Curriculum Vitae
Associate Professor - Adjunct, Yale University School of Medicine
Department of Obstetrics and Gynecology

IVF Medical Director, Reproductive Associates of Delaware
4735 Ogletown-Stanton Road
MAP 2, Suite 3217
Newark, DE 19713
302-623-4242
fax 302-623-4241

Board Certified, Reproductive Endocrinology and Infertility, American
Board of Obstetrics and Gynecology

Name:
Ronald F. Feinberg, M.D., Ph.D.

Faculty Appointment:
Associate Professor - Adjunct, Yale University School of Medicine,
Department of Obstetrics and Gynecology

School Assignment:
School of Medicine

Born:
July 28, 1957; Philadelphia, PA

Education:
1974-77 LaSalle College
Philadelphia, PA
B.A. Maxima Cum Laude, Biology

1977-83 University of Pennsylvania Medical Center Philadelphia, PA
M.D. awarded concomitantly with Ph.D. in Biochemistry

Career:
1983-84 Intern, Obstetrics and Gynecology
Yale-New Haven Hospital, New Haven, CT

1984-87 Resident, Obstetrics and Gynecology
Yale-New Haven Hospital, New Haven, CT

1994-95 Fellow, Reproductive Endocrinology and Infertility
University of Pennsylvania Medical Center, Philadelphia, PA

Assistant Professor, Standing Faculty
Department of Obstetrics and Gynecology
University of Pennsylvania Medical Center, Philadelphia, PA

Attending Staff Physician
Department of Obstetrics and Gynecology
University of Pennsylvania Medical Center, Philadelphia, PA

1995-97 Director, Pregnancy Loss Evaluation Program
Division of Human Reproduction
Department of Obstetrics and Gynecology
University of Pennsylvania Medical Center, Philadelphia, PA

Assistant Clinical Professor
Department of Obstetrics and Gynecology
Yale University School of Medicine, New Haven, CT

Attending Staff Physician
Department of Obstetrics and Gynecology
Christiana Care Health System, Newark, DE

1997- Medical Director, In Vitro Fertilization (IVF) Program
Reproductive Associates of Delaware
Wilmington, DE

Professional Honors or Recognition:
Awarded 5 U.S. Patent Inventions, with Dr. Harvey Kliman as Co-Inventor:

Patent No. 5,276,017: "Therapeutic and diagnostic applications of tropho-uteronectin (TUN) manipulation" Awarded January 4, 1994.

Patent No. 5,395,825: "Fertility regulation with transforming growth factor beta (TGFß)" Awarded March 7, 1995.

Patent No. 5,523,229: "Antibodies specific for oncofetal fibronectin" Awarded June 4, 1996.

Patent No. 5,599,680: "Diagnostic applications of mouse ascites golgi (MAG) manipulation" Awarded February 4, 1997.

Patent No. 5,693,479: "Fertility determination with transforming growth factor beta (TGFß)" Awarded December 2, 1997.

Grants (All as Principal Investigator):
1994-99 National Institute of Health 1R29HD29729: "Tropho-uteronectin (TUN) Function and Regulation"; IRG recommended full 5 year funding of $572,250 ($70,000 direct costs/year; 50% effort)

1994-95 University of Pennsylvania Research Foundation: "Oncofetal Fibronectin and Ovarian Cancer" ($25,000 awarded in direct costs; one year grant)

1993-94 Adeza Biomedical Sponsored Research and Patent Licensing Agreement with University of PA: "Human Trophoblasts and Characterization of Trophoblast Fibronectin (TUN)" ($63,300 awarded in direct costs; one year grant)

1991-93 March of Dimes Basic Research Grant #91-0163: "Human Trophoblast-Extracellular Matrix Interactions" ($60,000 awarded in direct costs; two year grant)

1991-92 Ares-Serono Sponsored Research Agreement: "Tropho-uteronectin (TUN) Purification and Characterization" ($50,000 awarded in direct costs; one year grant)

1991-92 University of Pennsylvania Research Foundation: "Tropho-uteronectin (TUN) and Normal Pregnancy Implantation" ($18,000 awarded in direct costs; one year grant)

1990-91 University of Pennsylvania Research Foundation and Biomedical Research Support Grant: "Is Oncofetal Fibronectin a Trophoblast "Glue" for Normal Human Implantation?" ($17,000 awarded in direct costs; one year grant)

1988-91 March of Dimes Basil O'Connor Award #5-672: "Human Trophoblast Regulation of Plasminogen Activators and Plasminogen Activator Inhibitors: A Potential Role in Abnormal Pregnancy States." ($70,000 awarded in direct costs; two year grant)

Professional Service:
Fellow, American College of Obstetricians and Gynecologists

Member, American Society for Reproductive Medicine

Associate Member, Society for Gynecologic Investigation

Ad hoc reviewer, Reproductive Biology Study Section, National Institutes of Health

Bibliography:

Original Articles
Brodsky L.H., Feinberg R.F., Sorof S. (1978) "Carcinogen-protein complexes in hamster colon and glandular stomach during long-term administration of 3-methylcholanthrene," Cancer Research 38: 1654-1660.

