoham Z, Favorable pregnancy outcome after administration of a long-acting GnRH-analog in the midluteal phase. Hum. Reprod. 8:496-7, 1993.

80. Insler V, Barash A, Shoham Z, Koistienen R, Seppala M, Hen M, Lunenfeld B, Zadik Z. Overnight secretion pattern of growth hormone, sex hormone-binding globulin, insulin-like growth factor-i and its binding protein in obese and non-obese women with polycystic ovarian disease. Isr. J. of Med. Sci. 30:42-47, 1994.

81. Luria S, Katz Z, Yehazkeli Y, Lifshitz R, Shoham Z. Microscopic salpingitis is not the etiologic factor of tubal pregnancy with intrauterine device. Int. J. Fertil. 39:333-336, 1994.

82. Schacter M, Shoham Z, Amenorrhea during the reproductive years - is it safel Fertil. Steril. 62:1-16, 1994.

83. Shoham Z, Howles CM, Zalel Y, Weissman A, Insler V. Induction of follicular growth and production of a normal hormonal milieu in spite of using a constant low dose of LH in women with hypogonadotropic hypogonadism. Hum. Reprod. 9:431-436, 1994.

84. Dgani R, Zalel Y, Biran H, Blickstein I, Caspi B, Weissman A, Shoham Z. Successful resolution of persistent trophoblastic disease after partial mole with EMA-CO regimen. Fur. J. Obstet. Gynecol. Reprod siol 54:77-9, 1994.

85. Shoham Z, Zalel Y, Jacobs HS. The role of growth hormone in male infertility. Clin Endocrinol (Oxf) 41:1-5,1994.

86. Scoot D, Harlin J, Shoham Z, Mannaerts MJL, Lahlou N, Bouchard P, Coelingh-Bennink HJT, Fauser BCJM. Human recombinant follicle-stimulat ing hormone and ovarian response in gonadotropin deficient women. Hum. Reprod. 1994;9:1237-42.

87. Shoham Z, Weissman A, Barash A, Borenstein R, Schachter M, Insler V. Intravenous albumin for the prevention of severe ovarian hyperstimulation syndrome in an in vitro fertilization program: a prospective, randomized, placebo-controlled study. Fertil. Steril. 62:137-42, 1994.

88. Shoham Z, Epidemiology, etiology, and fertility drugs in ovarian epithelial carcinoma: Where are we today? Fertil. Steril. 1994;62:433-48.

89. Jaffa AJ, Weissman A, Har-Toov J, Shoham Z, Peyser RM. Flow velocity waveforms of the uterine artery in pregnancy: transvaginal versus transabdominal approach. Gynecol. Obstet. Invest. 1995;40:80-83

90. European and Australian Multicenter Study. Go-treatment with growth hormone and gonadotrophin for induction of ovulation in hypogonadotrophic patients: a prospective, randomized, placebo-controlled, dose-response study. Fertil Steril 1995;64:917-23.

91. Luria S, Shoham Z. Induced midtrimester abortion and future fertility - where are we today. Int J Fertil 1995;40:311-315.

92. The European Puregon Collaborative IVF Study Group. A prospective, randomized assessor-blind, multicenter study comparing recombinant and urinary follicle-stimulating hormone (Puregon vs Metrodin) in in-vitro fertilization. Hum Reprod 1995;10:2534-2540.

93. Shoham Z, Schachter M, Loumaye E, Weissman A, MacNamee M, Insler V. The LH surge the final stage in ovulation induction: modern aspects of ovulation triggering. Fertil Steril 1995;64:237-251.

94. Shoham Z. Oocyte donation by a daughter: Clinician's views worldwide. Hum Reprod 1995;10:1334-1335.

95. Weissman A, Loumaye E, Shoham Z. Recovery of corpus luteum function after prolonged deprivation from gonadotrophin stimulation. Hum Reprod 1996;11:943-949.

96. Mannaerts B, Fauser B, Lahlou N, Harlin J, Shoham Z, Coelingh Bennink H, Bouchard P. Serum hormone concentrations during treatment with multiple rising doses of recombinant follicle stimulation hormone (Puregon) in men with hypogonadotropic hypogonadism. Fertil Steril 1996;65:406-410.

