Research Interests and Goals:
Physiology and pathology of male and female reproduction. Stimulators, modulators and regulators of spermatogenesis and spermiogenesis. Stimulators, modulators, and regulators of folliculogenesis and ovulation. Mechanism of action of gonadotropins and growth factors on gene expression and steroidogenesis. Molecular mechanism of cell proliferation and cell death in hormone dependent tumors.

Previous and Current Research:
Characterized the chemical and biological nature of human menopausal gonadotropins and discovered their use in male and female infertility. With his collaborators he established a diagnostic, therapeutic oriented, classification system for male and female infertility. Proposed guidelines for the management of infertility and designed effective treatment protocols. Research focused on the understanding of mechanisms controlling the hypothalamic-pituitary gonadal and adrenal axis and in the understanding of the nature, development and pathogenesis of diseases leading to functional abnormalities in this axis. Current research involves: 1) subcellular and molecular nature of granulosa cell response to gonadotropins, growth factors and binding globulins. 2) Effects of gonadotropins on spermatogenesis and spermiogenesis.

Interests and Future projects:
The mode of action of gonadotropins, growth factors and their binding globulins in ovarian and testicular regulation and function. The application of results of such basic research to clinical diagnostic preventive and therapeutic strategies. Development of strategies in teaching and transfer of technology related to endocrinology and reproduction.

• M.D. Medical School, University Geneva, 1954
• Visiting Scientist, Weizmann Institute of Science (1957-1961)
• Director Institute of Endocrinology (1961- 1992);
• Chairman Research & Ethical Committee (1977-1981) Sheba Medical Center
• Since 1967 Consultant and Member of various committees, World Health Organization (WHO)
• Joined Bar-Ilan University in 1967 and Founded and Headed the Department of Life Sciences in 1969
• Full Professor since 1969
• Fellow Ad Eundum Royal College of Obstetrics and Gynecologists, U.K. (FRCOG) since 1981
• Counselor Extern. Relations & Head Dept. Internat. Relations (1971-1985);
• Acting Chief Scientist (1984-1986), Ministry of Health
• President - Israel Fertility Association (1979- 1983); Israel Endocrine Society (since 1991)
• Vice President Scientific Council, Israel Medical Association since 1990 Honorary Fellow of the American College of Obstetricians & Gynecology (FACOG hon.) 1991 & Honorary Member - Italian & French Society of Gynecology; The German Endocrine Society; The Austrian Society of Fertility and Sterility.
• Since 1989 Member of Executive Council Intern. Soc. of Gynecology. Endocrinology and Intern. Committee of Research in Reproduction;
• Founder and organizer of the International Symposiums on GnRH Analogues in Cancer and Human Reproduction; International Symposiums on the Aging Male;
• 492 publications, 350 in refereed journals, 112 Reports, Reviews & Chapters in Books and Author, Co-Author or Editor of 30 books.
• 50 students (5 Ph.D., 12 M.Sc. and 33 M.D.) have been supervised in his laboratory and 4 (1 Ph.D. and 3 M.Sc.) are currently enrolled.