Feinberg R.F., Sun L.K., Ordahl C.P., Frankel F.R. (1983) "Identification of glucocorticoid-induced genes in rat hepatoma cells by isolation of cloned cDNA sequences," Proc. Natl. Acad. Sci. USA. 80: 5042-5046.

Lockwood C.J., Romero R., Feinberg R.F., Clyne L.P., Coster B., Hobbins J.C. (1989) "The Prevalence and Biological Significance of Lupus Anticoagulant and Anticardiolipin Antibodies in a General Obstetrics Population," Am. Journal of Obstetrics and Gynecology 161:369-373.

Feinberg R.F., Kao L.-C., Haimowitz J.E., Queenan J.T., Wun T.-C., Strauss J.F.III, Kliman, H.J. (1989): "Plasminogen Activator Inhibitors Types 1 and 2 in Human Trophoblasts: PAI-1 is a Marker of Invading Trophoblasts," Lab.Invest. 61:20-26.

Kliman H.J , Feinberg R.F., Haimowitz J.E. (1990) "Interactions between human trophoblasts & endometrium in an in vitro suspension culture system," Placenta 11:349-67

Kliman H.J. and Feinberg R.F. (1990) "Human trophoblast-extracellular matrix (ecm) interactions in vitro: ecm thickness modulates morphology and proteolytic activity," Proc. Natl. Acad. Sci. USA 87: 3057-3061.

Kliman H.J., Feinberg, R.F., Haimowitz J.E. (1990) " Interactions between human term trophoblasts and endometrium in vitro," Colloques INSERM 199: 3-9.

Feinberg R.F., Kliman H.J. and Cohen A.W. (1991) "Pre-eclampsia, trisomy 13, and the placental bed," Obstetrics and Gynecology 78: 505-508.

Feinberg R.F., Kliman H.J. and Lockwood C.J. (1991) "Is oncofetal fibronectin a trophoblast glue for human implantation?" American Journal of Pathology 138: 537-543. Cited in 1992 Yearbook of Obstetrics and Gynecology.

Feinberg R.F. and Kliman H.J. (1992) "‘Fetal’ fibronectin and preterm labor" Published letter to the editor. New England Journal of Medicine: 326 (Mar 5): 708.

Feinberg R.F. and Kliman, H.J. (1993) "Tropho-uteronectin (TUN): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblasts" Trophoblast Research 7: 167-179.

Feinberg R.F., Kliman H.J., Wang C.-L. (1994) "Transforming growth factor beta (TGFß) stimulates trophoblast oncofetal fibronectin synthesis in vitro: Implications for trophoblast implantation in vivo" Journal of Clinical Endocrinology &Metabolism 78: 1241-1248.

Feinberg R.F. and Wang C.-L. (1994) "Monoclonal antibody FDC-6 exhibits binding to human plasma fibronectin: A caveat for cervicovaginal oncofetal fibronectin testing?"Am. Journal of Obstetrics and Gynecology 171: 1302-1309. Cited in 1995 Yearbook of Obstetrics and Gynecology.

Feinberg R.F., Kliman H.J., Bedian V., Monzon-Bordonaba, F., Menzin A., Wang C.-L. (1995) "Monoclonal antibody X18A4 identifies an oncofetal fibronectin epitope distinct from the FDC-6 binding site"Am. Journal of Obstetrics and Gynecology 172: 1526-36.

Kliman H.J., Feinberg R.F., Schwartz L.B., Feinman M.A., Lavi E., Meaddough, E.L. (1995) "A human endometrial mucin identified by MAG (mouse ascites Golgi) antibodies: menstrual cycle-dependent localization suggests a link to early implantation events." Am. Journal of Pathology, 146: 166-181.

Feinberg R.F. (1995) "First-trimester versus term trophoblast cultures: Can we learn about implantation from both?" Published letter to the editor. Am. Journal of Obstetrics and Gynecology 172: 1939.
Turpeenniemi-Hujanen T., Feinberg R.F., Kauppila A., Puistola U. (1995) "Extracellular matrix interactions in early human embryos: Implications for normal implantation events." Fertility and Sterility 64: 132-138.

Nachtigall M.J., Kliman H.J., Feinberg R.F., Olive D.L., Engin O., Arici A. (1996) "The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: A potential role in human implantation." Journal of Clinical Endocrinology & Metabolism 81: 801-806.

Monzon-Bordonaba, F., Wang, C.-L., Feinberg R.F. (1997) "‘Fibronectinase’ activity in cultured human trophoblasts is mediated by urokinase-type plasminogen activator." Am. Journal of Obstetrics and Gynecology 176:58-65.

Sawin S.W., Loret de Mola J. R., Monzon-Bordonaba F., Wang C.-L., Feinberg R.F. (1997) "Hydrosalpinx fluid stimulates trophoblast oncofetal fibronectin production: implications for embryonic implantation in assisted reproduction." Fertility and Sterility 68: 65-71.