97. Zalel Y, Manor M, Zadik Z, Shoham Z. Successful induction of spermatogenesis in a patient with hypogonadotropic hypogonadism following co-treatment with growth hormone. Gynecol Endocrinol 1996;10:29-31.

98. Zalel Y, Draysen R, Goldschmit R, Zadik Z, Shoham Z. A prospective pilot study of co-treatment with growth hormone and gonadotropins for improving spermatogenesis in normogonadotropic patients with severe oligoteratoasthenospermia. Gynecol Endocrinol 1996;10:23-28.

99. Shoham Z, Jacobs H.S. Value of growth hormone in ovulation induction? Fertil Steril 1996;6:1260-1261.

100. Weissman A, Shoham Z. Doppler and luteal phase defect. Fertil Sterili 1996;66:166.

101. Wissman A. Luria S, Zalel Y, Goldchmit R. Shoham Z. Human chorionic gonadotropin: pharmacolinetics of subcutaneous administration. Gynecol Endocrinol 1996;10:273-276.

102. Shoham Z, Schachter M. Estrogen biosynthesis-regulation action, remote effects, and value of monitoring in ovarian stimulation cycles. Fertil Steril 1996;65:687-701.

103. Shoham Z, Insler V. Recombinant technique and gonadotropins production: new era in reproductive medicine. Fertil Steril 1996;66:187-201.

104. Ben-Arie A, Weissman A, Shoham Z. Triggering the final stage of ovulation using gonadotropin-releasing hormone nanalogues: effective dose, prevention of ovarian hyperstimulation syndrome and the luteal phase. Hum Reprod 1996;11:1146-1147.

105. Shoham Z. Ovulation induction - from theory to practice. Israel J Obstet Gynecol 1996:7;170-87.

106. Shoham Z. Prophylactic oophorectomy: Should prophylactic oophorectomy be performed on post-menopausal women undergoing laparotomy or laparoscopy for non-gynecological indications? Hum Reprod 1977;12:201-202.

107. Caspi B, Appelman Z, Rabinerson D, Zalel Y, Tulandi T, Shoham Z. The growth pattern of ovarian dermopid cysts: a prospective study in premenopausal and postmenopausal women. Fertil Steril 1997:68;501-5.

108. Luria S. Rabinerson D, Shoham Z. The veracious etiology of ectopic pregnancy. Acta Obstet Gynecol Scand 1998;77:120-121.

109. Barash A, Weissman A, Manor M, Milman D, Ben-Arie A, Shoham Z. Prospective evaluation of endometrial thickness as a predictor of pituitary down-regulation following GnRH-a administration in an IVF program. Fertil Steril 1998;69:496-9.

110. Recombinant Human LH Study Group. Recombinant human luteinizing hormone (r-hLH) to support recombinant human follicle stimulating hormone (r-FSH)-induced follicular development in LH and FSH deficient anovulatory women: a dose-finding study. J Clin Endoc Metabol 1998:83;1507-14.

111. Weissman A, Barash A, Manor M, Ben-Arie A, Granot I, Shoham Z. Acute changes in endometrial thickness following aspiration of functional ovarian cysts. Fertil Steril 1998:69;1142-4.

112. Granot I, Dekel N, Segal I, Fieldust S, Shoham Z, Barash A. Is hydrosalpinx fluid cytotoxic? Hum Reprod 1998; 13:1620-1624.

113. Zung A, Shoham Z, Open M, Altman Y, Dgani R, Zadik Z. Sertoli cell tumor causing precocious puberty in a girl with Peutz-Jeghers Syndrome. Gynecol Oncol 1998:70;421-4.

114. Caspi B, Weissman A, Zalel Y, Barash A, Tulandi T, Shoham Z. Ovarian stimulation and in vitro fertilization in women with mature cystic teratomas. Obstet Gynecol 1998:92;979-81.

115. Goshen R, Weissman A, Shoham Z. Epithelial ovarian cancer: infertility and induction of ovulation: possible pathogenesis and updated concenpts. Baillier's Clinical Obstetrics and Gynecology 1998:14;581-91.

Abstracts (Paper Publications)

1. Shoham (Schwartz) Z, Lunenfeld B. Ovulation Induction with Clomiphene citrate: A reassessment. Gynecological Endocrinol vol 3, Supp 1, 135 S 1989.

2. Owen E, Shoham Z, Mason B, Jacobs HS. Combined treatment of human growth hormone and gonadotrophins in hypogonadotrophic hypogonadism patients, previously resistant to treatment, in order to induce spermatogenesis. Gynecol. Endocrinol. (Supp.) 4: 106, 1990.

3. Shoham Z, Ostergaard H, Bouchard P, Jacobs HS: Combined treatment of human growth hormone and gonadotrophins in hypogonadotrophic hypogonadism patients, previously resistant to treatment, in order to induce spermatogenesis. Endocrinol. (Supp.) 127:106, 1990.

4. Shoham Z, Homburg R, Jacobs HS. CV 205-502, effectiveness, tolerability and safety over 24-month study. Gynecol. Endocrinol. 5:316, 1991.

5. Di Carlo C, Shoham Z, Patel A, Conway GS, Nappi C. Monitoring ovarian stimulation by ultrasound. The importance of the endometrial measurements. Gynecol. Endocrinol. 5:405,1991.

6. Shoham Z, Patel A, Di Carlo C, Conway GS, Jacobs HS. Is it Possible to run a successful ovulation induction program based solely on ultrasound monitoring? the role of the endometrium in pregnancy prediction in the mid-luteal phase. Fertil. Steril. 5116:157, 1991.

7. Shoham Z, Patel A, Jacobs HS. Polycystic ovarian syndrome: safety and effectiveness of step-wise and low dose administration of purifies follicle-stimulation hormone. Hum. Reprod. 5:S1:162, 1991.

8. Di Carlo C, Shoham Z, Patel A, Conway GS, Nappi c, Jacobs HS. Monitoring ovarian stimulation by ultrasound. The importance of endometrial measurement. Hum. Reprod. 5:51:209, 1991.

9. Schachter M, Barash A, Shoham Z, Borenstein R, Dekel N. In vitro evidence for the existence of a luteinizing-hormone surge inhibiting factor in human serum. Hum Reprod. 6:51:189, 1992.

10. Borenstein R, Shoham Z, Barash A, Weissman A, Zalel Y, Insler V. Intravenous albumin administration - a novel approach for the prevention of severe ovarian hyperstimulation syndrome. Hum. Reprod. 8:51:32, 1993.

11. Harlin J, Schoot DC, Mannaerts BMJL, Shoham Z, Bouchard P, Coelingh Bennink HJT, Fauser BCJM. Pharmacodynamics and pharmacokinetics of recombinant human FSH in female volunteer with gonadotropin deficiency. Hum Reprod 8:51:140, 1993.

12. Shoham Z, Mannaerts B, Insler V, Goelingh Bennink H. Induction of follicular growth using recombinant human FSH in hypogonadotropic women. Hum. Reprod. 8:S1:148, 1993.

13. Shoham Z. Go-treatment with growth hormone and gonadotrophin for the induction of ovulation in hypogonadotrophic patients: a prospective, randomized, place be-con trolled, dose-response study. Hum. Reprod. 1994.

Chapters in Books

1. Lancet M. Kessler I. Miskin A. Scharartz Z. Dreasen E. Prenatal infectious morbidity after cervical cerclage Antibiotic prophylaxsis. The intra uterine life management and therapy, Schenker J.G. and Wienstein D., editors, Elsevier Science Publishers B.V. p.136-139, 1986.

2. Lancet M. Blikstein I. Shoham (Schwartz) Z, Endoscopy in Gynecology. In: The family physician; Advances in Fertility and Gynecology. 16:275-84, 1989 (Hebrew).