Menzin A.W., Loret de Mola, J.R., Bilker W.B., Wheeler J.E., Rubin S.C., Feinberg R.F. (1998) "Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer: detection in ascitic fluid and localization to primary sites and metastatic implants." Cancer 82: 152-158.

Bell K.A., Van Deerlin P., Haddad B., Feinberg R.F. (1999) "The cytogenetic diagnosis of a normal 46,XX karyotype in spontaneous abortion specimens is frequently incorrect." Fertility and Sterility, in press.

Case Reports
Feinberg R.F., Lockwood C.J., Salafia C., Hobbins J.C. (1988) "Sonographic Diagnosis of a Pregnancy with a Diffuse Hydatidiform Mole and Coexistent 46,XX Fetus," Obstetrics and Gynecology 72: 485-488.

Review Papers and Chapters

Coutifaris C., Babalola G.O., Feinberg R.F., Kao L.-C., Kliman H.J., Strauss J.F. III. Purified human cytotrophoblasts: Surrogates for the blastocysts in in vitro models of implantation. In: Proceedings of the VI World Congress on In Vitro Fertilization and Alternate Assisted Reproduction, Z. Ben-Rafael and N. Laufer (Eds.), Plenum Publishing Co, New York, 1989.

Kliman H.J., Coutifaris C., Babalola G.O., Soto E.A., Kao L.-C., Queenan J.T., Feinberg R.F., Strauss J.F. III. (1989) "The human trophoblast: Homotypic and heterotypic cell-cell interactions," Prog. Clin. Biol. Res. 294: 425-34.

Kliman H.J., Coutifaris C., Feinberg R.F., Strauss J.F. III, Haimowitz J.E. Implantation: In vitro human models utilizing human tissues. In: Blastocyst Implantation. K. Yoshinaga (ed), Serono Symposia, 1989.
Kliman H.J. and Feinberg R.F. Differentiation of the Trophoblast. In: The First Twelve Weeks. J. Hustin, E. Jauniaux, ER Barnea (eds), Springer-Verlag Publishers, 1992.

Feinberg R.F., Kliman H.J. and Wang C.-L. Tropho-uteronectin (TUN): A Fibronectin Marker of Trophoblast Attachment and Differentiation in vivo and in vitro. In: Local Systems in Reproduction. F. Naftolin and R. Magness (ed), Serono Symposia, 1992.

Feinberg R.F. and Kliman H.J. Human Trophoblasts and Tropho-uteronectin (TUN): A Model for Studying Early Implantation Events. Assisted Reproduction Rev 3: 19-25, 1993.

Dunn P.A. and Feinberg R.F. Oncofetal Fibronectin: New Insight into the Physiology of Implantation and Labor. Journal of Obstetric, Gynecologic, and Neonatal Nursing, 1996.

Timbers K.A. and Feinberg R.F., Recurrent pregnancy loss: A review. Nurse Practitioner Forum 7: 64-75, 1996.

Feinberg R.F. and Kliman H.J. MAG (Mouse Ascites Golgi) Mucin in the Endometrium: A Potential Marker of Endometrial Receptivity to Implantation". In. The Endometrium and Endometriosis. M. Diamond and K. Osteen (eds), Blackwell Science Publishers, 1997.

Feinberg R.F. and Sciscione A. (1998) Early Recurrent Pregnancy Loss: A Board Review Manual, Hospital Physician.

As a Board-certified Reproductive Endocrinologist, Dr. Feinberg is the Medical Director for the IVF Program at Reproductive Associates. A native Philadelphian, Dr. Feinberg graduated with both M.D. and Ph.D. degrees from the University of Pennsylvania School of Medicine in 1983. His Ph.D. work formed the basis for his career in reproductive endocrinology and infertility, focusing on how steroid hormones function within the body. Dr. Feinberg extended his clinical work in Women's Health by completing an internship and residency in Obstetrics and Gynecology at Yale-New Haven Hospital and Yale University in 1987. He then returned to the University of Pennsylvania as an Assistant Professor on the Standing Faculty in the Department of Obstetrics and Gynecology. In addition to his clinical practice, he directed a March of Dimes funded and National Institutes of Health funded research laboratory studying the molecules responsible of human embryo implantation. In 1993 Dr. Feinberg was awarded a sabbatical to pursue a clinical subspecialty Fellowship in Reproductive Endocrinology and Infertility at Penn. He remained on the Faculty at Penn through his Fellowship and until 1997, when he joined Dr. McGuirk at Reproductive Associates of Delaware. He also joined the clinical faculty at Yale University School of Medicine in 1997, where he is currently an Associate Professor (Adjunct) in the Department of Obstetrics and Gynecology and Division of Reproductive Endocrinology and Infertility. He is an attending physician with the Christiana Care Health System/Medical Center of Delaware. Dr. Feinberg has co-authored 35 publications, most as lead or senior author. He is an associate member of the Society for Gynecologic Investigation, a member of the American Society for Reproductive Medicine (ASRM), and a Fellow of the American College of Obstetricians/Gynecologists (ACOG). Dr. Feinberg is also Board Certified by the American Board of Obstetrics and Gynecology.