3. Shoham (Schsrartz) Z, Barash A, Lunenfeld B, Segal I, Sindel L, Borenstein R. Prevention of unwanted LH surge by aspiration of the leading follicle in an IVF-ET program. In: Follicular development and the ovulation response, Eds: A. Tsafriri N. Dekel. Serono Symposia Review No. 23 p 301- 306, 1990.

4. Homburg R, Shoham Z, Jacobs HS: Clinical aspects of female hyperprolactinemia: treatment with CV 205-502 compared with bromocr iptine. In:Progress in prolactin-lowering therapy. Edited by R. Pepprell, PG. Corsignani and S. Franks. The Pathenon Publishing Group, New Jersy, USA, p 19-35, 1991.

5. Balen A, Shoham Z, Jacobs HS. Amenorrhea-cause and consequences. In: Studd JJW and Asch R (eds) Annual Progress in Reproductive Medicine. Parthenon Press, Carnforth, 205-234, 1993.

6. Shoham Z. Low-dose protocol of follicle-stimulating hormone for induction of ovulation in patients with polycystic ovary syndrome: The hypothesis, etiology and clinical experience. In: Lunenfeld B. (editor) FSH alone in ovulation induction. Pathenon Publishing Group, New Jersy, USA, p. 29-44, 1993.

7. Shoham Z. The detrimental effects of high LH levels during the follicular phase. The use of purified FSH for ovulation induction. In: Neuroendocrinology of Female Reproductive Function. U. Montemagno, C. Nappi, F. Petralgia, AR. Genazzani (eds) p. 345-357, 1993.

8. Schachter M, Shoham Z. The use of growth hormone for induction of ovulation. In: Neuroendocrinology of Female Reproductive Function. U. Montemagno, C. Nappi, F. Petralgia, AR. Genazzani (eds) p. 261-271, 1993.

9. Coelingh Bennink HJT, Bouchard P, Devroey P, Fauser BCJM,
Harlin J, Shoham Z. Potential clinical applications of recombinant FSH. In Ovulation induction: Basic science and clinical advances. M Filicori, C Flamigni (eds) . Exerpta Medical International Congress Series 1046. Elsivier Science Publishers BV, Amterdam, The Netherlands p. 219-25.

10. Shoham Z. Experimental experience in male infertility. In: Growth Hormone Therapy: New Directions. J and J Verlag GmbH, 1995 p. 123-142.

11. Shoham Z. Role of LH in oocyte maturation. In: Recent Development in Gynecology and Obstetrics. A.R. Genazzani, Petraglia F, D'Ambrogio G, Genazzani A.D. Artini P.G. (eds) The Parthenon Publishing Group, London 1995.

12. Weissman A, Barash A, Shoham Z. Complications of ovulation induction in PCO. In: The ovary: Regulation dysfunction and treatment, M. Filicori, C. Flamigni (eds) Excerpta Medica, International Congress Series 1106, Elsevier, New-York, 1996 p. 425-436.

13. Shoham Z, Weissman Ariel. Etiology: The ovarian hypothesis. In: Endocrine Updates: Polycystic Ovary Syndrome, Eli Y. Adashi Editor. Kluer Academic Publishers, 1998 (In press).

14. Shoham Z, Weissman A. Polycystic ovarian disease: Obesity and insluin resistance. In: Fertility and Reproductive Medicine. R.D. Kempers, J. Cohen, A.F. Haney and J.B. Younger Editors. Expecta Medica, International Congress Series 1183, Elsiver New York 1998, p. 263-73

15. Shoham Z. Effects of different menotropin preparations for ovulation induction in hypogonadotropic women. In: The role of luteinizing hormone in folliculogenesis and ovulation induction. Filicori and C. Flamingi. Editors, Monduzzi Editore 1999, p. 105-14

16. Shoham Z, Weissman A. Ovarian hyperstimulation syndrome.

Lectures at International Meetings
Invited Speaker

1. Low-dose administration of FSH - Third World Congress of Gynecologocal Endocrinology at Madona di Camiglio, Italy, 9-16 February,l992

2. The role of LH in follicular phase, the deremental effects of hypesecretion of LH, induction of ovulation using the low-dose FSH in PCOS patients. - Diamond Institute for Reproduction, Newjersy USA, 14 April, 1992

3. Go-treatment of human growth hormone with gonadotropins in order to induce spermatogenesis in hypogonadotropic hypogonadism previously resistant to treatment. - 40th anual meeting of the Pacific Coast Fertility Society, Palm Springs, Indian Weels, CA, USA, April 8-12, 1992

4. The use of growth hormone in ovulation induction Second International Capri Conference. Neuroendocrine and peripheral disorders of female reproductive system: pathophysiology and therapies. - Capri, Italy, May 22-26, 1992

5. The detrimental effects of high LH levels during the follicular phase. The use of purified FSH for ovulation induction - Second International Capri Conference. Neuroendocrine and peripheral disorders of female reproductive system: pathophysiology and therapies. Capri, Italy, May 22-26, 1992

6. The role of LH in the follicular phase, the detrimental effects of hypersecretion of LH and the induction of ovulation in PCOS patients using purified FSH in a low-dose protocol - Seminar on Infertility New Delhi, India, June 25, 1992

7. Induction of ovulation and induction of spermatogenesis using co-treatment with growth hormone and gonadotropins Symposium on new strategic in ovulation induction. Taipei, Taiwan, June 21, 1992

8. The changing roles of FSH and LH - University of Alabama, Department of Obstetrics and Gynecology, October 28, 1992

9. Deterimental effects of high LH in selected patients on clomiphen - Reproductive Biology Associate, Atlanta University and School of Medicine, Northside Hospital, Atlanta, Georgia, October 28, 1992

10. The role of LH in the induction of ovulation: How much is enough? - 48th Annual Meeting of the American Fertility Society, New Orleans, Louisiana 1992

11. Why add LH, is LH detrimental? - Critical assessment of FSH and LH in follicular development: an international conference. San Francisco, February 13-17, 1993

12. A novel approach for the prevention of the development of severe ovarian hyperstimulation syndrome a prospective, randomized, controlled study. - A National Conference, Korea, Seoul, May 17, 1993

13. Changing role of LH in stimulation protocol - Indian Academy of Human Reproduction, Indian New Delhi, September 17, 1993

14. The changing perspective of LH in the stimulation protocol - Emery University School of Medicine, Atlanta, Georgia, U.S.A. January 19, 1994

15. The role of LH in the follicular phase and its detrimental effect when hypersecreted - Medical College of Georgia, Augusta, U.S.A. January 19, 1994

16. LH, mechanism of action - Ottawa Civic Hospital, Ottawa, Canada, January 25, 1994

17. The changing role of LH for induction of ovulation - Royal Victoria Hospital, McGill University, Montreal, Canada, January 26, 1994

18. Experimental experiences in male infertility - Workshop on the use of growth hormone in future indications. Davos, Switzerland, March 17-19, 1994

19. Ovarian hyperstimulation syndrome. Prevention by albumin transfusion - International Symposium on Frontiers in Reproductive Medicine and Assisted Reproductive Technology. London June 9-11, 1994

20. The detrimental effects of LH in the folliculogenic micro-environment - Century City Hospital, Los Angeles, August 11, 1994

21. The role of GH in male and female infertility - UCSF, San Francisco, August 16, 1994

22. Luteinizing hormone and reproduction: changing perspective - International Conference on Recent Advances in Reproductive Endocrinology Antalya, Turkey, October 9-12, 1994

23. Growth hormone in male and female reproduction - International Conference on Recent Advances in Reproductive Endocrinology Antalya, Turkey, October 9-12, 1994

24. Growth hormone in male and female reproduction - International Conference on Recent Advances in Reproductive Endocrinology Antalya, Turkey, October 9-12, 1994

25. Role of LH in oocyte maturation - 4th World Congress of Gynecologocal Endocrinology and the 2nd Congress of the European Society for Gynecologic and Obstetrics Investigation Madona di Camiglio, Italy, 12-19 February, 1995

26. Amenorrhea during the reproductive years - Advances in Reproductive Endocrinology and Infertility, The Canadian Fertility and Andrology Society, Quebec, Canada, September 20-23, 1995

27. Recombinant drugs: A new era in reproductive endocrinology - Advances in Reproductive Endocrinology and Infertility, The Canadian Fertility and Andrology Society, Quebec, Canada, September 20-23, 1995

28. In vivo growth and maturation: Relative roles of FSH and LH - Life cycle of ovarian follicle, Fort Lauderdale, Florida USA, November 2-5, 1995

29. Does estradiol act as a local regulator of follicular growth and development: clinical implications? - Gonal-F Launch-Meeting, Gstaad, Swetzerland, January 19-21, 1996

30. Complications of ovulation induction in PCO - The ovary: Regulation, Dysfunction and Treatment, Marco Island, Florida, USA, January 25-27, 1996

31. The role of GnRH analogue agonists in assisted reproduction - 4th International Symposium on GnRH analogues in Cancer and Human Reproduction, Geneva, Switzerland, February 8-11, 1996

32. Critical evaluation of ovulation induction methods - Endometriosis and Infertility Symposium, Tokyu, Japan, May 12-16, 1996

33. Use of GnRH analogs in IVF - 1st International Gynecology and Obstetrics Congress, Antalya, Turkey 2-6 June 1996

34. Critical evaluation of ovulation induction methods - 44th Annual Meeting of the Pacific Coast Fertility Society, Indiana
Wells, California, USA, April 17-21, 1996

35. Ovulation induction: Strategies for the future - 44th Annual Meeting of the Pacific Coast Fertility Society, Indiana Wells, California, USA, April 17-21, 1996

36. Current and future modalities in infertility - Cycle Meeting, Chamonix France January 13-17, 1997

37. Clinical experience with recombinant human FSH - 7th Panhellenic Congress on Gynecology and Obstetrics, Crere, Greece, May 14-17, 1997

38. Recombinant LH - 2nd McGill International Symposium, Montreat, Canada, May 22-23, 1997

39. The use of albumin prevents development of severe OHSS - 10th World Congress on In Vitro Fertilization and Assisted Reproduction, Vancouver, Canada, May 24-28, 1997

40. Monocomponent therapy with rec-gonadotropins: is there a future for LH? - 10th World Congress on In Vitro Fertilization and Assisted Reproduction, Vancouver, Canada, May 24-28, 1997

41. Recombinant gonadotropin: Clinical experience - Colombia University, New-York, July 31, 1997

42. Gonadotropin therapy with recombinant technology - The Cleveland Clinic Foundation, Ohio , August 10, 1996

43. The role of LH in follicular development - 4th International Congress of Obstetrics and Gynecology, Izmir, Turkey, September 1-5, 1997

44. Hyperstimulation: prevention and treatment - 4th International Congress of Obstetrics and Gynecology, Izmir, Turkey, September 1-5, 1997

45. Monitoring - Annual ESHRE, Winter Training Course in Reproductive Endocrinology, Barcelona Spain, February 6-7, 1998

46. The role of LH in follicular development - 7th Annual Meeting of the International Society for Gynecologic Endoscopy. Sun City, South Africa March 15-18, 1998

47. Polycystic ovary: Obesity and hyperinsulinism - 16th World Congress on Fertility and Sterility. 54th Annual Meeting of the American Society for Reproductive Medicine. San Francisco, California USA, October 4-9, 1998

48. Effects of different menotropin preparations for ovulation induction in hypogonadotropic women. - The role of LH in folliculogenesis and ovulation induction. Bologna, Italy, October 30-31, 1998

49. Prevention of ovarian hyperstimulation - 12th Congress of the Israel Society of Obstetrics and Gynecology. Haifa, Israel, January 13-14, ?1999.

50. Severe ovarian hyperstimulation syndrome. - The 4th Congress of the European Society for Gynecologic and Obstetric Investigation. Madonna Di Campiglio, Italy, March, 14-19, 1999

51. Use of rec-LH to facilitate monofollicular development - IVF Congress, Sydney, Australia, May 10-15, 1999